| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 11,918,396 | 126,216,000 | 15.96% | ||
| 2 | Clearbridge Investments, LLC | 10,967,847 | 116,149,000 | 14.68% | ||
| 3 | FMR LLC | 10,260,241 | 108,656,000 | 13.74% | ||
| 4 | FIRST TRUST ADVISORS LP | 5,811,998 | 61,549,000 | 7.78% | ||
| 5 | VANGUARD GROUP INC | 5,175,126 | 54,805,000 | 6.93% | ||
| 6 | BB BIOTECH AG | 3,165,816 | 33,526,000 | 4.24% | ||
| 7 | BlackRock Fund Advisors | 2,921,181 | 30,935,000 | 3.91% | ||
| 8 | STATE STREET CORP | 2,815,046 | 29,809,000 | 3.77% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,403,589 | 25,454,000 | 3.22% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 2,269,597 | 24,035,000 | 3.04% | ||
| 11 | Artal Group S.A. | 1,500,000 | 15,885,000 | 2.01% | ||
| 12 | NORTHERN TRUST CORP | 1,000,721 | 10,598,000 | 1.34% | ||
| 13 | MORGAN STANLEY | 995,994 | 10,547,000 | 1.33% | ||
| 14 | Invesco Ltd. | 930,633 | 9,855,000 | 1.25% | ||
| 15 | WELLS FARGO & COMPANY/MN | 876,418 | 9,281,000 | 1.17% | ||
| 16 | NORGES BANK | 839,562 | 8,891,000 | 1.12% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 633,248 | 6,706,000 | 0.85% | ||
| 18 | Granahan Investment Management, LLC | 520,332 | 5,510,000 | 0.70% | ||
| 19 | MANAGED ACCOUNT ADVISORS LLC | 485,595 | 5,142,000 | 0.65% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 479,387 | 5,076,000 | 0.64% | ||
| 21 | Bank of New York Mellon Corp | 451,497 | 4,781,000 | 0.60% | ||
| 22 | DEUTSCHE BANK AG\ | 402,073 | 4,256,000 | 0.54% | ||
| 23 | Artal Group S.A. | 400,000 | 4,236,000 | 0.54% | Call | |
| 24 | RENAISSANCE TECHNOLOGIES LLC | 370,446 | 3,923,000 | 0.50% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 334,835 | 3,546,000 | 0.45% | ||
| 26 | MACQUARIE GROUP LTD | 290,000 | 3,071,000 | 0.39% | ||
| 27 | RAYMOND JAMES & ASSOCIATES | 289,233 | 3,063,000 | 0.39% | ||
| 28 | GUGGENHEIM CAPITAL LLC | 245,170 | 2,596,000 | 0.33% | ||
| 29 | BlackRock Investment Management, LLC | 236,217 | 2,502,000 | 0.32% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 228,465 | 2,420,000 | 0.31% | ||
| 31 | GOLDMAN SACHS GROUP INC | 218,778 | 2,317,000 | 0.29% | ||
| 32 | Rhenman & Partners Asset Management AB | 180,000 | 1,906,000 | 0.24% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 176,019 | 1,864,000 | 0.24% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 167,440 | 1,773,000 | 0.22% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 158,435 | 1,678,000 | 0.21% | ||
| 36 | PICTET ASSET MANAGEMENT LTD | 157,150 | 1,664,000 | 0.21% | ||
| 37 | MARINER INVESTMENT GROUP LLC | 155,500 | 1,647,000 | 0.21% | ||
| 38 | MASON STREET ADVISORS, LLC | 154,800 | 1,639,000 | 0.21% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 146,500 | 1,551,000 | 0.20% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 145,500 | 1,541,000 | 0.19% | ||
| 41 | TWIN FOCUS CAPITAL PARTNERS, LLC | 140,480 | 1,488,000 | 0.19% | ||
| 42 | BARCLAYS PLC | 145,149 | 1,451,000 | 0.18% | ||
| 43 | CITADEL ADVISORS LLC | 129,004 | 1,366,000 | 0.17% | ||
| 44 | TEACHERS ADVISORS, LLC | 121,995 | 1,292,000 | 0.16% | ||
| 45 | GOLDMAN SACHS GROUP INC | 119,000 | 1,260,000 | 0.16% | Call | |
| 46 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 114,050 | 1,208,000 | 0.15% | ||
| 47 | BB&T SECURITIES, LLC | 10,757 | 1,139,000 | 0.14% | ||
| 48 | SMITH ASSET MANAGEMENT GROUP LP | 107,270 | 1,136,000 | 0.14% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,800 | 1,078,000 | 0.14% | Put | |
| 50 | Nationwide Fund Advisors | 101,037 | 1,070,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
