| 1 |
Foresite Capital Management I, LLC |
2,079,569 |
14,370,000 |
21.49% |
|
|
| 2 |
Aisling Capital LLC |
1,650,156 |
11,400,000 |
17.05% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,490,769 |
10,301,000 |
15.41% |
|
|
| 4 |
GREAT POINT PARTNERS LLC |
1,053,895 |
7,282,000 |
10.89% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
747,954 |
5,168,000 |
7.73% |
|
|
| 6 |
FMR LLC |
398,679 |
2,755,000 |
4.12% |
|
|
| 7 |
Gruss Capital Management LP |
357,492 |
2,470,000 |
3.69% |
|
|
| 8 |
WEXFORD CAPITAL LP |
329,460 |
2,277,000 |
3.41% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
277,568 |
1,918,000 |
2.87% |
|
|
| 10 |
VANGUARD GROUP INC |
255,353 |
1,764,000 |
2.64% |
|
|
| 11 |
Artal Group S.A. |
250,000 |
1,728,000 |
2.58% |
|
|
| 12 |
EVENTIDE ASSET MANAGEMENT, LLC |
151,100 |
1,044,000 |
1.56% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
99,732 |
689,000 |
1.03% |
|
|
| 14 |
BAILARD, INC. |
93,000 |
643,000 |
0.96% |
|
|
| 15 |
MACQUARIE GROUP LTD |
76,500 |
529,000 |
0.79% |
|
|
| 16 |
BLACKROCK ADVISORS LLC |
54,414 |
376,000 |
0.56% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
45,100 |
312,000 |
0.47% |
|
|
| 18 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
40,000 |
276,000 |
0.41% |
|
|
| 19 |
Numeric Investors LLC |
35,131 |
243,000 |
0.36% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
35,078 |
242,000 |
0.36% |
|
|
| 21 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
34,600 |
239,000 |
0.36% |
|
|
| 22 |
BlackRock Fund Advisors |
27,049 |
187,000 |
0.28% |
|
|
| 23 |
Bank of New York Mellon Corp |
23,955 |
166,000 |
0.25% |
|
|
| 24 |
TWO SIGMA INVESTMENTS, LP |
21,673 |
150,000 |
0.22% |
|
|
| 25 |
NORTHERN TRUST CORP |
19,602 |
135,000 |
0.20% |
|
|
| 26 |
MORGAN STANLEY |
17,939 |
124,000 |
0.19% |
|
|
| 27 |
BlackRock Japan Co. Ltd |
4,376 |
30,000 |
0.04% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
2,518 |
18,000 |
0.03% |
|
|
| 29 |
BlackRock Investment Management, LLC |
1,938 |
13,000 |
0.02% |
|
|
| 30 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
289 |
2,000 |
0.00% |
|
|
| 31 |
CITIGROUP INC |
297 |
2,000 |
0.00% |
|
|
| 32 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
1,000 |
0.00% |
|
|
| 33 |
Ground Swell Capital, LLC |
167 |
1,000 |
0.00% |
|
|
| 34 |
TANG CAPITAL MANAGEMENT LLC |
46 |
0 |
0.00% |
|
|
| 35 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
50 |
0 |
0.00% |
|
|
