| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 11,922,396 | 141,280,000 | 16.13% | ||
| 2 | FMR LLC | 11,640,950 | 137,945,000 | 15.75% | ||
| 3 | Clearbridge Investments, LLC | 9,980,315 | 118,267,000 | 13.51% | ||
| 4 | VANGUARD GROUP INC | 5,201,812 | 61,641,000 | 7.04% | ||
| 5 | FIRST TRUST ADVISORS LP | 4,121,730 | 48,843,000 | 5.58% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 3,218,276 | 38,137,000 | 4.36% | ||
| 7 | BB BIOTECH AG | 3,165,816 | 37,515,000 | 4.28% | ||
| 8 | BlackRock Fund Advisors | 2,933,416 | 34,761,000 | 3.97% | ||
| 9 | STATE STREET CORP | 2,535,747 | 30,049,000 | 3.43% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,444,049 | 28,962,000 | 3.31% | ||
| 11 | Artal Group S.A. | 1,500,000 | 17,775,000 | 2.03% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 1,307,500 | 15,495,000 | 1.77% | ||
| 13 | NORGES BANK | 1,089,562 | 12,911,000 | 1.47% | ||
| 14 | NORTHERN TRUST CORP | 997,714 | 11,822,000 | 1.35% | ||
| 15 | MORGAN STANLEY | 826,965 | 9,800,000 | 1.12% | ||
| 16 | WELLS FARGO & COMPANY/MN | 770,123 | 9,126,000 | 1.04% | ||
| 17 | DEUTSCHE BANK AG\ | 593,127 | 7,027,000 | 0.80% | ||
| 18 | Artal Group S.A. | 550,000 | 6,518,000 | 0.74% | Call | |
| 19 | Granahan Investment Management, LLC | 521,052 | 6,174,000 | 0.71% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 482,071 | 5,712,000 | 0.65% | ||
| 21 | Bank of New York Mellon Corp | 423,744 | 5,021,000 | 0.57% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 415,440 | 4,923,000 | 0.56% | ||
| 23 | MANAGED ACCOUNT ADVISORS LLC | 375,989 | 4,456,000 | 0.51% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 360,490 | 4,272,000 | 0.49% | ||
| 25 | MACQUARIE GROUP LTD | 265,000 | 3,140,000 | 0.36% | ||
| 26 | RAYMOND JAMES & ASSOCIATES | 261,155 | 3,095,000 | 0.35% | ||
| 27 | BlackRock Investment Management, LLC | 234,797 | 2,782,000 | 0.32% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 232,205 | 2,752,000 | 0.31% | ||
| 29 | CREDIT SUISSE AG/ | 228,725 | 2,709,000 | 0.31% | ||
| 30 | GUGGENHEIM CAPITAL LLC | 219,218 | 2,598,000 | 0.30% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 204,150 | 2,419,000 | 0.28% | ||
| 32 | PRUDENTIAL FINANCIAL INC | 173,688 | 2,058,000 | 0.24% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 167,440 | 1,984,000 | 0.23% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 156,636 | 1,856,000 | 0.21% | ||
| 35 | MASON STREET ADVISORS, LLC | 154,800 | 1,834,000 | 0.21% | ||
| 36 | CITADEL ADVISORS LLC | 152,048 | 1,802,000 | 0.21% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 147,994 | 1,754,000 | 0.20% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,700 | 1,691,000 | 0.19% | ||
| 39 | TWIN FOCUS CAPITAL PARTNERS, LLC | 140,000 | 1,659,000 | 0.19% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,300 | 1,591,000 | 0.18% | Put | |
| 41 | MARINER INVESTMENT GROUP LLC | 130,800 | 1,550,000 | 0.18% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 130,012 | 1,540,000 | 0.18% | ||
| 43 | TEACHERS ADVISORS, LLC | 121,995 | 1,446,000 | 0.17% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 120,300 | 1,426,000 | 0.16% | Call | |
| 45 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 114,050 | 1,351,000 | 0.15% | ||
| 46 | Nationwide Fund Advisors | 100,710 | 1,193,000 | 0.14% | ||
| 47 | Perigon Wealth Management, LLC | 100,000 | 1,185,000 | 0.14% | ||
| 48 | Rhenman & Partners Asset Management AB | 98,702 | 1,170,000 | 0.13% | ||
| 49 | Swiss National Bank | 95,800 | 1,135,000 | 0.13% | ||
| 50 | ProShare Advisors LLC | 93,917 | 1,113,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
