| 1 |
Essex Woodlands Management, Inc. |
9,353,304 |
52,659,000 |
47.29% |
|
|
| 2 |
Broadfin Capital, LLC |
1,919,721 |
10,808,000 |
9.71% |
|
|
| 3 |
GOLDMAN SACHS GROUP INC |
1,606,980 |
9,047,000 |
8.13% |
|
|
| 4 |
SENZAR ASSET MANAGEMENT, LLC |
1,603,066 |
9,025,262 |
8.11% |
|
|
| 5 |
TAMARACK ADVISERS, LP |
1,065,000 |
6,124,000 |
5.50% |
|
|
| 6 |
RTW INVESTMENTS, LP |
1,045,747 |
5,888,000 |
5.29% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
871,590 |
4,899,000 |
4.40% |
|
|
| 8 |
Opaleye Management Inc. |
400,000 |
2,252,000 |
2.02% |
|
|
| 9 |
VANGUARD GROUP INC |
361,228 |
2,030,000 |
1.82% |
|
|
| 10 |
PUTNAM INVESTMENTS LLC |
322,100 |
1,810,000 |
1.63% |
|
|
| 11 |
NEEDHAM INVESTMENT MANAGEMENT LLC |
287,324 |
1,617,000 |
1.45% |
|
|
| 12 |
WALL STREET ASSOCIATES |
265,700 |
1,496,000 |
1.34% |
|
|
| 13 |
AWM Investment Company, Inc. |
198,511 |
1,116,000 |
1.00% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
140,000 |
787,000 |
0.71% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
66,313 |
373,000 |
0.33% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
65,529 |
368,000 |
0.33% |
|
|
| 17 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
63,722 |
359,000 |
0.32% |
|
|
| 18 |
BlackRock Fund Advisors |
35,038 |
197,000 |
0.18% |
|
|
| 19 |
NORTHERN TRUST CORP |
18,633 |
105,000 |
0.09% |
|
|
| 20 |
PANAGORA ASSET MANAGEMENT INC |
15,642 |
88,000 |
0.08% |
|
|
| 21 |
Bank of New York Mellon Corp |
12,322 |
69,000 |
0.06% |
|
|
| 22 |
TFS CAPITAL LLC |
11,379 |
64,000 |
0.06% |
|
|
| 23 |
JPMORGAN CHASE & CO |
11,175 |
63,000 |
0.06% |
|
|
| 24 |
VICTORY CAPITAL MANAGEMENT INC |
4,351 |
24,000 |
0.02% |
|
|
| 25 |
WELLS FARGO & COMPANY/MN |
3,000 |
17,000 |
0.02% |
|
|
| 26 |
BlackRock Investment Management, LLC |
2,270 |
13,000 |
0.01% |
|
|
| 27 |
Parallax Volatility Advisers, L.P. |
1,783 |
10,000 |
0.01% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
1,440 |
8,000 |
0.01% |
|
|
| 29 |
BARCLAYS PLC |
1,500 |
8,000 |
0.01% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
1,123 |
6,000 |
0.01% |
|
|
| 31 |
CITIGROUP INC |
1,000 |
6,000 |
0.01% |
|
|
| 32 |
UBS Group AG |
907 |
5,000 |
0.00% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
912 |
5,000 |
0.00% |
|
|
| 34 |
TCI Wealth Advisors, Inc. |
162 |
1,000 |
0.00% |
|
|
