| 1 |
Novo Holdings A/S |
1,516,387 |
16,847,000 |
18.95% |
|
|
| 2 |
EAGLE ASSET MANAGEMENT INC |
1,238,436 |
13,759,000 |
15.47% |
|
|
| 3 |
STIFEL FINANCIAL CORP |
444,704 |
11,110,000 |
12.49% |
|
|
| 4 |
FMR LLC |
724,200 |
8,046,000 |
9.05% |
|
|
| 5 |
RA CAPITAL MANAGEMENT, L.P. |
597,363 |
6,637,000 |
7.46% |
|
|
| 6 |
HealthCor Management, L.P. |
594,534 |
6,605,000 |
7.43% |
|
|
| 7 |
BlackRock Fund Advisors |
474,023 |
5,266,000 |
5.92% |
|
|
| 8 |
VANGUARD GROUP INC |
287,842 |
3,198,000 |
3.60% |
|
|
| 9 |
EMERALD MUTUAL FUND ADVISERS TRUST |
257,090 |
2,121,000 |
2.39% |
|
|
| 10 |
BALYASNY ASSET MANAGEMENT L.P. |
138,676 |
1,541,000 |
1.73% |
|
|
| 11 |
STATE STREET CORP |
103,294 |
1,145,000 |
1.29% |
|
|
| 12 |
Cormorant Asset Management, LP |
100,300 |
1,114,000 |
1.25% |
|
|
| 13 |
FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ |
94,000 |
1,044,000 |
1.17% |
|
|
| 14 |
Mirae Asset Global Investments Co., Ltd. |
86,492 |
961,000 |
1.08% |
|
|
| 15 |
NORTHERN TRUST CORP |
80,884 |
899,000 |
1.01% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
73,754 |
819,000 |
0.92% |
|
|
| 17 |
MORGAN STANLEY |
55,825 |
620,000 |
0.70% |
|
|
| 18 |
Employees Retirement System of Texas |
50,000 |
556,000 |
0.63% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
42,938 |
477,000 |
0.54% |
|
|
| 20 |
Bank of New York Mellon Corp |
34,914 |
388,000 |
0.44% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
34,700 |
386,000 |
0.43% |
Put |
|
| 22 |
EMERALD ADVISERS, LLC |
42,910 |
354,000 |
0.40% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
31,650 |
352,000 |
0.40% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
28,937 |
321,000 |
0.36% |
|
|
| 25 |
CREDIT SUISSE AG/ |
27,751 |
309,000 |
0.35% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,600 |
284,000 |
0.32% |
Call |
|
| 27 |
Connor, Clark & Lunn Investment Management Ltd. |
23,900 |
266,000 |
0.30% |
|
|
| 28 |
BlackRock Investment Management, LLC |
22,506 |
250,000 |
0.28% |
|
|
| 29 |
ROYAL BANK OF CANADA |
21,012 |
234,000 |
0.26% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
20,895 |
233,000 |
0.26% |
|
|
| 31 |
MILLENNIUM MANAGEMENT LLC |
20,328 |
226,000 |
0.25% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
19,019 |
211,000 |
0.24% |
|
|
| 33 |
DEARBORN PARTNERS LLC |
18,020 |
200,000 |
0.22% |
|
|
| 34 |
ProShare Advisors LLC |
17,902 |
199,000 |
0.22% |
|
|
| 35 |
Swiss National Bank |
17,200 |
191,000 |
0.21% |
|
|
| 36 |
A.R.T. Advisors, LLC |
17,002 |
188,000 |
0.21% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,544 |
162,000 |
0.18% |
|
|
| 38 |
GROUP ONE TRADING LLC |
12,775 |
142,000 |
0.16% |
|
|
| 39 |
Rotella Capital Management, Inc. |
12,500 |
139,000 |
0.16% |
|
|
| 40 |
UBS Group AG |
11,876 |
132,000 |
0.15% |
|
|
| 41 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,659 |
130,000 |
0.15% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
11,062 |
123,000 |
0.14% |
|
|
| 43 |
ALPS ADVISORS INC |
10,041 |
112,000 |
0.13% |
|
|
| 44 |
DekaBank Deutsche Girozentrale |
9,500 |
106,000 |
0.12% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
8,113 |
91,000 |
0.10% |
|
|
| 46 |
Nationwide Fund Advisors |
5,580 |
62,000 |
0.07% |
|
|
| 47 |
FIFTH THIRD BANCORP |
5,100 |
57,000 |
0.06% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,926 |
54,728 |
0.06% |
|
|
| 49 |
DEUTSCHE BANK AG\ |
4,417 |
49,000 |
0.06% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
3,686 |
41,000 |
0.05% |
|
|
