| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 402,625,866 | 378,492,000 | 57.86% | ||
| 2 | FMR LLC | 107,075,179 | 101,111,000 | 15.46% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 38,301,688 | 36,169,000 | 5.53% | ||
| 4 | Ulys, L.L.C. | 30,248,505 | 28,434,000 | 4.35% | ||
| 5 | VANGUARD GROUP INC | 19,059,692 | 17,998,000 | 2.75% | ||
| 6 | NEA Management Company, LLC | 16,676,000 | 15,675,000 | 2.40% | ||
| 7 | BlackRock Fund Advisors | 15,466,996 | 14,605,000 | 2.23% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 8,130,168 | 7,677,000 | 1.17% | ||
| 9 | MASTERS CAPITAL MANAGEMENT LLC | 7,964,370 | 7,521,000 | 1.15% | ||
| 10 | SABBY MANAGEMENT, LLC | 5,371,800 | 5,073,000 | 0.78% | ||
| 11 | STATE STREET CORP | 3,802,455 | 3,589,000 | 0.55% | ||
| 12 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 3,713,500 | 3,507,000 | 0.54% | ||
| 13 | SCHRODER INVESTMENT MANAGEMENT GROUP | 3,045,416 | 2,895,000 | 0.44% | ||
| 14 | ROYCE & ASSOCIATES LP | 2,813,833 | 2,657,000 | 0.41% | ||
| 15 | NORTHERN TRUST CORP | 2,695,286 | 2,545,000 | 0.39% | ||
| 16 | SHANDA ASSET MANAGEMENT HOLDINGS Ltd | 2,586,881 | 2,432,000 | 0.37% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 1,883,842 | 1,778,000 | 0.27% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 1,636,131 | 1,545,000 | 0.24% | ||
| 19 | Rhenman & Partners Asset Management AB | 1,594,805 | 1,506,000 | 0.23% | ||
| 20 | Bank of New York Mellon Corp | 1,485,721 | 1,403,000 | 0.21% | ||
| 21 | NORGES BANK | 1,110,689 | 1,049,000 | 0.16% | ||
| 22 | ALDEN GLOBAL CAPITAL LLC | 900,900 | 851,000 | 0.13% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 893,599 | 844,000 | 0.13% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 855,603 | 808,000 | 0.12% | ||
| 25 | TIAA CREF TRUST CO FSB/MO | 804,950 | 760,000 | 0.12% | ||
| 26 | SMITH ASSET MANAGEMENT GROUP LP | 746,560 | 705,000 | 0.11% | ||
| 27 | BlackRock Investment Management, LLC | 686,856 | 649,000 | 0.10% | ||
| 28 | JACOBS LEVY EQUITY MANAGEMENT, INC | 645,379 | 609,000 | 0.09% | ||
| 29 | ProShare Advisors LLC | 632,020 | 597,000 | 0.09% | ||
| 30 | DEUTSCHE BANK AG\ | 589,466 | 554,000 | 0.08% | ||
| 31 | Candriam S.C.A. | 570,000 | 538,000 | 0.08% | ||
| 32 | CREDIT SUISSE AG/ | 554,541 | 524,000 | 0.08% | ||
| 33 | MARSHALL WACE, LLP | 536,686 | 507,000 | 0.08% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 499,973 | 472,000 | 0.07% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 467,300 | 439,000 | 0.07% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 455,593 | 430,000 | 0.07% | ||
| 37 | Swiss National Bank | 406,100 | 383,000 | 0.06% | ||
| 38 | TEACHERS ADVISORS, LLC | 367,741 | 347,000 | 0.05% | ||
| 39 | HOWARD HUGHES MEDICAL INSTITUTE | 360,643 | 340,000 | 0.05% | ||
| 40 | DekaBank Deutsche Girozentrale | 339,400 | 320,000 | 0.05% | ||
| 41 | MANAGED ACCOUNT ADVISORS LLC | 321,427 | 303,000 | 0.05% | ||
| 42 | STIFEL FINANCIAL CORP | 285,575 | 270,000 | 0.04% | ||
| 43 | WILLIAM HARRIS INVESTORS INC | 276,471 | 261,000 | 0.04% | ||
| 44 | MARINER INVESTMENT GROUP LLC | 271,656 | 257,000 | 0.04% | ||
| 45 | RHUMBLINE ADVISERS | 264,723 | 250,000 | 0.04% | ||
| 46 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 250,000 | 228,000 | 0.03% | ||
| 47 | MORGAN STANLEY | 230,296 | 218,000 | 0.03% | ||
| 48 | Jefferies Group LLC | 199,814 | 188,000 | 0.03% | ||
| 49 | GOLDMAN SACHS GROUP INC | 192,905 | 182,000 | 0.03% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 190,161 | 180,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
