| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 402,625,866 | 366,389,000 | 57.70% | ||
| 2 | FMR LLC | 107,075,179 | 97,428,000 | 15.34% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34,438,743 | 31,335,000 | 4.94% | ||
| 4 | Ulys, L.L.C. | 30,248,505 | 27,526,000 | 4.34% | ||
| 5 | VANGUARD GROUP INC | 17,841,908 | 16,234,000 | 2.56% | ||
| 6 | NEA Management Company, LLC | 16,676,000 | 15,175,000 | 2.39% | ||
| 7 | BlackRock Fund Advisors | 12,376,532 | 11,261,000 | 1.77% | ||
| 8 | ROYAL LONDON ASSET MANAGEMENT LTD | 1,021,900 | 8,860,000 | 1.40% | ||
| 9 | MASTERS CAPITAL MANAGEMENT LLC | 8,000,000 | 7,279,000 | 1.15% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 7,660,189 | 6,970,000 | 1.10% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,073,590 | 5,526,000 | 0.87% | ||
| 12 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 4,048,900 | 3,684,000 | 0.58% | ||
| 13 | STATE STREET CORP | 3,748,388 | 3,413,000 | 0.54% | ||
| 14 | SCHRODER INVESTMENT MANAGEMENT GROUP | 3,045,416 | 2,771,000 | 0.44% | ||
| 15 | ROYCE & ASSOCIATES LP | 2,813,833 | 2,560,000 | 0.40% | ||
| 16 | NORTHERN TRUST CORP | 2,687,951 | 2,446,000 | 0.39% | ||
| 17 | SHANDA ASSET MANAGEMENT HOLDINGS Ltd | 2,586,881 | 2,354,000 | 0.37% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 1,817,134 | 1,653,000 | 0.26% | ||
| 19 | TIAA CREF TRUST CO FSB/MO | 1,813,074 | 1,650,000 | 0.26% | ||
| 20 | Rhenman & Partners Asset Management AB | 1,594,805 | 1,451,000 | 0.23% | ||
| 21 | Bank of New York Mellon Corp | 1,316,731 | 1,198,000 | 0.19% | ||
| 22 | NORGES BANK | 1,228,011 | 1,118,000 | 0.18% | ||
| 23 | JACOBS LEVY EQUITY MANAGEMENT, INC | 1,128,034 | 1,026,000 | 0.16% | ||
| 24 | MORGAN STANLEY | 963,698 | 876,000 | 0.14% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 855,603 | 779,000 | 0.12% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 850,066 | 774,000 | 0.12% | ||
| 27 | SMITH ASSET MANAGEMENT GROUP LP | 807,860 | 735,000 | 0.12% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 695,910 | 633,000 | 0.10% | ||
| 29 | BlackRock Investment Management, LLC | 673,396 | 613,000 | 0.10% | ||
| 30 | Candriam S.C.A. | 570,000 | 519,000 | 0.08% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 467,300 | 439,000 | 0.07% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 466,393 | 424,000 | 0.07% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 454,273 | 413,000 | 0.07% | ||
| 34 | TWO SIGMA INVESTMENTS, LP | 404,684 | 368,000 | 0.06% | ||
| 35 | GLG LLC | 398,496 | 363,000 | 0.06% | ||
| 36 | ProShare Advisors LLC | 394,666 | 359,000 | 0.06% | ||
| 37 | Invesco Ltd. | 380,007 | 346,000 | 0.05% | ||
| 38 | CREDIT SUISSE AG/ | 373,562 | 340,000 | 0.05% | ||
| 39 | HOWARD HUGHES MEDICAL INSTITUTE | 360,643 | 328,000 | 0.05% | ||
| 40 | GABELLI FUNDS LLC | 351,000 | 319,000 | 0.05% | ||
| 41 | GOLDMAN SACHS GROUP INC | 346,931 | 316,000 | 0.05% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 331,782 | 302,000 | 0.05% | ||
| 43 | Swiss National Bank | 325,300 | 296,000 | 0.05% | ||
| 44 | TEACHERS ADVISORS, LLC | 320,121 | 291,000 | 0.05% | ||
| 45 | STIFEL FINANCIAL CORP | 296,375 | 270,000 | 0.04% | ||
| 46 | WILLIAM HARRIS INVESTORS INC | 276,471 | 252,000 | 0.04% | ||
| 47 | MARINER INVESTMENT GROUP LLC | 271,656 | 247,000 | 0.04% | ||
| 48 | DekaBank Deutsche Girozentrale | 275,900 | 239,000 | 0.04% | ||
| 49 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 250,000 | 228,000 | 0.04% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 239,186 | 218,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
