| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 3,250,000 | 13,033,000 | 11.57% | ||
| 2 | BVF INC/IL | 2,650,563 | 10,629,000 | 9.43% | ||
| 3 | Ancora Advisors LLC | 2,308,561 | 9,257,000 | 8.21% | ||
| 4 | SCOPIA CAPITAL MANAGEMENT LP | 2,172,096 | 8,710,000 | 7.73% | ||
| 5 | Tiger Legatus Capital Management, LLC | 1,901,000 | 7,623,000 | 6.76% | ||
| 6 | Palo Alto Investors LP | 1,733,208 | 6,950,000 | 6.17% | ||
| 7 | BAKER BROS. ADVISORS LP | 1,535,863 | 6,159,000 | 5.47% | ||
| 8 | Connor, Clark & Lunn Investment Management Ltd. | 1,156,974 | 4,625,000 | 4.10% | ||
| 9 | Broadfin Capital, LLC | 1,145,527 | 4,594,000 | 4.08% | ||
| 10 | GOLDMAN SACHS GROUP INC | 1,033,041 | 4,142,000 | 3.68% | ||
| 11 | DEUTSCHE BANK AG\ | 959,208 | 3,845,000 | 3.41% | ||
| 12 | GREENWOOD INVESTMENTS, INC. | 851,068 | 3,413,000 | 3.03% | ||
| 13 | Gruss Capital Management LP | 695,000 | 2,787,000 | 2.47% | ||
| 14 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 688,235 | 2,760,000 | 2.45% | ||
| 15 | BlackRock Fund Advisors | 598,583 | 2,400,000 | 2.13% | ||
| 16 | CANADA PENSION PLAN INVESTMENT BOARD | 502,890 | 2,017,000 | 1.79% | ||
| 17 | GOLDMAN SACHS GROUP INC | 500,000 | 2,005,000 | 1.78% | Put | |
| 18 | KNOTT DAVID M | 445,926 | 1,788,163 | 1.59% | ||
| 19 | MORGAN STANLEY | 362,332 | 1,453,000 | 1.29% | ||
| 20 | NORGES BANK | 354,679 | 1,418,000 | 1.26% | ||
| 21 | Healthcare Value Capital, LLC | 350,000 | 1,404,000 | 1.25% | ||
| 22 | OXFORD ASSET MANAGEMENT LLP | 343,471 | 1,386,000 | 1.23% | ||
| 23 | D. E. Shaw & Co., Inc. | 292,838 | 1,175,000 | 1.04% | ||
| 24 | TWO SIGMA INVESTMENTS, LP | 241,539 | 969,000 | 0.86% | ||
| 25 | LEVIN CAPITAL STRATEGIES, L.P. | 226,678 | 909,000 | 0.81% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 218,687 | 877,000 | 0.78% | ||
| 27 | VERTEX ONE ASSET MANAGEMENT INC. | 160,334 | 641,000 | 0.57% | ||
| 28 | WOLVERINE ASSET MANAGEMENT LLC | 158,914 | 637,000 | 0.57% | ||
| 29 | Healthcare Value Capital, LLC | 150,000 | 602,000 | 0.53% | Call | |
| 30 | TWO SIGMA ADVISERS, LP | 130,400 | 523,000 | 0.46% | ||
| 31 | FRANKLIN RESOURCES INC | 119,942 | 478,000 | 0.42% | ||
| 32 | PRELUDE CAPITAL MANAGEMENT, LLC | 115,650 | 464,000 | 0.41% | ||
| 33 | Leonard Capital Management, Inc. | 110,074 | 441,000 | 0.39% | ||
| 34 | First Eagle Investment Management, LLC | 67,972 | 273,000 | 0.24% | ||
| 35 | K2 PRINCIPAL FUND, L.P. | 63,600 | 255,000 | 0.23% | ||
| 36 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 50,000 | 223,000 | 0.20% | ||
| 37 | Nine Chapters Capital Management LLC | 55,200 | 221,000 | 0.20% | ||
| 38 | PDT Partners, LLC | 50,738 | 203,000 | 0.18% | ||
| 39 | Invesco Ltd. | 46,031 | 185,000 | 0.16% | ||
| 40 | ProShare Advisors LLC | 33,901 | 136,000 | 0.12% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,072 | 97,000 | 0.09% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,200 | 97,000 | 0.09% | Call | |
| 43 | CITADEL ADVISORS LLC | 23,939 | 96,000 | 0.09% | ||
| 44 | Yakira Capital Management, Inc. | 22,804 | 91,000 | 0.08% | SH | |
| 45 | CREDIT SUISSE AG/ | 22,099 | 89,000 | 0.08% | ||
| 46 | Virtu KCG Holdings LLC | 20,590 | 83,000 | 0.07% | ||
| 47 | Cubist Systematic Strategies, LLC | 20,187 | 80,000 | 0.07% | ||
| 48 | Krensavage Asset Management, LLC | 17,000 | 68,000 | 0.06% | ||
| 49 | Airain ltd | 12,520 | 50,000 | 0.04% | ||
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 11,940 | 47,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
