| 1 |
Essex Woodlands Management, Inc. |
9,353,304 |
37,974,000 |
47.35% |
|
|
| 2 |
Broadfin Capital, LLC |
1,919,721 |
7,794,000 |
9.72% |
|
|
| 3 |
GOLDMAN SACHS GROUP INC |
1,591,564 |
6,462,000 |
8.06% |
|
|
| 4 |
SENZAR ASSET MANAGEMENT, LLC |
1,576,766 |
6,402,000 |
7.98% |
|
|
| 5 |
RTW INVESTMENTS, LP |
1,101,045 |
4,470,000 |
5.57% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
871,590 |
3,539,000 |
4.41% |
|
|
| 7 |
TAMARACK ADVISERS, LP |
737,242 |
2,993,000 |
3.73% |
|
|
| 8 |
NEEDHAM INVESTMENT MANAGEMENT LLC |
597,824 |
2,427,000 |
3.03% |
|
|
| 9 |
Opaleye Management Inc. |
380,000 |
1,543,000 |
1.92% |
|
|
| 10 |
VANGUARD GROUP INC |
347,607 |
1,411,000 |
1.76% |
|
|
| 11 |
FMR LLC |
220,000 |
893,000 |
1.11% |
|
|
| 12 |
WALL STREET ASSOCIATES |
210,520 |
855,000 |
1.07% |
|
|
| 13 |
AWM Investment Company, Inc. |
200,000 |
812,000 |
1.01% |
|
|
| 14 |
ROYCE & ASSOCIATES LP |
177,864 |
722,000 |
0.90% |
|
|
| 15 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
101,655 |
413,000 |
0.51% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
85,000 |
345,000 |
0.43% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
69,108 |
280,000 |
0.35% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
66,313 |
269,000 |
0.34% |
|
|
| 19 |
BlackRock Fund Advisors |
35,906 |
146,000 |
0.18% |
|
|
| 20 |
PUTNAM INVESTMENTS LLC |
29,055 |
118,000 |
0.15% |
|
|
| 21 |
NORTHERN TRUST CORP |
19,304 |
78,000 |
0.10% |
|
|
| 22 |
PRELUDE CAPITAL MANAGEMENT, LLC |
17,881 |
73,000 |
0.09% |
|
|
| 23 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
12,600 |
51,000 |
0.06% |
|
|
| 24 |
Bank of New York Mellon Corp |
11,586 |
47,000 |
0.06% |
|
|
| 25 |
PANAGORA ASSET MANAGEMENT INC |
6,805 |
28,000 |
0.03% |
|
|
| 26 |
VICTORY CAPITAL MANAGEMENT INC |
4,606 |
19,000 |
0.02% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
3,000 |
12,000 |
0.01% |
|
|
| 28 |
BlackRock Investment Management, LLC |
2,270 |
9,000 |
0.01% |
|
|
| 29 |
Parallax Volatility Advisers, L.P. |
1,783 |
7,000 |
0.01% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
912 |
4,000 |
0.00% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
1,017 |
4,000 |
0.00% |
|
|
| 32 |
TCI Wealth Advisors, Inc. |
162 |
1,000 |
0.00% |
|
|
