| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,096,416 | 141,005,000 | 9.82% | ||
| 2 | FMR LLC | 1,664,786 | 111,974,000 | 7.80% | ||
| 3 | BlackRock Fund Advisors | 1,355,000 | 91,151,000 | 6.35% | ||
| 4 | KNOTT DAVID M | 1,249,766 | 84,071,759 | 5.85% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 1,222,507 | 82,226,000 | 5.73% | ||
| 6 | VANGUARD GROUP INC | 984,239 | 66,200,000 | 4.61% | ||
| 7 | BLAIR WILLIAM & CO/IL | 936,671 | 63,010,000 | 4.39% | ||
| 8 | Invesco Ltd. | 641,797 | 43,173,000 | 3.01% | ||
| 9 | STATE STREET CORP | 589,471 | 39,646,000 | 2.76% | ||
| 10 | CARDINAL CAPITAL MANAGEMENT LLC /CT | 587,214 | 39,502,000 | 2.75% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 571,286 | 38,430,000 | 2.68% | ||
| 12 | NEXT CENTURY GROWTH INVESTORS LLC | 411,956 | 27,708,000 | 1.93% | ||
| 13 | NORTHERN TRUST CORP | 368,689 | 24,801,000 | 1.73% | ||
| 14 | TAMRO Capital Partners LLC | 311,507 | 20,955,000 | 1.46% | ||
| 15 | ARBOR CAPITAL MANAGEMENT LLC | 296,095 | 19,918,000 | 1.39% | ||
| 16 | Stephens Investment Management Group LLC | 288,929 | 19,433,000 | 1.35% | ||
| 17 | COLUMBUS CIRCLE INVESTORS | 288,457 | 19,405,000 | 1.35% | ||
| 18 | WELLS FARGO & COMPANY/MN | 287,997 | 19,374,000 | 1.35% | ||
| 19 | Allianz Asset Management GmbH | 279,831 | 18,684,000 | 1.30% | ||
| 20 | PANAGORA ASSET MANAGEMENT INC | 272,172 | 18,306,000 | 1.27% | ||
| 21 | GILDER GAGNON HOWE & CO LLC | 256,909 | 17,282,000 | 1.20% | ||
| 22 | CASTLEARK MANAGEMENT LLC | 236,646 | 15,919,000 | 1.11% | ||
| 23 | PRUDENTIAL FINANCIAL INC | 231,262 | 15,555,000 | 1.08% | ||
| 24 | DIMENSIONAL FUND ADVISORS LP | 220,968 | 14,863,000 | 1.03% | ||
| 25 | OBERWEIS ASSET MANAGEMENT INC/ | 213,737 | 14,378,000 | 1.00% | ||
| 26 | Bank of New York Mellon Corp | 197,842 | 13,309,000 | 0.93% | ||
| 27 | RUSSELL FRANK CO/ | 187,814 | 12,633,000 | 0.88% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 180,360 | 12,131,000 | 0.84% | ||
| 29 | BARCLAYS PLC | 169,800 | 11,377,000 | 0.79% | Call | |
| 30 | TEACHERS ADVISORS, LLC | 156,537 | 10,529,000 | 0.73% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 147,900 | 9,948,000 | 0.69% | ||
| 32 | ASHFORD CAPITAL MANAGEMENT INC | 145,641 | 9,797,000 | 0.68% | ||
| 33 | OXFORD ASSET MANAGEMENT LLP | 142,000 | 9,551,000 | 0.67% | ||
| 34 | DRIEHAUS CAPITAL MANAGEMENT LLC | 135,254 | 9,097,000 | 0.63% | ||
| 35 | PRINCIPAL FINANCIAL GROUP INC | 130,474 | 8,776,000 | 0.61% | ||
| 36 | GOLDMAN SACHS GROUP INC | 126,883 | 8,536,000 | 0.59% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 124,185 | 8,352,000 | 0.58% | ||
| 38 | BARCLAYS PLC | 123,400 | 8,268,000 | 0.58% | Put | |
| 39 | EAGLE ASSET MANAGEMENT INC | 121,178 | 8,151,000 | 0.57% | ||
| 40 | AMERIPRISE FINANCIAL INC | 117,611 | 7,910,000 | 0.55% | ||
| 41 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 106,716 | 7,178,000 | 0.50% | ||
| 42 | CREDIT SUISSE AG/ | 99,958 | 6,724,000 | 0.47% | ||
| 43 | RK Capital Management, LLC | 96,834 | 6,514,000 | 0.45% | ||
| 44 | Timpani Capital Management LLC | 95,353 | 6,414,000 | 0.45% | ||
| 45 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 93,900 | 6,316,000 | 0.44% | ||
| 46 | GROW Partners, LLC | 82,300 | 5,535,000 | 0.39% | ||
| 47 | PRICE T ROWE ASSOCIATES INC /MD/ | 81,038 | 5,451,000 | 0.38% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 75,328 | 5,067,000 | 0.35% | ||
| 49 | BAKER BROS. ADVISORS LP | 73,400 | 4,937,000 | 0.34% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,900 | 4,769,000 | 0.33% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
