| 1 |
Foresite Capital Management I, LLC |
2,079,569 |
32,025,000 |
21.28% |
|
|
| 2 |
Aisling Capital LLC |
1,650,156 |
25,410,000 |
16.88% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,490,769 |
22,958,000 |
15.26% |
|
|
| 4 |
BAKER BROS. ADVISORS LP |
1,093,332 |
16,837,000 |
11.19% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
600,000 |
9,240,000 |
6.14% |
|
|
| 6 |
Gruss Capital Management LP |
443,318 |
6,827,000 |
4.54% |
|
|
| 7 |
VANGUARD GROUP INC |
282,451 |
4,350,000 |
2.89% |
|
|
| 8 |
UBS AG |
184,991 |
2,849,000 |
1.89% |
|
|
| 9 |
GLG Partners LP |
180,000 |
2,772,000 |
1.84% |
|
|
| 10 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
172,560 |
2,657,000 |
1.77% |
|
|
| 11 |
AQR CAPITAL MANAGEMENT LLC |
160,924 |
2,478,000 |
1.65% |
|
|
| 12 |
JPMORGAN CHASE & CO |
158,053 |
2,434,000 |
1.62% |
|
|
| 13 |
SECTORAL ASSET MANAGEMENT INC |
146,111 |
2,250,000 |
1.50% |
|
|
| 14 |
Loeb Offshore Management LP |
139,510 |
2,148,000 |
1.43% |
|
|
| 15 |
GABELLI FUNDS LLC |
100,000 |
1,540,000 |
1.02% |
|
|
| 16 |
Polar Asset Management Partners Inc. |
100,000 |
1,540,000 |
1.02% |
|
|
| 17 |
BAILARD, INC. |
93,000 |
1,432,000 |
0.95% |
|
|
| 18 |
MORGAN STANLEY |
88,336 |
1,360,000 |
0.90% |
|
|
| 19 |
TOWERVIEW LLC |
83,762 |
1,290,000 |
0.86% |
|
|
| 20 |
MACQUARIE GROUP LTD |
76,500 |
1,178,000 |
0.78% |
|
|
| 21 |
GAMCO INVESTORS, INC. ET AL |
49,500 |
762,000 |
0.51% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
45,200 |
696,000 |
0.46% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
45,100 |
695,000 |
0.46% |
|
|
| 24 |
JANE STREET GROUP, LLC |
44,299 |
682,000 |
0.45% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
34,600 |
533,000 |
0.35% |
|
|
| 26 |
OppenheimerFunds, Inc. |
33,915 |
522,000 |
0.35% |
|
|
| 27 |
BlackRock Fund Advisors |
25,213 |
388,000 |
0.26% |
|
|
| 28 |
Lombard Odier Asset Management (USA) Corp |
25,000 |
385,000 |
0.26% |
|
|
| 29 |
CSS LLC/IL |
24,622 |
379,000 |
0.25% |
|
|
| 30 |
Bank of New York Mellon Corp |
23,955 |
369,000 |
0.25% |
|
|
| 31 |
Jefferies Group LLC |
23,000 |
354,000 |
0.24% |
|
|
| 32 |
OMERS ADMINISTRATION Corp |
21,500 |
331,000 |
0.22% |
|
|
| 33 |
NORTHERN TRUST CORP |
19,525 |
301,000 |
0.20% |
|
|
| 34 |
NATIXIS |
15,663 |
241,000 |
0.16% |
|
|
| 35 |
PRELUDE CAPITAL MANAGEMENT, LLC |
5,000 |
77,000 |
0.05% |
|
|
| 36 |
AMERIPRISE FINANCIAL INC |
3,196 |
49,000 |
0.03% |
|
|
| 37 |
FIRST NEW YORK SECURITIES LLC /NY |
3,000 |
46,200 |
0.03% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
2,150 |
33,000 |
0.02% |
|
|
| 39 |
BlackRock Investment Management, LLC |
2,011 |
31,000 |
0.02% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
955 |
15,000 |
0.01% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
516 |
8,000 |
0.01% |
|
|
| 42 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
426 |
7,000 |
0.00% |
|
|
| 43 |
CITIGROUP INC |
367 |
6,000 |
0.00% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
3,000 |
0.00% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
50 |
1,000 |
0.00% |
|
|
| 46 |
TANG CAPITAL MANAGEMENT LLC |
46 |
0 |
0.00% |
|
|
