| 1 |
Essex Woodlands Management, Inc. |
9,353,304 |
75,949,000 |
46.64% |
|
|
| 2 |
Broadfin Capital, LLC |
1,802,092 |
14,633,000 |
8.99% |
|
|
| 3 |
TAMARACK ADVISERS, LP |
1,385,000 |
11,246,000 |
6.91% |
|
|
| 4 |
GOLDMAN SACHS GROUP INC |
1,372,188 |
11,142,000 |
6.84% |
|
|
| 5 |
SENZAR ASSET MANAGEMENT, LLC |
1,321,479 |
10,730,410 |
6.59% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
807,090 |
6,554,000 |
4.02% |
|
|
| 7 |
RTW INVESTMENTS, LP |
730,031 |
5,928,000 |
3.64% |
|
|
| 8 |
VANGUARD GROUP INC |
365,097 |
2,965,000 |
1.82% |
|
|
| 9 |
Opaleye Management Inc. |
355,000 |
2,883,000 |
1.77% |
|
|
| 10 |
PUTNAM INVESTMENTS LLC |
325,000 |
2,639,000 |
1.62% |
|
|
| 11 |
BlackRock Fund Advisors |
285,214 |
2,316,000 |
1.42% |
|
|
| 12 |
WALL STREET ASSOCIATES |
265,700 |
2,157,000 |
1.32% |
|
|
| 13 |
TURNER INVESTMENTS LLC |
197,520 |
1,604,000 |
0.98% |
|
|
| 14 |
AWM Investment Company, Inc. |
196,376 |
1,595,000 |
0.98% |
|
|
| 15 |
Lombard Odier Asset Management (USA) Corp |
179,760 |
1,460,000 |
0.90% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
139,846 |
1,136,000 |
0.70% |
|
|
| 17 |
Ghost Tree Capital, LLC |
125,000 |
1,015,000 |
0.62% |
|
|
| 18 |
NEEDHAM INVESTMENT MANAGEMENT LLC |
117,608 |
955,000 |
0.59% |
|
|
| 19 |
NORTHERN TRUST CORP |
108,283 |
879,000 |
0.54% |
|
|
| 20 |
EMERALD MUTUAL FUND ADVISERS TRUST |
91,873 |
746,000 |
0.46% |
|
|
| 21 |
TFS CAPITAL LLC |
78,458 |
637,000 |
0.39% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
75,684 |
614,000 |
0.38% |
|
|
| 23 |
STATE STREET CORP |
72,710 |
589,000 |
0.36% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
70,000 |
568,000 |
0.35% |
|
|
| 25 |
BlackRock Investment Management, LLC |
37,786 |
307,000 |
0.19% |
|
|
| 26 |
Bank of New York Mellon Corp |
35,719 |
290,000 |
0.18% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
30,579 |
248,000 |
0.15% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
19,721 |
160,000 |
0.10% |
|
|
| 29 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
18,400 |
149,000 |
0.09% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
15,816 |
128,000 |
0.08% |
|
|
| 31 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
12,013 |
98,000 |
0.06% |
|
|
| 32 |
MILLENNIUM MANAGEMENT LLC |
11,498 |
93,000 |
0.06% |
|
|
| 33 |
UBS Group AG |
9,297 |
75,000 |
0.05% |
|
|
| 34 |
PRELUDE CAPITAL MANAGEMENT, LLC |
8,300 |
67,000 |
0.04% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,000 |
65,000 |
0.04% |
|
|
| 36 |
Nationwide Fund Advisors |
6,142 |
50,000 |
0.03% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,089 |
41,000 |
0.03% |
|
|
| 38 |
VICTORY CAPITAL MANAGEMENT INC |
3,108 |
25,000 |
0.02% |
|
|
| 39 |
BLACKROCK ADVISORS LLC |
2,673 |
22,000 |
0.01% |
|
|
| 40 |
STRS OHIO |
2,800 |
22,000 |
0.01% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
2,648 |
21,000 |
0.01% |
|
|
| 42 |
Parallax Volatility Advisers, L.P. |
1,783 |
14,000 |
0.01% |
|
|
| 43 |
MORGAN STANLEY |
1,524 |
13,000 |
0.01% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
1,176 |
9,549 |
0.01% |
|
|
| 45 |
Tower Research Capital LLC (TRC) |
536 |
4,000 |
0.00% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
257 |
2,000 |
0.00% |
|
|
| 47 |
GLOBEFLEX CAPITAL L P |
114 |
1,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
57 |
0 |
0.00% |
|
|
