| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 5,701,609 | 11,346,000 | 17.69% | ||
| 2 | Broadfin Capital, LLC | 4,445,527 | 8,847,000 | 13.80% | ||
| 3 | Ancora Advisors LLC | 3,347,119 | 6,661,000 | 10.39% | ||
| 4 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 3,000,000 | 5,970,000 | 9.31% | ||
| 5 | Healthcare Value Capital, LLC | 2,157,200 | 4,293,000 | 6.69% | ||
| 6 | Tiger Legatus Capital Management, LLC | 1,650,469 | 3,284,000 | 5.12% | ||
| 7 | JW Asset Management, LLC | 1,592,993 | 3,170,000 | 4.94% | ||
| 8 | Connor, Clark & Lunn Investment Management Ltd. | 1,386,208 | 2,701,000 | 4.21% | ||
| 9 | LEVIN CAPITAL STRATEGIES, L.P. | 1,226,728 | 2,441,000 | 3.81% | ||
| 10 | ISZO CAPITAL MANAGEMENT LP | 792,502 | 1,577,000 | 2.46% | ||
| 11 | Gruss Capital Management LP | 765,000 | 1,522,000 | 2.37% | ||
| 12 | KNOTT DAVID M | 545,926 | 1,086,393 | 1.69% | ||
| 13 | GOLDMAN SACHS GROUP INC | 525,282 | 1,045,000 | 1.63% | ||
| 14 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 509,053 | 1,013,000 | 1.58% | ||
| 15 | ORBIMED ADVISORS LLC | 500,000 | 995,000 | 1.55% | ||
| 16 | D. E. Shaw & Co., Inc. | 448,292 | 892,000 | 1.39% | ||
| 17 | GREENWOOD INVESTMENTS, INC. | 428,844 | 853,000 | 1.33% | ||
| 18 | FRANKLIN STREET ADVISORS INC /NC | 360,000 | 716,000 | 1.12% | ||
| 19 | NORGES BANK | 354,679 | 691,000 | 1.08% | ||
| 20 | DEUTSCHE BANK AG\ | 280,704 | 558,000 | 0.87% | ||
| 21 | PRELUDE CAPITAL MANAGEMENT, LLC | 225,000 | 448,000 | 0.70% | ||
| 22 | BRANDES INVESTMENT PARTNERS, LP | 224,071 | 446,000 | 0.70% | ||
| 23 | Yakira Capital Management, Inc. | 211,114 | 420,000 | 0.65% | SH | |
| 24 | Jefferies Group LLC | 215,951 | 419,000 | 0.65% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 208,490 | 415,000 | 0.65% | ||
| 26 | OXFORD ASSET MANAGEMENT LLP | 175,637 | 350,000 | 0.55% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 140,000 | 279,000 | 0.44% | ||
| 28 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 102,900 | 205,000 | 0.32% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 101,623 | 202,000 | 0.32% | ||
| 30 | Healthcare Value Capital, LLC | 100,000 | 147,000 | 0.23% | Call | |
| 31 | TWO SIGMA ADVISERS, LP | 70,600 | 140,000 | 0.22% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,500 | 116,000 | 0.18% | Put | |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,007 | 113,000 | 0.18% | ||
| 34 | CITADEL ADVISORS LLC | 42,816 | 85,000 | 0.13% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 40,207 | 80,000 | 0.12% | ||
| 36 | MORGAN STANLEY | 37,148 | 74,000 | 0.12% | ||
| 37 | HOLLENCREST CAPITAL MANAGEMENT | 30,000 | 60,000 | 0.09% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 29,084 | 58,000 | 0.09% | ||
| 39 | BlackRock Institutional Trust Company, N.A. | 26,568 | 53,000 | 0.08% | ||
| 40 | TFS CAPITAL LLC | 26,444 | 53,000 | 0.08% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 26,767 | 53,000 | 0.08% | ||
| 42 | Clear Harbor Asset Management, LLC | 26,000 | 52,000 | 0.08% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 25,000 | 50,000 | 0.08% | ||
| 44 | SIMPLEX TRADING, LLC | 21,374 | 42,000 | 0.07% | ||
| 45 | A.R.T. Advisors, LLC | 11,089 | 22,000 | 0.03% | ||
| 46 | 1492 Capital Management LLC | 10,000 | 20,000 | 0.03% | ||
| 47 | Walleye Trading LLC | 9,400 | 19,000 | 0.03% | ||
| 48 | BANK OF MONTREAL /CAN/ | 5,530 | 11,000 | 0.02% | ||
| 49 | D.A. DAVIDSON & CO. | 2,900 | 5,000 | 0.01% | ||
| 50 | UBS Group AG | 1,796 | 4,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
