| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 12,127,073 | 73,975,000 | 17.28% | ||
| 2 | Clearbridge Investments, LLC | 11,436,364 | 69,762,000 | 16.29% | ||
| 3 | FMR LLC | 9,416,641 | 57,442,000 | 13.42% | ||
| 4 | VANGUARD GROUP INC | 5,310,180 | 32,392,000 | 7.57% | ||
| 5 | BB BIOTECH AG | 3,240,816 | 19,769,000 | 4.62% | ||
| 6 | BlackRock Fund Advisors | 3,180,214 | 19,399,000 | 4.53% | ||
| 7 | STATE STREET CORP | 3,141,312 | 19,162,000 | 4.48% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,424,673 | 14,791,000 | 3.45% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,489,435 | 9,086,000 | 2.12% | ||
| 10 | NORGES BANK | 1,481,153 | 9,035,000 | 2.11% | ||
| 11 | Artal Group S.A. | 1,000,000 | 6,100,000 | 1.42% | Call | |
| 12 | MORGAN STANLEY | 998,544 | 6,091,000 | 1.42% | ||
| 13 | WELLS FARGO & COMPANY/MN | 971,606 | 5,927,000 | 1.38% | ||
| 14 | NORTHERN TRUST CORP | 968,261 | 5,906,000 | 1.38% | ||
| 15 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 771,842 | 4,708,000 | 1.10% | ||
| 16 | D. E. Shaw & Co., Inc. | 625,169 | 3,814,000 | 0.89% | ||
| 17 | DEUTSCHE BANK AG\ | 540,521 | 3,296,000 | 0.77% | ||
| 18 | MANAGED ACCOUNT ADVISORS LLC | 535,536 | 3,266,000 | 0.76% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 533,652 | 3,254,000 | 0.76% | ||
| 20 | Candriam S.C.A. | 485,000 | 2,959,000 | 0.69% | ||
| 21 | Bank of New York Mellon Corp | 473,890 | 2,891,000 | 0.68% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 458,276 | 2,795,000 | 0.65% | ||
| 23 | RAYMOND JAMES & ASSOCIATES | 413,978 | 2,525,000 | 0.59% | ||
| 24 | Granahan Investment Management, LLC | 413,800 | 2,524,000 | 0.59% | ||
| 25 | Numeric Investors LLC | 306,189 | 1,868,000 | 0.44% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 305,215 | 1,862,000 | 0.43% | ||
| 27 | GUGGENHEIM CAPITAL LLC | 301,045 | 1,836,000 | 0.43% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 300,000 | 1,830,000 | 0.43% | Put | |
| 29 | MACQUARIE GROUP LTD | 290,000 | 1,769,000 | 0.41% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 261,655 | 1,597,000 | 0.37% | ||
| 31 | MARINER INVESTMENT GROUP LLC | 258,000 | 1,574,000 | 0.37% | ||
| 32 | A.R.T. Advisors, LLC | 242,432 | 1,478,000 | 0.35% | ||
| 33 | BlackRock Investment Management, LLC | 234,286 | 1,429,000 | 0.33% | ||
| 34 | GOLDMAN SACHS GROUP INC | 226,271 | 1,380,000 | 0.32% | ||
| 35 | GOLDMAN SACHS GROUP INC | 202,500 | 1,235,000 | 0.29% | Call | |
| 36 | CITADEL ADVISORS LLC | 187,152 | 1,142,000 | 0.27% | ||
| 37 | CREDIT SUISSE AG/ | 186,169 | 1,136,000 | 0.27% | ||
| 38 | Jefferies Group LLC | 173,341 | 1,057,000 | 0.25% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 164,734 | 1,005,000 | 0.23% | ||
| 40 | BARCLAYS PLC | 166,216 | 997,000 | 0.23% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 162,840 | 993,000 | 0.23% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 159,112 | 971,000 | 0.23% | ||
| 43 | BB&T SECURITIES, LLC | 15,684 | 956,000 | 0.22% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,300 | 917,000 | 0.21% | Put | |
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 136,000 | 874,000 | 0.20% | ||
| 46 | TWIN FOCUS CAPITAL PARTNERS, LLC | 140,102 | 855,000 | 0.20% | ||
| 47 | TEACHERS ADVISORS, LLC | 121,995 | 744,000 | 0.17% | ||
| 48 | Spark Investment Management LLC | 116,500 | 710,000 | 0.17% | ||
| 49 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 114,050 | 696,000 | 0.16% | ||
| 50 | Lumbard & Kellner, LLC | 109,635 | 669,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
