| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 12,675,427 | 189,244,000 | 16.64% | ||
| 2 | FMR LLC | 12,188,461 | 181,973,000 | 16.00% | ||
| 3 | Clearbridge Investments, LLC | 9,298,289 | 138,823,000 | 12.21% | ||
| 4 | VANGUARD GROUP INC | 5,243,545 | 78,286,000 | 6.88% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 3,623,786 | 54,103,000 | 4.76% | ||
| 6 | FIRST TRUST ADVISORS LP | 3,608,918 | 53,881,000 | 4.74% | ||
| 7 | BlackRock Fund Advisors | 3,185,688 | 47,562,000 | 4.18% | ||
| 8 | BB BIOTECH AG | 3,165,816 | 47,266,000 | 4.16% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 3,126,551 | 46,679,000 | 4.11% | ||
| 10 | STATE STREET CORP | 2,611,643 | 38,993,000 | 3.43% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,470,653 | 36,887,000 | 3.24% | ||
| 12 | NORGES BANK | 1,608,562 | 24,017,000 | 2.11% | ||
| 13 | Artal Group S.A. | 1,300,000 | 19,409,000 | 1.71% | ||
| 14 | NORTHERN TRUST CORP | 1,158,722 | 17,300,000 | 1.52% | ||
| 15 | Invesco Ltd. | 733,259 | 10,948,000 | 0.96% | ||
| 16 | WELLS FARGO & COMPANY/MN | 699,783 | 10,448,000 | 0.92% | ||
| 17 | Granahan Investment Management, LLC | 540,641 | 8,072,000 | 0.71% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 480,420 | 7,172,000 | 0.63% | ||
| 19 | Bank of New York Mellon Corp | 435,771 | 6,506,000 | 0.57% | ||
| 20 | DEUTSCHE BANK AG\ | 362,827 | 5,416,000 | 0.48% | ||
| 21 | Artal Group S.A. | 350,000 | 5,226,000 | 0.46% | Call | |
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 346,028 | 5,166,000 | 0.45% | ||
| 23 | MANAGED ACCOUNT ADVISORS LLC | 325,685 | 4,863,000 | 0.43% | ||
| 24 | MORGAN STANLEY | 317,128 | 4,735,000 | 0.42% | ||
| 25 | MACQUARIE GROUP LTD | 268,077 | 4,002,000 | 0.35% | ||
| 26 | GUGGENHEIM CAPITAL LLC | 249,520 | 3,726,000 | 0.33% | ||
| 27 | BlackRock Investment Management, LLC | 246,462 | 3,680,000 | 0.32% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 233,055 | 3,480,000 | 0.31% | ||
| 29 | RAYMOND JAMES & ASSOCIATES | 222,239 | 3,318,000 | 0.29% | ||
| 30 | PRUDENTIAL FINANCIAL INC | 212,532 | 3,173,000 | 0.28% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 206,950 | 3,090,000 | 0.27% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,900 | 2,775,000 | 0.24% | Put | |
| 33 | ALLIANCEBERNSTEIN L.P. | 167,451 | 2,500,000 | 0.22% | ||
| 34 | CREDIT SUISSE AG/ | 165,210 | 2,466,000 | 0.22% | ||
| 35 | MASON STREET ADVISORS, LLC | 154,800 | 2,311,000 | 0.20% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 153,636 | 2,294,000 | 0.20% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,700 | 2,280,000 | 0.20% | Call | |
| 38 | ProShare Advisors LLC | 151,141 | 2,257,000 | 0.20% | ||
| 39 | TWIN FOCUS CAPITAL PARTNERS, LLC | 140,000 | 2,090,000 | 0.18% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 136,000 | 1,882,000 | 0.17% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,654 | 1,876,000 | 0.16% | ||
| 42 | TEACHERS ADVISORS, LLC | 122,861 | 1,834,000 | 0.16% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 114,050 | 1,703,000 | 0.15% | ||
| 44 | BARCLAYS PLC | 110,037 | 1,540,000 | 0.14% | ||
| 45 | RHUMBLINE ADVISERS | 100,037 | 1,494,000 | 0.13% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 100,000 | 1,493,000 | 0.13% | ||
| 47 | Nationwide Fund Advisors | 99,914 | 1,492,000 | 0.13% | ||
| 48 | CITADEL ADVISORS LLC | 97,943 | 1,462,000 | 0.13% | ||
| 49 | Swiss National Bank | 95,800 | 1,430,000 | 0.13% | ||
| 50 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 86,311 | 1,289,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
