| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,516,387 | 33,558,000 | 19.54% | ||
| 2 | FMR LLC | 999,400 | 22,117,000 | 12.88% | ||
| 3 | HealthCor Management, L.P. | 900,000 | 19,917,000 | 11.59% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 597,363 | 13,220,000 | 7.70% | ||
| 5 | STIFEL FINANCIAL CORP | 444,904 | 12,362,000 | 7.20% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 439,021 | 9,715,000 | 5.66% | ||
| 7 | FRANKLIN RESOURCES INC | 421,500 | 9,328,000 | 5.43% | ||
| 8 | Cormorant Asset Management, LP | 400,000 | 8,852,000 | 5.15% | ||
| 9 | MORGAN STANLEY | 302,912 | 6,704,000 | 3.90% | ||
| 10 | BlackRock Fund Advisors | 188,375 | 4,169,000 | 2.43% | ||
| 11 | JENNISON ASSOCIATES LLC | 179,232 | 3,966,000 | 2.31% | ||
| 12 | EVENTIDE ASSET MANAGEMENT, LLC | 166,200 | 3,678,000 | 2.14% | ||
| 13 | VANGUARD GROUP INC | 164,111 | 3,631,000 | 2.11% | ||
| 14 | FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 110,000 | 2,434,000 | 1.42% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 89,817 | 1,988,000 | 1.16% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,000 | 1,815,000 | 1.06% | Call | |
| 17 | NORTHERN TRUST CORP | 79,418 | 1,757,000 | 1.02% | ||
| 18 | STATE STREET CORP | 75,209 | 1,665,000 | 0.97% | ||
| 19 | Visium Asset Management, LP | 74,768 | 1,655,000 | 0.96% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 74,043 | 1,639,000 | 0.95% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 45,067 | 997,000 | 0.58% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 36,019 | 797,000 | 0.46% | ||
| 23 | UBS AG | 33,318 | 738,000 | 0.43% | ||
| 24 | AXIOM INVESTORS LLC /DE | 30,600 | 677,000 | 0.39% | ||
| 25 | Bank of New York Mellon Corp | 30,078 | 665,000 | 0.39% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 29,842 | 660,000 | 0.38% | ||
| 27 | BlackRock Investment Management, LLC | 22,900 | 507,000 | 0.30% | ||
| 28 | TFS CAPITAL LLC | 21,683 | 480,000 | 0.28% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,919 | 375,000 | 0.22% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,482 | 320,000 | 0.19% | ||
| 31 | BANQUE PICTET & CIE SA | 13,553 | 300,000 | 0.17% | ||
| 32 | TEACHERS ADVISORS, LLC | 11,062 | 245,000 | 0.14% | ||
| 33 | Nationwide Fund Advisors | 5,974 | 132,000 | 0.08% | ||
| 34 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,616 | 125,000 | 0.07% | ||
| 35 | AMERICAN INTERNATIONAL GROUP, INC. | 5,121 | 113,328 | 0.07% | ||
| 36 | FIFTH THIRD BANCORP | 4,326 | 96,000 | 0.06% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 3,600 | 80,000 | 0.05% | ||
| 38 | BLACKROCK ADVISORS LLC | 3,226 | 71,000 | 0.04% | ||
| 39 | STRS OHIO | 2,700 | 60,000 | 0.03% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 1,581 | 35,000 | 0.02% | ||
| 41 | WELLS FARGO & COMPANY/MN | 1,310 | 29,000 | 0.02% | ||
| 42 | ROYAL BANK OF CANADA | 1,250 | 28,000 | 0.02% | ||
| 43 | Stevens First Principles Investment Advisors | 850 | 19,000 | 0.01% | ||
| 44 | MCF Advisors LLC | 913 | 18,000 | 0.01% | ||
| 45 | BNP PARIBAS FINANCIAL MARKETS | 586 | 12,968 | 0.01% | ||
| 46 | BlackRock Finance, Inc. | 270 | 6,000 | 0.00% | ||
| 47 | CITIGROUP INC | 282 | 6,000 | 0.00% | ||
| 48 | GROUP ONE TRADING LLC | 236 | 5,000 | 0.00% | ||
| 49 | Stifel Trust Company, N.A. | 100 | 3,000 | 0.00% | ||
| 50 | BARCLAYS PLC | 81 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
