| 1 |
FMR LLC |
1,959,742 |
54,539,000 |
13.72% |
|
|
| 2 |
TPG Group Holdings (SBS) Advisors, Inc. |
1,870,332 |
52,051,000 |
13.09% |
|
|
| 3 |
MPM ASSET MANAGEMENT LLC |
1,780,955 |
49,564,000 |
12.47% |
|
|
| 4 |
CAISSE DE DEPOT ET PLACEMENT DU QUEBEC |
1,112,086 |
30,949,000 |
7.78% |
|
|
| 5 |
Blue Ridge Capital, L.L.C. |
900,000 |
25,047,000 |
6.30% |
|
|
| 6 |
SAC Capital Advisors LP |
870,189 |
24,217,000 |
6.09% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
491,897 |
13,689,000 |
3.44% |
|
|
| 8 |
FRANKLIN RESOURCES INC |
466,400 |
12,980,000 |
3.26% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
448,945 |
12,494,000 |
3.14% |
|
|
| 10 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
380,701 |
10,595,000 |
2.66% |
|
|
| 11 |
PointState Capital LP |
375,000 |
10,436,000 |
2.62% |
|
|
| 12 |
CHARTWELL INVESTMENT PARTNERS/PA |
245,210 |
6,824,000 |
1.72% |
|
|
| 13 |
VANGUARD GROUP INC |
242,084 |
6,737,000 |
1.69% |
|
|
| 14 |
JPMORGAN CHASE & CO |
241,550 |
6,723,000 |
1.69% |
|
|
| 15 |
EMERALD ADVISERS, LLC |
226,919 |
6,315,000 |
1.59% |
|
|
| 16 |
PFM Health Sciences, LP |
209,212 |
5,822,000 |
1.46% |
|
|
| 17 |
EMERALD MUTUAL FUND ADVISERS TRUST |
200,877 |
5,590,000 |
1.41% |
|
|
| 18 |
RA CAPITAL MANAGEMENT, L.P. |
199,398 |
5,549,000 |
1.40% |
|
|
| 19 |
BlackRock Fund Advisors |
174,758 |
4,864,000 |
1.22% |
|
|
| 20 |
SABBY MANAGEMENT, LLC |
150,553 |
4,190,000 |
1.05% |
|
|
| 21 |
FEDERATED HERMES, INC. |
114,600 |
3,189,000 |
0.80% |
|
|
| 22 |
CITADEL ADVISORS LLC |
100,319 |
2,792,000 |
0.70% |
|
|
| 23 |
JENNISON ASSOCIATES LLC |
98,940 |
2,754,000 |
0.69% |
|
|
| 24 |
BAKER BROS. ADVISORS LP |
96,165 |
2,676,000 |
0.67% |
|
|
| 25 |
STATE STREET CORP |
95,749 |
2,665,000 |
0.67% |
|
|
| 26 |
BLACKROCK ADVISORS LLC |
90,757 |
2,526,000 |
0.64% |
|
|
| 27 |
NORTHERN TRUST CORP |
77,584 |
2,159,000 |
0.54% |
|
|
| 28 |
PRINCIPAL FINANCIAL GROUP INC |
75,800 |
2,110,000 |
0.53% |
|
|
| 29 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
61,426 |
1,709,000 |
0.43% |
|
|
| 30 |
Alyeska Investment Group, L.P. |
61,250 |
1,705,000 |
0.43% |
|
|
| 31 |
BlackRock Institutional Trust Company, N.A. |
61,181 |
1,703,000 |
0.43% |
|
|
| 32 |
EVENTIDE ASSET MANAGEMENT, LLC |
56,200 |
1,564,000 |
0.39% |
|
|
| 33 |
MILLENNIUM MANAGEMENT LLC |
50,555 |
1,407,000 |
0.35% |
|
|
| 34 |
GEODE CAPITAL MANAGEMENT, LLC |
50,416 |
1,403,000 |
0.35% |
|
|
| 35 |
SIGMA CAPITAL MANAGEMENT LLC |
50,000 |
1,392,000 |
0.35% |
|
|
| 36 |
SPHERA FUNDS MANAGEMENT LTD. |
41,000 |
1,141,000 |
0.29% |
|
|
| 37 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
39,200 |
1,091,000 |
0.27% |
|
|
| 38 |
Informed Momentum Co LLC |
32,451 |
903,000 |
0.23% |
|
|
| 39 |
FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ |
31,404 |
874,000 |
0.22% |
|
|
| 40 |
Opaleye Management Inc. |
30,000 |
838,000 |
0.21% |
|
|
| 41 |
Absolute Return Capital, LLC |
29,692 |
826,000 |
0.21% |
|
|
| 42 |
Tekla Capital Management LLC |
31,857 |
798,000 |
0.20% |
|
|
| 43 |
Bank of New York Mellon Corp |
27,404 |
763,000 |
0.19% |
|
|
| 44 |
BlackRock Group LTD |
26,300 |
732,000 |
0.18% |
|
|
| 45 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
23,471 |
653,000 |
0.16% |
|
|
| 46 |
Calamos Advisors LLC |
22,850 |
636,000 |
0.16% |
|
|
| 47 |
PANAGORA ASSET MANAGEMENT INC |
22,207 |
618,000 |
0.16% |
|
|
| 48 |
Aldebaran Financial Inc. |
21,000 |
584,000 |
0.15% |
|
|
| 49 |
Rhenman & Partners Asset Management AB |
20,000 |
557,000 |
0.14% |
|
|
| 50 |
BlackRock Investment Management, LLC |
17,901 |
498,000 |
0.13% |
|
|
