| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 253,372,135 | 438,334,000 | 53.91% | ||
| 2 | FMR LLC | 77,068,554 | 133,329,000 | 16.40% | ||
| 3 | Ulys, L.L.C. | 29,782,609 | 51,524,000 | 6.34% | ||
| 4 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 18,989,192 | 32,851,000 | 4.04% | ||
| 5 | VANGUARD GROUP INC | 13,960,930 | 24,152,000 | 2.97% | ||
| 6 | BlackRock Fund Advisors | 12,079,535 | 20,898,000 | 2.57% | ||
| 7 | NEA Management Company, LLC | 11,676,000 | 20,199,000 | 2.48% | ||
| 8 | STATE STREET CORP | 7,614,432 | 13,172,000 | 1.62% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 7,336,791 | 12,693,000 | 1.56% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,454,690 | 11,167,000 | 1.37% | ||
| 11 | ROYCE & ASSOCIATES LP | 4,233,933 | 7,325,000 | 0.90% | ||
| 12 | SCHRODER INVESTMENT MANAGEMENT GROUP | 3,241,100 | 5,607,103 | 0.69% | ||
| 13 | NORTHERN TRUST CORP | 2,960,305 | 5,122,000 | 0.63% | ||
| 14 | NORGES BANK | 2,537,147 | 4,389,000 | 0.54% | ||
| 15 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 2,083,200 | 3,604,000 | 0.44% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 1,722,131 | 2,979,000 | 0.37% | ||
| 17 | Bank of New York Mellon Corp | 1,285,293 | 2,224,000 | 0.27% | ||
| 18 | TIAA CREF INVESTMENT MANAGEMENT LLC | 905,488 | 1,566,000 | 0.19% | ||
| 19 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,002 | 1,236,000 | 0.15% | ||
| 20 | BlackRock Investment Management, LLC | 644,884 | 1,116,000 | 0.14% | ||
| 21 | ProShare Advisors LLC | 623,250 | 1,078,000 | 0.13% | ||
| 22 | CITY NATIONAL BANK | 584,753 | 1,011,000 | 0.12% | ||
| 23 | ALLIANCEBERNSTEIN L.P. | 496,391 | 859,000 | 0.11% | ||
| 24 | AXA S.A. | 468,701 | 811,000 | 0.10% | ||
| 25 | GABELLI FUNDS LLC | 452,000 | 782,000 | 0.10% | ||
| 26 | ROYAL LONDON ASSET MANAGEMENT LTD | 521,800 | 772,000 | 0.09% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 467,300 | 771,000 | 0.09% | ||
| 28 | STIFEL FINANCIAL CORP | 438,458 | 759,000 | 0.09% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 411,395 | 712,000 | 0.09% | ||
| 30 | Invesco Ltd. | 372,485 | 644,000 | 0.08% | ||
| 31 | TEACHERS ADVISORS, LLC | 329,241 | 570,000 | 0.07% | ||
| 32 | DEUTSCHE BANK AG\ | 317,511 | 548,000 | 0.07% | ||
| 33 | DekaBank Deutsche Girozentrale | 312,400 | 540,000 | 0.07% | ||
| 34 | Rhenman & Partners Asset Management AB | 294,805 | 510,000 | 0.06% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 281,606 | 487,000 | 0.06% | ||
| 36 | LOS ANGELES CAPITAL MANAGEMENT LLC | 278,129 | 481,000 | 0.06% | ||
| 37 | Swiss National Bank | 274,500 | 475,000 | 0.06% | ||
| 38 | PUTNAM INVESTMENTS LLC | 260,224 | 450,000 | 0.06% | ||
| 39 | CREDIT SUISSE AG/ | 252,973 | 437,000 | 0.05% | ||
| 40 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 250,000 | 433,000 | 0.05% | ||
| 41 | Teton Advisors, Inc. | 235,000 | 407,000 | 0.05% | ||
| 42 | RHUMBLINE ADVISERS | 211,224 | 365,000 | 0.04% | ||
| 43 | WILLIAM HARRIS INVESTORS INC | 204,342 | 354,000 | 0.04% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 184,091 | 318,000 | 0.04% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 182,992 | 317,000 | 0.04% | ||
| 46 | Nationwide Fund Advisors | 175,129 | 303,000 | 0.04% | ||
| 47 | BLACKROCK ADVISORS LLC | 165,530 | 286,000 | 0.04% | ||
| 48 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 161,392 | 279,000 | 0.03% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 156,574 | 270,873 | 0.03% | ||
| 50 | Round Table Services, LLC | 151,280 | 262,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
