| 1 |
BVF INC/IL |
2,607,091 |
17,702,000 |
27.39% |
|
|
| 2 |
GILDER GAGNON HOWE & CO LLC |
2,269,974 |
15,413,000 |
23.85% |
|
|
| 3 |
PERCEPTIVE ADVISORS LLC |
860,000 |
5,839,000 |
9.03% |
|
|
| 4 |
Visium Asset Management, LP |
600,000 |
4,074,000 |
6.30% |
|
|
| 5 |
VANGUARD GROUP INC |
504,593 |
3,426,000 |
5.30% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
400,000 |
2,716,000 |
4.20% |
|
|
| 7 |
BlackRock Fund Advisors |
380,201 |
2,582,000 |
3.99% |
|
|
| 8 |
Biondo Investment Advisors, LLC |
270,725 |
1,838,000 |
2.84% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
238,949 |
1,622,000 |
2.51% |
|
|
| 10 |
SMITH ASSET MANAGEMENT GROUP LP |
179,010 |
1,215,000 |
1.88% |
|
|
| 11 |
SABBY MANAGEMENT, LLC |
131,000 |
889,000 |
1.38% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
109,165 |
741,000 |
1.15% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
108,980 |
740,000 |
1.14% |
|
|
| 14 |
TFS CAPITAL LLC |
89,174 |
605,000 |
0.94% |
|
|
| 15 |
BlackRock Group LTD |
88,909 |
604,000 |
0.93% |
|
|
| 16 |
BLACKROCK ADVISORS LLC |
78,815 |
535,000 |
0.83% |
|
|
| 17 |
Bank of New York Mellon Corp |
65,413 |
444,000 |
0.69% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
58,805 |
399,000 |
0.62% |
|
|
| 19 |
NORTHERN TRUST CORP |
43,467 |
295,000 |
0.46% |
|
|
| 20 |
BlackRock Investment Management, LLC |
43,038 |
292,000 |
0.45% |
|
|
| 21 |
STATE STREET CORP |
41,619 |
283,000 |
0.44% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
39,100 |
265,000 |
0.41% |
|
|
| 23 |
JANE STREET GROUP, LLC |
36,694 |
249,000 |
0.39% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
33,463 |
227,000 |
0.35% |
|
|
| 25 |
DAFNA Capital Management LLC |
30,000 |
204,000 |
0.32% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
28,200 |
191,000 |
0.30% |
|
|
| 27 |
DELTEC ASSET MANAGEMENT LLC |
26,600 |
181,000 |
0.28% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
23,793 |
162,000 |
0.25% |
|
|
| 29 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
22,700 |
155,000 |
0.24% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
20,996 |
143,000 |
0.22% |
|
|
| 31 |
MORGAN STANLEY |
14,057 |
96,000 |
0.15% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
12,781 |
87,000 |
0.13% |
|
|
| 33 |
RHUMBLINE ADVISERS |
12,360 |
84,000 |
0.13% |
|
|
| 34 |
Nationwide Fund Advisors |
11,420 |
78,000 |
0.12% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,106 |
68,620 |
0.11% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
6,500 |
44,000 |
0.07% |
|
|
| 37 |
STRS OHIO |
5,300 |
36,000 |
0.06% |
|
|
| 38 |
ALLIANCEBERNSTEIN L.P. |
3,400 |
23,000 |
0.04% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
3,146 |
20,000 |
0.03% |
|
|
| 40 |
BANK OF MONTREAL /CAN/ |
3,000 |
20,000 |
0.03% |
|
|
| 41 |
BlackRock Japan Co. Ltd |
2,210 |
15,000 |
0.02% |
|
|
| 42 |
VIRTUS CAPITAL ADVISERS, LLC |
1,318 |
9,000 |
0.01% |
|
|
| 43 |
UBS AG |
1,121 |
8,000 |
0.01% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
1,099 |
7,000 |
0.01% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
500 |
3,000 |
0.00% |
|
|
| 46 |
OPTIMUM INVESTMENT ADVISORS |
325 |
2,000 |
0.00% |
|
|
| 47 |
BARCLAYS PLC |
339 |
2,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
130 |
1,000 |
0.00% |
|
|
| 49 |
MYCIO WEALTH PARTNERS, LLC |
155 |
1,000 |
0.00% |
|
|
