| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,445,527 | 18,360,000 | 12.44% | ||
| 2 | BVF INC/IL | 3,737,446 | 15,436,000 | 10.46% | ||
| 3 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 3,250,000 | 13,423,000 | 9.09% | ||
| 4 | SCOPIA CAPITAL MANAGEMENT LP | 2,907,096 | 12,006,000 | 8.13% | ||
| 5 | Healthcare Value Capital, LLC | 2,107,200 | 8,703,000 | 5.90% | ||
| 6 | Ancora Advisors LLC | 1,911,301 | 7,894,000 | 5.35% | ||
| 7 | Connor, Clark & Lunn Investment Management Ltd. | 1,690,458 | 6,973,000 | 4.72% | ||
| 8 | Tiger Legatus Capital Management, LLC | 1,600,000 | 6,608,000 | 4.48% | ||
| 9 | JW Asset Management, LLC | 1,592,993 | 6,579,000 | 4.46% | ||
| 10 | LEVIN CAPITAL STRATEGIES, L.P. | 1,243,077 | 5,134,000 | 3.48% | ||
| 11 | GREENWOOD INVESTMENTS, INC. | 851,068 | 3,515,000 | 2.38% | ||
| 12 | Gruss Capital Management LP | 765,000 | 3,159,000 | 2.14% | ||
| 13 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 719,681 | 2,972,000 | 2.01% | ||
| 14 | GOLDMAN SACHS GROUP INC | 705,866 | 2,915,000 | 1.98% | ||
| 15 | BlackRock Fund Advisors | 677,536 | 2,798,000 | 1.90% | ||
| 16 | ARMISTICE CAPITAL, LLC | 660,000 | 2,726,000 | 1.85% | ||
| 17 | DEUTSCHE BANK AG\ | 643,433 | 2,656,000 | 1.80% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 564,415 | 2,331,000 | 1.58% | ||
| 19 | KNOTT DAVID M | 545,926 | 2,254,674 | 1.53% | ||
| 20 | Park West Asset Management LLC | 500,000 | 2,065,000 | 1.40% | ||
| 21 | ORBIMED ADVISORS LLC | 500,000 | 2,065,000 | 1.40% | ||
| 22 | TWO SIGMA INVESTMENTS, LP | 462,874 | 1,912,000 | 1.30% | ||
| 23 | MORGAN STANLEY | 420,885 | 1,738,000 | 1.18% | ||
| 24 | EcoR1 Capital, LLC | 400,000 | 1,652,000 | 1.12% | ||
| 25 | FRANKLIN STREET ADVISORS INC /NC | 373,500 | 1,543,000 | 1.05% | ||
| 26 | NORGES BANK | 354,679 | 1,463,000 | 0.99% | ||
| 27 | D. E. Shaw & Co., Inc. | 333,693 | 1,379,000 | 0.93% | ||
| 28 | TWO SIGMA ADVISERS, LP | 329,900 | 1,362,000 | 0.92% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 204,949 | 846,000 | 0.57% | ||
| 30 | BRANDES INVESTMENT PARTNERS, LP | 153,280 | 633,000 | 0.43% | ||
| 31 | VERTEX ONE ASSET MANAGEMENT INC. | 130,149 | 537,000 | 0.36% | ||
| 32 | GROUP ONE TRADING LLC | 124,758 | 515,000 | 0.35% | ||
| 33 | PRELUDE CAPITAL MANAGEMENT, LLC | 120,300 | 497,000 | 0.34% | ||
| 34 | Yakira Capital Management, Inc. | 109,340 | 452,000 | 0.31% | SH | |
| 35 | TFS CAPITAL LLC | 65,121 | 269,000 | 0.18% | ||
| 36 | CREDIT SUISSE AG/ | 50,538 | 209,000 | 0.14% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,000 | 194,000 | 0.13% | Put | |
| 38 | ProShare Advisors LLC | 40,953 | 169,000 | 0.11% | ||
| 39 | BlackRock Institutional Trust Company, N.A. | 40,451 | 167,000 | 0.11% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,097 | 145,000 | 0.10% | ||
| 41 | SIMPLEX TRADING, LLC | 34,883 | 144,000 | 0.10% | ||
| 42 | CITADEL ADVISORS LLC | 32,515 | 134,000 | 0.09% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 31,131 | 129,000 | 0.09% | ||
| 44 | HOLLENCREST CAPITAL MANAGEMENT | 30,000 | 124,000 | 0.08% | ||
| 45 | DekaBank Deutsche Girozentrale | 25,000 | 103,000 | 0.07% | ||
| 46 | SMITH ASSET MANAGEMENT GROUP LP | 22,605 | 93,000 | 0.06% | ||
| 47 | Cubist Systematic Strategies, LLC | 22,255 | 92,000 | 0.06% | ||
| 48 | GEODE CAPITAL MANAGEMENT, LLC | 19,899 | 82,000 | 0.06% | ||
| 49 | Airain ltd | 19,479 | 80,000 | 0.05% | ||
| 50 | Visium Asset Management, LP | 17,900 | 74,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
