| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,516,387 | 17,651,000 | 18.61% | ||
| 2 | EAGLE ASSET MANAGEMENT INC | 1,222,631 | 14,231,000 | 15.01% | ||
| 3 | STIFEL FINANCIAL CORP | 444,804 | 11,641,000 | 12.28% | ||
| 4 | HealthCor Management, L.P. | 845,254 | 9,839,000 | 10.38% | ||
| 5 | FMR LLC | 724,200 | 8,430,000 | 8.89% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 597,363 | 6,953,000 | 7.33% | ||
| 7 | BlackRock Fund Advisors | 457,284 | 5,323,000 | 5.61% | ||
| 8 | VANGUARD GROUP INC | 231,325 | 2,693,000 | 2.84% | ||
| 9 | BALYASNY ASSET MANAGEMENT L.P. | 228,934 | 2,665,000 | 2.81% | ||
| 10 | MORGAN STANLEY | 123,535 | 1,438,000 | 1.52% | ||
| 11 | Cormorant Asset Management, LP | 118,000 | 1,374,000 | 1.45% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 115,008 | 1,339,000 | 1.41% | ||
| 13 | STATE STREET CORP | 98,616 | 1,144,000 | 1.21% | ||
| 14 | FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 94,000 | 1,094,000 | 1.15% | ||
| 15 | FRANKLIN RESOURCES INC | 86,500 | 1,007,000 | 1.06% | ||
| 16 | NORTHERN TRUST CORP | 80,103 | 932,000 | 0.98% | ||
| 17 | Candriam S.C.A. | 76,485 | 890,000 | 0.94% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 74,559 | 868,000 | 0.92% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 40,298 | 469,000 | 0.49% | ||
| 20 | Bank of New York Mellon Corp | 34,939 | 406,000 | 0.43% | ||
| 21 | Nationwide Fund Advisors | 34,286 | 399,000 | 0.42% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,500 | 355,000 | 0.37% | Call | |
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,937 | 337,000 | 0.36% | ||
| 24 | BlackRock Investment Management, LLC | 23,012 | 268,000 | 0.28% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 23,029 | 268,000 | 0.28% | ||
| 26 | CREDIT SUISSE AG/ | 19,695 | 229,000 | 0.24% | ||
| 27 | Swiss National Bank | 17,200 | 200,000 | 0.21% | ||
| 28 | ProShare Advisors LLC | 15,152 | 176,000 | 0.19% | ||
| 29 | TFS CAPITAL LLC | 14,703 | 171,000 | 0.18% | ||
| 30 | D. E. Shaw & Co., Inc. | 14,584 | 170,000 | 0.18% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,544 | 169,000 | 0.18% | ||
| 32 | DEARBORN PARTNERS LLC | 14,320 | 167,000 | 0.18% | ||
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 13,700 | 159,000 | 0.17% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,684 | 159,000 | 0.17% | ||
| 35 | UBS Group AG | 11,481 | 134,000 | 0.14% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,500 | 134,000 | 0.14% | ||
| 37 | GROUP ONE TRADING LLC | 11,378 | 132,000 | 0.14% | ||
| 38 | TEACHERS ADVISORS, LLC | 11,062 | 129,000 | 0.14% | ||
| 39 | A.R.T. Advisors, LLC | 10,290 | 119,000 | 0.13% | ||
| 40 | DEUTSCHE BANK AG\ | 9,971 | 115,000 | 0.12% | ||
| 41 | WELLS FARGO & COMPANY/MN | 6,963 | 80,000 | 0.08% | ||
| 42 | CITIGROUP INC | 5,616 | 65,000 | 0.07% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 4,926 | 57,339 | 0.06% | ||
| 44 | FIFTH THIRD BANCORP | 4,326 | 50,000 | 0.05% | ||
| 45 | BLACKROCK ADVISORS LLC | 3,226 | 38,000 | 0.04% | ||
| 46 | STRS OHIO | 2,700 | 31,000 | 0.03% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 2,300 | 27,000 | 0.03% | ||
| 48 | ROYAL BANK OF CANADA | 2,100 | 24,000 | 0.03% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,594 | 18,000 | 0.02% | ||
| 50 | Tower Research Capital LLC (TRC) | 1,159 | 13,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
