| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,516,387 | 42,140,000 | 21.12% | ||
| 2 | FMR LLC | 1,019,100 | 28,321,000 | 14.19% | ||
| 3 | HealthCor Management, L.P. | 900,000 | 25,011,000 | 12.53% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 597,363 | 16,601,000 | 8.32% | ||
| 5 | FRANKLIN RESOURCES INC | 510,400 | 14,184,000 | 7.11% | ||
| 6 | STIFEL FINANCIAL CORP | 444,904 | 12,364,000 | 6.20% | ||
| 7 | Cormorant Asset Management, LP | 400,000 | 11,116,000 | 5.57% | ||
| 8 | MORGAN STANLEY | 396,849 | 11,028,000 | 5.53% | ||
| 9 | BlackRock Fund Advisors | 192,817 | 5,358,000 | 2.69% | ||
| 10 | JENNISON ASSOCIATES LLC | 178,975 | 4,974,000 | 2.49% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 166,200 | 4,619,000 | 2.31% | ||
| 12 | VANGUARD GROUP INC | 147,874 | 4,110,000 | 2.06% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 82,509 | 2,293,000 | 1.15% | ||
| 14 | Visium Asset Management, LP | 74,768 | 2,078,000 | 1.04% | ||
| 15 | STATE STREET CORP | 72,982 | 2,027,000 | 1.02% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 72,500 | 2,015,000 | 1.01% | ||
| 17 | BLACKROCK ADVISORS LLC | 54,072 | 1,503,000 | 0.75% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 29,911 | 831,000 | 0.42% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 29,842 | 829,000 | 0.42% | ||
| 20 | Bank of New York Mellon Corp | 28,616 | 795,000 | 0.40% | ||
| 21 | BlackRock Group LTD | 24,000 | 667,000 | 0.33% | ||
| 22 | BlackRock Investment Management, LLC | 22,470 | 624,000 | 0.31% | ||
| 23 | ROYAL BANK OF CANADA | 20,950 | 582,000 | 0.29% | ||
| 24 | NORTHERN TRUST CORP | 20,761 | 577,000 | 0.29% | ||
| 25 | UBS AG | 16,731 | 465,000 | 0.23% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,613 | 462,000 | 0.23% | ||
| 27 | NORGES BANK | 15,000 | 417,000 | 0.21% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,777 | 411,000 | 0.21% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,300 | 397,000 | 0.20% | ||
| 30 | BANQUE PICTET & CIE SA | 13,942 | 387,000 | 0.19% | ||
| 31 | BlackRock Finance, Inc. | 11,698 | 326,000 | 0.16% | ||
| 32 | TEACHERS ADVISORS, LLC | 11,062 | 307,000 | 0.15% | ||
| 33 | JANE STREET GROUP, LLC | 11,000 | 306,000 | 0.15% | ||
| 34 | METROPOLITAN LIFE INSURANCE CO/NY | 9,285 | 258,000 | 0.13% | ||
| 35 | A.R.T. Advisors, LLC | 9,246 | 256,000 | 0.13% | ||
| 36 | Nationwide Fund Advisors | 5,971 | 166,000 | 0.08% | ||
| 37 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,175 | 144,000 | 0.07% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 5,124 | 142,396 | 0.07% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 3,600 | 100,000 | 0.05% | ||
| 40 | WELLS FARGO & COMPANY/MN | 3,457 | 96,000 | 0.05% | ||
| 41 | BARCLAYS PLC | 2,481 | 67,000 | 0.03% | ||
| 42 | FIFTH THIRD BANCORP | 1,826 | 51,000 | 0.03% | ||
| 43 | Tower Research Capital LLC (TRC) | 1,645 | 46,000 | 0.02% | ||
| 44 | BlackRock Japan Co. Ltd | 1,363 | 38,000 | 0.02% | ||
| 45 | VIRTUS CAPITAL ADVISERS, LLC | 668 | 19,000 | 0.01% | ||
| 46 | MCF Advisors LLC | 913 | 18,000 | 0.01% | ||
| 47 | Stifel Trust Company, N.A. | 100 | 3,000 | 0.00% | ||
| 48 | CITIGROUP INC | 106 | 3,000 | 0.00% | ||
| 49 | WFG Advisors, LP | 100 | 3,000 | 0.00% | ||
| 50 | DEUTSCHE BANK AG\ | 39 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
