| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Senvest Management, LLC | 1,596,367 | 2,458,000 | 29.94% | ||
| 2 | BVF INC/IL | 1,501,000 | 2,312,000 | 28.16% | ||
| 3 | ORBIMED ADVISORS LLC | 1,135,000 | 1,748,000 | 21.29% | ||
| 4 | Opaleye Management Inc. | 490,000 | 754,600 | 9.19% | ||
| 5 | SPHERA FUNDS MANAGEMENT LTD. | 193,284 | 298,000 | 3.63% | ||
| 6 | DEUTSCHE BANK AG\ | 191,850 | 295,000 | 3.59% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 128,100 | 197,000 | 2.40% | ||
| 8 | Benchmark Capital Advisors | 40,000 | 62,000 | 0.76% | ||
| 9 | NEXT Financial Group, Inc | 19,500 | 30,000 | 0.37% | ||
| 10 | Bank of New York Mellon Corp | 17,800 | 27,000 | 0.33% | ||
| 11 | MORGAN STANLEY | 10,275 | 16,000 | 0.19% | ||
| 12 | Tower Research Capital LLC (TRC) | 4,326 | 7,000 | 0.09% | ||
| 13 | ROYAL BANK OF CANADA | 2,000 | 3,000 | 0.04% | ||
| 14 | WELLS FARGO & COMPANY/MN | 1,000 | 2,000 | 0.02% | ||
| 15 | UBS AG | 624 | 1,000 | 0.01% | ||
| 16 | AMERIPRISE FINANCIAL INC | 291 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
