| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,225,358 | 106,806,000 | 17.97% | ||
| 2 | OppenheimerFunds, Inc. | 3,037,007 | 62,076,000 | 10.44% | ||
| 3 | BB BIOTECH AG | 1,920,000 | 39,245,000 | 6.60% | ||
| 4 | BlackRock Fund Advisors | 1,510,142 | 30,867,000 | 5.19% | ||
| 5 | Blue Ridge Capital, L.L.C. | 1,360,000 | 27,798,000 | 4.68% | ||
| 6 | VANGUARD GROUP INC | 1,308,184 | 26,740,000 | 4.50% | ||
| 7 | Point72 Asset Management, L.P. | 1,213,117 | 24,796,000 | 4.17% | ||
| 8 | INTERWEST VENTURE MANAGEMENT CO | 1,074,316 | 21,959,000 | 3.69% | ||
| 9 | STATE STREET CORP | 839,491 | 17,152,000 | 2.89% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 814,004 | 16,638,000 | 2.80% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 725,800 | 14,835,000 | 2.50% | ||
| 12 | PINNACLE ASSOCIATES LTD | 652,777 | 13,343,000 | 2.24% | ||
| 13 | FRANKLIN RESOURCES INC | 587,100 | 12,000,000 | 2.02% | ||
| 14 | EMERALD ADVISERS, LLC | 482,835 | 9,869,000 | 1.66% | ||
| 15 | Hood River Capital Management LLC | 480,452 | 9,820,000 | 1.65% | ||
| 16 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 433,854 | 8,869,000 | 1.49% | ||
| 17 | Spark Investment Management LLC | 415,300 | 8,488,000 | 1.43% | ||
| 18 | NORTHERN TRUST CORP | 382,793 | 7,825,000 | 1.32% | ||
| 19 | BAKER BROS. ADVISORS LP | 363,676 | 7,434,000 | 1.25% | ||
| 20 | EMERALD MUTUAL FUND ADVISERS TRUST | 358,161 | 7,321,000 | 1.23% | ||
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 336,697 | 6,882,000 | 1.16% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 249,687 | 5,103,000 | 0.86% | ||
| 23 | TEACHERS ADVISORS, LLC | 246,173 | 5,032,000 | 0.85% | ||
| 24 | TIGER MANAGEMENT L.L.C. | 239,667 | 4,899,000 | 0.82% | ||
| 25 | Rock Springs Capital Management LP | 225,000 | 4,599,000 | 0.77% | ||
| 26 | Artal Group S.A. | 200,000 | 4,088,000 | 0.69% | ||
| 27 | FEDERATED HERMES, INC. | 190,892 | 3,902,000 | 0.66% | ||
| 28 | JENNISON ASSOCIATES LLC | 188,908 | 3,861,000 | 0.65% | ||
| 29 | MARSHALL WACE, LLP | 181,267 | 3,705,000 | 0.62% | ||
| 30 | First Eagle Investment Management, LLC | 175,000 | 3,577,000 | 0.60% | ||
| 31 | Opaleye Management Inc. | 170,000 | 3,475,000 | 0.58% | ||
| 32 | Rhenman & Partners Asset Management AB | 155,000 | 3,168,000 | 0.53% | ||
| 33 | Bank of New York Mellon Corp | 138,552 | 2,832,000 | 0.48% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 126,235 | 2,580,000 | 0.43% | ||
| 35 | BlackRock Investment Management, LLC | 124,466 | 2,544,000 | 0.43% | ||
| 36 | CITADEL ADVISORS LLC | 121,278 | 2,479,000 | 0.42% | ||
| 37 | PRINCIPAL FINANCIAL GROUP INC | 115,042 | 2,351,000 | 0.40% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,861 | 2,348,000 | 0.39% | ||
| 39 | JPMORGAN CHASE & CO | 98,600 | 2,015,000 | 0.34% | ||
| 40 | MORGAN STANLEY | 94,697 | 1,936,000 | 0.33% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 90,541 | 1,851,000 | 0.31% | ||
| 42 | DAFNA Capital Management LLC | 89,200 | 1,823,000 | 0.31% | ||
| 43 | BELLEVUE GROUP AG | 83,000 | 1,697,000 | 0.29% | ||
| 44 | SPHERA FUNDS MANAGEMENT LTD. | 81,200 | 1,660,000 | 0.28% | ||
| 45 | Numeric Investors LLC | 76,465 | 1,563,000 | 0.26% | ||
| 46 | TFS CAPITAL LLC | 74,801 | 1,529,000 | 0.26% | ||
| 47 | CITIGROUP INC | 70,498 | 1,441,000 | 0.24% | ||
| 48 | Allianz Asset Management GmbH | 67,337 | 1,376,000 | 0.23% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,749 | 1,344,000 | 0.23% | ||
| 50 | First Light Asset Management, LLC | 61,835 | 1,264,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
