| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | AXIAL CAPITAL MANAGEMENT, LLC | 8,865,036 | 49,290,000 | 25.31% | ||
| 2 | Visium Asset Management, LP | 4,435,000 | 24,659,000 | 12.66% | ||
| 3 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 3,250,000 | 18,070,000 | 9.28% | ||
| 4 | BVF INC/IL | 2,370,263 | 13,179,000 | 6.77% | ||
| 5 | SCOPIA CAPITAL MANAGEMENT LP | 2,106,596 | 11,713,000 | 6.01% | ||
| 6 | Palo Alto Investors LP | 2,041,043 | 11,348,000 | 5.83% | ||
| 7 | Tiger Legatus Capital Management, LLC | 1,750,000 | 9,730,000 | 5.00% | ||
| 8 | BAKER BROS. ADVISORS LP | 1,535,863 | 8,539,000 | 4.38% | ||
| 9 | GREENWOOD INVESTMENTS, INC. | 1,235,144 | 6,867,000 | 3.53% | ||
| 10 | Connor, Clark & Lunn Investment Management Ltd. | 889,754 | 5,472,000 | 2.81% | ||
| 11 | Broadfin Capital, LLC | 784,893 | 4,364,000 | 2.24% | ||
| 12 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 655,482 | 3,644,000 | 1.87% | ||
| 13 | Healthcare Value Capital, LLC | 626,639 | 3,484,000 | 1.79% | ||
| 14 | CANADA PENSION PLAN INVESTMENT BOARD | 484,423 | 2,693,000 | 1.38% | ||
| 15 | KNOTT DAVID M | 445,926 | 2,479,349 | 1.27% | ||
| 16 | NORGES BANK | 354,679 | 1,976,000 | 1.01% | ||
| 17 | LEVIN CAPITAL STRATEGIES, L.P. | 348,002 | 1,935,000 | 0.99% | ||
| 18 | D. E. Shaw & Co., Inc. | 347,026 | 1,930,000 | 0.99% | ||
| 19 | Newtyn Management, LLC | 325,000 | 1,807,000 | 0.93% | ||
| 20 | VERTEX ONE ASSET MANAGEMENT INC. | 320,334 | 1,785,000 | 0.92% | ||
| 21 | ORBIMED ADVISORS LLC | 300,000 | 1,668,000 | 0.86% | ||
| 22 | GOLDMAN SACHS GROUP INC | 250,243 | 1,391,000 | 0.71% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 1,112,000 | 0.57% | ||
| 24 | Healthcare Value Capital, LLC | 200,000 | 1,112,000 | 0.57% | Call | |
| 25 | FRANKLIN RESOURCES INC | 119,942 | 667,000 | 0.34% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 95,164 | 529,000 | 0.27% | ||
| 27 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,400 | 475,000 | 0.24% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 67,600 | 417,000 | 0.21% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,930 | 361,000 | 0.19% | ||
| 30 | PDT Partners, LLC | 51,400 | 286,000 | 0.15% | ||
| 31 | Invesco Ltd. | 41,746 | 232,000 | 0.12% | ||
| 32 | PRELUDE CAPITAL MANAGEMENT, LLC | 40,000 | 222,000 | 0.11% | ||
| 33 | Yakira Capital Management, Inc. | 34,204 | 190,000 | 0.10% | ||
| 34 | DEUTSCHE BANK AG\ | 32,050 | 177,000 | 0.09% | ||
| 35 | BlackRock Institutional Trust Company, N.A. | 29,422 | 164,000 | 0.08% | ||
| 36 | TFS CAPITAL LLC | 27,777 | 154,000 | 0.08% | ||
| 37 | MORGAN STANLEY | 23,811 | 132,000 | 0.07% | ||
| 38 | FRED ALGER MANAGEMENT, LLC | 16,420 | 91,000 | 0.05% | ||
| 39 | STATE STREET CORP | 13,991 | 78,000 | 0.04% | ||
| 40 | GSA CAPITAL PARTNERS LLP | 11,467 | 64,000 | 0.03% | ||
| 41 | CITADEL ADVISORS LLC | 11,199 | 62,000 | 0.03% | ||
| 42 | A.R.T. Advisors, LLC | 10,244 | 56,000 | 0.03% | ||
| 43 | BANK OF MONTREAL /CAN/ | 3,950 | 22,000 | 0.01% | ||
| 44 | D.A. DAVIDSON & CO. | 2,900 | 16,000 | 0.01% | ||
| 45 | UBS AG | 2,601 | 15,000 | 0.01% | ||
| 46 | TORONTO DOMINION BANK | 2,018 | 12,000 | 0.01% | ||
| 47 | Bartlett & Co. LLC | 2,000 | 11,000 | 0.01% | ||
| 48 | ROYAL BANK OF CANADA | 2,075 | 11,000 | 0.01% | ||
| 49 | FIRST MANHATTAN CO. LLC. | 2,000 | 11,000 | 0.01% | ||
| 50 | ACADIAN ASSET MANAGEMENT LLC | 1,647 | 9,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
