| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 5,364,385 | 14,269,000 | 15.58% | ||
| 2 | Broadfin Capital, LLC | 4,445,527 | 11,825,000 | 12.91% | ||
| 3 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 3,000,000 | 7,980,000 | 8.71% | ||
| 4 | Healthcare Value Capital, LLC | 2,157,200 | 5,738,000 | 6.26% | ||
| 5 | Ancora Advisors LLC | 2,062,509 | 5,486,000 | 5.99% | ||
| 6 | Connor, Clark & Lunn Investment Management Ltd. | 1,797,083 | 4,722,000 | 5.15% | ||
| 7 | LEVIN CAPITAL STRATEGIES, L.P. | 1,671,591 | 4,446,000 | 4.85% | ||
| 8 | Tiger Legatus Capital Management, LLC | 1,650,000 | 4,389,000 | 4.79% | ||
| 9 | JW Asset Management, LLC | 1,592,993 | 4,237,000 | 4.63% | ||
| 10 | BANK OF MONTREAL /CAN/ | 1,560,530 | 4,151,000 | 4.53% | ||
| 11 | ISZO CAPITAL MANAGEMENT LP | 802,600 | 2,135,000 | 2.33% | ||
| 12 | GREENWOOD INVESTMENTS, INC. | 766,068 | 2,038,000 | 2.22% | ||
| 13 | Gruss Capital Management LP | 765,000 | 2,035,000 | 2.22% | ||
| 14 | SCOPIA CAPITAL MANAGEMENT LP | 634,087 | 1,687,000 | 1.84% | ||
| 15 | GOLDMAN SACHS GROUP INC | 561,878 | 1,495,000 | 1.63% | ||
| 16 | KNOTT DAVID M | 545,926 | 1,452,163 | 1.59% | ||
| 17 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 509,453 | 1,355,000 | 1.48% | ||
| 18 | ORBIMED ADVISORS LLC | 500,000 | 1,330,000 | 1.45% | ||
| 19 | D. E. Shaw & Co., Inc. | 426,068 | 1,133,000 | 1.24% | ||
| 20 | FRANKLIN STREET ADVISORS INC /NC | 369,200 | 982,000 | 1.07% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 362,264 | 964,000 | 1.05% | ||
| 22 | NORGES BANK | 354,679 | 932,000 | 1.02% | ||
| 23 | DEUTSCHE BANK AG\ | 304,212 | 808,000 | 0.88% | ||
| 24 | ACUTA CAPITAL PARTNERS, LLC | 301,160 | 801,000 | 0.87% | ||
| 25 | BRANDES INVESTMENT PARTNERS, LP | 224,071 | 596,000 | 0.65% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 217,575 | 579,000 | 0.63% | ||
| 27 | OXFORD ASSET MANAGEMENT LLP | 210,707 | 560,000 | 0.61% | ||
| 28 | PRELUDE CAPITAL MANAGEMENT, LLC | 185,000 | 492,000 | 0.54% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 140,000 | 372,000 | 0.41% | ||
| 30 | Anson Funds Management LP | 127,000 | 338,000 | 0.37% | ||
| 31 | Yakira Capital Management, Inc. | 105,486 | 281,000 | 0.31% | SH | |
| 32 | EcoR1 Capital, LLC | 100,000 | 266,000 | 0.29% | ||
| 33 | Jefferies Group LLC | 73,494 | 194,000 | 0.21% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 72,480 | 193,000 | 0.21% | ||
| 35 | TWO SIGMA ADVISERS, LP | 70,600 | 188,000 | 0.21% | ||
| 36 | BlackRock Institutional Trust Company, N.A. | 65,648 | 175,000 | 0.19% | ||
| 37 | MORGAN STANLEY | 46,529 | 124,000 | 0.14% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 43,207 | 115,000 | 0.13% | ||
| 39 | TFS CAPITAL LLC | 33,375 | 89,000 | 0.10% | ||
| 40 | Clear Harbor Asset Management, LLC | 30,000 | 80,000 | 0.09% | ||
| 41 | HOLLENCREST CAPITAL MANAGEMENT | 30,000 | 80,000 | 0.09% | ||
| 42 | Virtu KCG Holdings LLC | 25,588 | 68,000 | 0.07% | ||
| 43 | Hillsdale Investment Management Inc. | 23,500 | 63,000 | 0.07% | ||
| 44 | SIMPLEX TRADING, LLC | 22,786 | 60,000 | 0.07% | ||
| 45 | GEODE CAPITAL MANAGEMENT, LLC | 20,523 | 54,000 | 0.06% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,734 | 42,000 | 0.05% | ||
| 47 | Paloma Partners Management Co | 13,416 | 36,000 | 0.04% | ||
| 48 | A.R.T. Advisors, LLC | 12,789 | 34,000 | 0.04% | ||
| 49 | 1492 Capital Management LLC | 10,000 | 27,000 | 0.03% | ||
| 50 | CITADEL ADVISORS LLC | 9,473 | 25,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
