| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 1,893,123 | 117,923,000 | 8.99% | ||
| 2 | FMR LLC | 1,718,486 | 107,044,000 | 8.16% | ||
| 3 | RS INVESTMENT MANAGEMENT CO LLC | 1,392,185 | 86,719,000 | 6.61% | ||
| 4 | BlackRock Fund Advisors | 1,298,901 | 80,909,000 | 6.17% | ||
| 5 | KNOTT DAVID M | 1,249,766 | 77,847,923 | 5.94% | ||
| 6 | VANGUARD GROUP INC | 1,043,782 | 65,017,000 | 4.96% | ||
| 7 | BLAIR WILLIAM & CO/IL | 843,711 | 52,554,000 | 4.01% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 593,089 | 36,944,000 | 2.82% | ||
| 9 | STATE STREET CORP | 571,984 | 35,632,000 | 2.72% | ||
| 10 | CARDINAL CAPITAL MANAGEMENT LLC /CT | 568,199 | 35,393,000 | 2.70% | ||
| 11 | Invesco Ltd. | 545,116 | 33,955,000 | 2.59% | ||
| 12 | DIMENSIONAL FUND ADVISORS LP | 371,438 | 23,137,000 | 1.76% | ||
| 13 | WELLS FARGO & COMPANY/MN | 328,689 | 20,474,000 | 1.56% | ||
| 14 | Stephens Investment Management Group LLC | 324,299 | 20,201,000 | 1.54% | ||
| 15 | TAMRO Capital Partners LLC | 302,220 | 18,825,000 | 1.44% | ||
| 16 | Allianz Asset Management GmbH | 277,963 | 17,314,000 | 1.32% | ||
| 17 | COLUMBUS CIRCLE INVESTORS | 260,157 | 16,205,000 | 1.24% | ||
| 18 | NEXT CENTURY GROWTH INVESTORS LLC | 257,849 | 16,061,000 | 1.22% | ||
| 19 | NORTHERN TRUST CORP | 250,819 | 15,624,000 | 1.19% | ||
| 20 | Conestoga Capital Advisors, LLC | 243,967 | 15,197,000 | 1.16% | ||
| 21 | PRUDENTIAL FINANCIAL INC | 241,076 | 15,017,000 | 1.15% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 222,341 | 13,850,000 | 1.06% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 215,879 | 13,447,000 | 1.03% | ||
| 24 | ARBOR CAPITAL MANAGEMENT LLC | 211,665 | 13,185,000 | 1.01% | ||
| 25 | Bank of New York Mellon Corp | 204,484 | 12,738,000 | 0.97% | ||
| 26 | GOLDMAN SACHS GROUP INC | 201,322 | 12,540,000 | 0.96% | ||
| 27 | TEACHERS ADVISORS, LLC | 193,660 | 12,063,000 | 0.92% | ||
| 28 | OBERWEIS ASSET MANAGEMENT INC/ | 176,837 | 11,015,000 | 0.84% | ||
| 29 | RUSSELL FRANK CO/ | 219,635 | 10,816,000 | 0.82% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 152,730 | 9,514,000 | 0.73% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 149,700 | 9,325,000 | 0.71% | ||
| 32 | AMERIPRISE FINANCIAL INC | 146,478 | 9,124,000 | 0.70% | ||
| 33 | OXFORD ASSET MANAGEMENT LLP | 143,233 | 8,849,000 | 0.67% | ||
| 34 | ASHFORD CAPITAL MANAGEMENT INC | 141,471 | 8,812,000 | 0.67% | ||
| 35 | PRINCIPAL FINANCIAL GROUP INC | 130,479 | 8,127,000 | 0.62% | ||
| 36 | Nichols Asset Management LLC | 130,384 | 8,122,000 | 0.62% | ||
| 37 | GROW Partners, LLC | 127,200 | 7,923,000 | 0.60% | ||
| 38 | CREDIT SUISSE AG/ | 125,457 | 7,815,000 | 0.60% | ||
| 39 | RK Capital Management, LLC | 124,334 | 7,745,000 | 0.59% | ||
| 40 | EAGLE ASSET MANAGEMENT INC | 123,706 | 7,705,000 | 0.59% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 115,269 | 7,179,000 | 0.55% | ||
| 42 | Timpani Capital Management LLC | 110,306 | 6,871,000 | 0.52% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,300 | 6,684,000 | 0.51% | Put | |
| 44 | CASTLEARK MANAGEMENT LLC | 101,266 | 6,308,000 | 0.48% | ||
| 45 | PRICE T ROWE ASSOCIATES INC /MD/ | 91,038 | 5,671,000 | 0.43% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 89,122 | 5,552,000 | 0.42% | ||
| 47 | DEUTSCHE BANK AG\ | 86,199 | 5,368,000 | 0.41% | ||
| 48 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 86,100 | 5,363,000 | 0.41% | ||
| 49 | First Light Asset Management, LLC | 74,363 | 4,632,000 | 0.35% | ||
| 50 | BAKER BROS. ADVISORS LP | 73,400 | 4,572,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
