| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Foresite Capital Management I, LLC | 2,079,569 | 18,966,000 | 24.13% | ||
| 2 | ORBIMED ADVISORS LLC | 1,490,769 | 13,596,000 | 17.30% | ||
| 3 | FMR LLC | 918,684 | 8,378,000 | 10.66% | ||
| 4 | BAKER BROS. ADVISORS LP | 747,954 | 6,821,000 | 8.68% | ||
| 5 | GREAT POINT PARTNERS LLC | 719,261 | 6,560,000 | 8.35% | ||
| 6 | WEXFORD CAPITAL LP | 553,843 | 5,051,000 | 6.43% | ||
| 7 | Redmile Group, LLC | 367,602 | 3,353,000 | 4.27% | ||
| 8 | Artal Group S.A. | 250,000 | 2,280,000 | 2.90% | ||
| 9 | VANGUARD GROUP INC | 212,698 | 1,940,000 | 2.47% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 148,468 | 1,354,000 | 1.72% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 131,100 | 1,196,000 | 1.52% | ||
| 12 | MORGAN STANLEY | 124,987 | 1,140,000 | 1.45% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 93,069 | 849,000 | 1.08% | ||
| 14 | MACQUARIE GROUP LTD | 76,500 | 698,000 | 0.89% | ||
| 15 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 71,000 | 648,000 | 0.82% | ||
| 16 | Numeric Investors LLC | 58,484 | 533,000 | 0.68% | ||
| 17 | DRIEHAUS CAPITAL MANAGEMENT LLC | 57,708 | 526,000 | 0.67% | ||
| 18 | BLACKROCK ADVISORS LLC | 49,804 | 454,000 | 0.58% | ||
| 19 | ING GROEP NV | 50,000 | 439,000 | 0.56% | ||
| 20 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 45,100 | 411,000 | 0.52% | ||
| 21 | FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 38,054 | 347,000 | 0.44% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 35,139 | 320,000 | 0.41% | ||
| 23 | BAILARD, INC. | 35,000 | 319,000 | 0.41% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 27,829 | 254,000 | 0.32% | ||
| 25 | UBS AG | 27,776 | 253,000 | 0.32% | ||
| 26 | BlackRock Fund Advisors | 26,273 | 240,000 | 0.31% | ||
| 27 | SOROS FUND MANAGEMENT LLC | 25,300 | 231,000 | 0.29% | ||
| 28 | Bank of New York Mellon Corp | 23,830 | 217,000 | 0.28% | ||
| 29 | NORTHERN TRUST CORP | 19,727 | 180,000 | 0.23% | ||
| 30 | CREDIT SUISSE AG/ | 19,469 | 178,000 | 0.23% | ||
| 31 | Spark Investment Management LLC | 19,800 | 177,000 | 0.23% | ||
| 32 | TWO SIGMA INVESTMENTS, LP | 17,100 | 156,000 | 0.20% | ||
| 33 | NOMURA HOLDINGS INC | 14,204 | 132,000 | 0.17% | ||
| 34 | WELLS FARGO & COMPANY/MN | 12,901 | 118,000 | 0.15% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,344 | 103,000 | 0.13% | ||
| 36 | NATIXIS | 10,000 | 91,000 | 0.12% | ||
| 37 | PRELUDE CAPITAL MANAGEMENT, LLC | 3,700 | 34,000 | 0.04% | ||
| 38 | BlackRock Japan Co. Ltd | 1,771 | 16,000 | 0.02% | ||
| 39 | BARCLAYS PLC | 1,300 | 12,000 | 0.02% | ||
| 40 | CITIGROUP INC | 559 | 5,000 | 0.01% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 426 | 4,000 | 0.01% | ||
| 42 | MAGEE THOMSON INVESTMENT PARTNERS LLC | 291 | 3,000 | 0.00% | ||
| 43 | Tower Research Capital LLC (TRC) | 224 | 2,000 | 0.00% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 178 | 2,000 | 0.00% | ||
| 45 | TANG CAPITAL MANAGEMENT LLC | 46 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
