| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 5,006,490 | 547,159,000 | 12.34% | ||
| 2 | VANGUARD GROUP INC | 2,780,682 | 303,901,000 | 6.85% | ||
| 3 | Palo Alto Investors LP | 2,066,919 | 225,894,000 | 5.10% | ||
| 4 | BlackRock Fund Advisors | 1,565,070 | 171,047,000 | 3.86% | ||
| 5 | Essex Woodlands Management, Inc. | 1,450,000 | 158,471,000 | 3.57% | ||
| 6 | Jackson Square Partners, LLC | 1,238,653 | 135,372,000 | 3.05% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,160,974 | 126,883,000 | 2.86% | ||
| 8 | 1832 Asset Management L.P. | 1,122,900 | 121,857,000 | 2.75% | ||
| 9 | STATE STREET CORP | 1,082,842 | 118,348,000 | 2.67% | ||
| 10 | LORD, ABBETT & CO. LLC | 829,341 | 90,639,000 | 2.04% | ||
| 11 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 813,371 | 88,893,000 | 2.00% | ||
| 12 | MACQUARIE GROUP LTD | 809,706 | 88,493,000 | 2.00% | ||
| 13 | EAGLE ASSET MANAGEMENT INC | 758,138 | 82,856,000 | 1.87% | ||
| 14 | OAK RIDGE INVESTMENTS LLC | 657,789 | 71,890,000 | 1.62% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 621,723 | 67,948,000 | 1.53% | ||
| 16 | BAILLIE GIFFORD & CO | 598,353 | 65,394,000 | 1.47% | ||
| 17 | BROWN CAPITAL MANAGEMENT LLC | 593,959 | 64,914,000 | 1.46% | ||
| 18 | ROYAL BANK OF CANADA | 569,258 | 62,214,000 | 1.40% | ||
| 19 | GOLDMAN SACHS GROUP INC | 550,384 | 60,152,000 | 1.36% | ||
| 20 | NORGES BANK | 513,794 | 56,153,000 | 1.27% | ||
| 21 | Bank of New York Mellon Corp | 498,414 | 54,472,000 | 1.23% | ||
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 490,764 | 53,635,000 | 1.21% | ||
| 23 | JANUS HENDERSON GROUP PLC | 488,254 | 53,362,000 | 1.20% | ||
| 24 | NEXT CENTURY GROWTH INVESTORS LLC | 456,940 | 49,938,000 | 1.13% | ||
| 25 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 388,958 | 42,509,000 | 0.96% | ||
| 26 | BLAIR WILLIAM & CO/IL | 383,995 | 41,967,000 | 0.95% | ||
| 27 | NORTHERN TRUST CORP | 359,869 | 39,329,000 | 0.89% | ||
| 28 | Granahan Investment Management, LLC | 321,783 | 35,168,000 | 0.79% | ||
| 29 | CASTLEARK MANAGEMENT LLC | 303,577 | 33,178,000 | 0.75% | ||
| 30 | SECTORAL ASSET MANAGEMENT INC | 298,338 | 32,605,000 | 0.74% | ||
| 31 | Mitsubishi UFJ Trust & Banking Corp | 290,390 | 31,737,000 | 0.72% | ||
| 32 | ArrowMark Colorado Holdings LLC | 290,364 | 31,734,000 | 0.72% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 289,453 | 31,634,000 | 0.71% | ||
| 34 | MORGAN STANLEY | 285,531 | 31,206,000 | 0.70% | ||
| 35 | DEUTSCHE BANK AG\ | 276,347 | 30,199,000 | 0.68% | ||
| 36 | Nationwide Fund Advisors | 270,119 | 29,521,000 | 0.67% | ||
| 37 | SCOUT INVESTMENTS, INC. | 269,067 | 29,406,000 | 0.66% | ||
| 38 | Stephens Investment Management Group LLC | 262,478 | 28,686,000 | 0.65% | ||
| 39 | VOYA INVESTMENT MANAGEMENT LLC | 243,771 | 26,642,000 | 0.60% | ||
| 40 | ROCKEFELLER FINANCIAL SERVICES INC | 231,516 | 25,302,000 | 0.57% | ||
| 41 | FRED ALGER MANAGEMENT, LLC | 224,944 | 24,584,000 | 0.55% | ||
| 42 | Polar Capital LLP | 218,000 | 23,825,000 | 0.54% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 215,718 | 23,576,000 | 0.53% | ||
| 44 | AMERIPRISE FINANCIAL INC | 209,769 | 22,927,000 | 0.52% | ||
| 45 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,141 | 22,092,000 | 0.50% | ||
| 46 | OppenheimerFunds, Inc. | 199,261 | 21,777,000 | 0.49% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 192,315 | 21,018,000 | 0.47% | ||
| 48 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 190,106 | 20,777,000 | 0.47% | ||
| 49 | WELLS FARGO & COMPANY/MN | 186,559 | 20,389,000 | 0.46% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 183,073 | 20,008,000 | 0.45% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
