| 1 |
Artal Group S.A. |
253,372,135 |
357,255,000 |
54.34% |
|
|
| 2 |
FMR LLC |
77,222,724 |
108,884,000 |
16.56% |
|
|
| 3 |
Ulys, L.L.C. |
29,782,609 |
41,993,000 |
6.39% |
|
|
| 4 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
23,479,178 |
33,106,000 |
5.04% |
|
|
| 5 |
VANGUARD GROUP INC |
14,738,155 |
20,782,000 |
3.16% |
|
|
| 6 |
NEA Management Company, LLC |
11,676,000 |
16,463,000 |
2.50% |
|
|
| 7 |
BlackRock Fund Advisors |
11,191,158 |
15,780,000 |
2.40% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
7,354,528 |
10,370,000 |
1.58% |
|
|
| 9 |
PRICE T ROWE ASSOCIATES INC /MD/ |
6,146,590 |
8,667,000 |
1.32% |
|
|
| 10 |
STATE STREET CORP |
3,626,314 |
5,114,000 |
0.78% |
|
|
| 11 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
3,045,416 |
4,294,037 |
0.65% |
|
|
| 12 |
ROYCE & ASSOCIATES LP |
2,736,133 |
3,858,000 |
0.59% |
|
|
| 13 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
2,592,900 |
3,656,000 |
0.56% |
|
|
| 14 |
NORTHERN TRUST CORP |
2,570,782 |
3,625,000 |
0.55% |
|
|
| 15 |
NORGES BANK |
2,537,147 |
3,577,000 |
0.54% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
1,753,988 |
2,473,000 |
0.38% |
|
|
| 17 |
Bank of New York Mellon Corp |
1,335,046 |
1,882,000 |
0.29% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
869,194 |
1,226,000 |
0.19% |
|
|
| 19 |
BlackRock Investment Management, LLC |
644,278 |
908,000 |
0.14% |
|
|
| 20 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
595,650 |
840,000 |
0.13% |
|
|
| 21 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
500,000 |
805,000 |
0.12% |
|
|
| 22 |
ROYAL LONDON ASSET MANAGEMENT LTD |
502,400 |
723,000 |
0.11% |
|
|
| 23 |
ALLIANCEBERNSTEIN L.P. |
486,773 |
686,000 |
0.10% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
467,300 |
659,000 |
0.10% |
|
|
| 25 |
GABELLI FUNDS LLC |
452,000 |
637,000 |
0.10% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
421,890 |
595,000 |
0.09% |
|
|
| 27 |
Invesco Ltd. |
370,957 |
523,000 |
0.08% |
|
|
| 28 |
ProShare Advisors LLC |
355,937 |
502,000 |
0.08% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
320,121 |
451,000 |
0.07% |
|
|
| 30 |
DekaBank Deutsche Girozentrale |
301,400 |
425,000 |
0.06% |
|
|
| 31 |
Rhenman & Partners Asset Management AB |
294,805 |
416,000 |
0.06% |
|
|
| 32 |
Swiss National Bank |
295,300 |
416,000 |
0.06% |
|
|
| 33 |
STIFEL FINANCIAL CORP |
282,589 |
398,000 |
0.06% |
|
|
| 34 |
RHUMBLINE ADVISERS |
209,748 |
296,000 |
0.05% |
|
|
| 35 |
WILLIAM HARRIS INVESTORS INC |
204,342 |
288,000 |
0.04% |
|
|
| 36 |
METROPOLITAN LIFE INSURANCE CO/NY |
188,541 |
266,000 |
0.04% |
|
|
| 37 |
Nationwide Fund Advisors |
177,141 |
250,000 |
0.04% |
|
|
| 38 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
161,392 |
228,000 |
0.03% |
|
|
| 39 |
GAMCO INVESTORS, INC. ET AL |
160,200 |
226,000 |
0.03% |
|
|
| 40 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
159,797 |
225,000 |
0.03% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
151,382 |
213,449 |
0.03% |
|
|
| 42 |
Round Table Services, LLC |
151,280 |
213,000 |
0.03% |
|
|
| 43 |
MORGAN STANLEY |
148,749 |
210,000 |
0.03% |
|
|
| 44 |
CITADEL ADVISORS LLC |
141,150 |
199,000 |
0.03% |
|
|
| 45 |
BLACKROCK ADVISORS LLC |
138,836 |
196,000 |
0.03% |
|
|
| 46 |
VOYA INVESTMENT MANAGEMENT LLC |
139,200 |
196,000 |
0.03% |
|
|
| 47 |
CREDIT SUISSE AG/ |
132,344 |
187,000 |
0.03% |
|
|
| 48 |
KLINGENSTEIN FIELDS & CO LP |
120,000 |
169,000 |
0.03% |
|
|
| 49 |
TFS CAPITAL LLC |
116,089 |
164,000 |
0.02% |
|
|
| 50 |
BANK OF AMERICA CORP /DE/ |
106,865 |
151,000 |
0.02% |
|
|
