| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,975,827 | 148,827,000 | 17.56% | ||
| 2 | OppenheimerFunds, Inc. | 3,000,820 | 89,755,000 | 10.59% | ||
| 3 | Point72 Asset Management, L.P. | 1,813,300 | 54,236,000 | 6.40% | ||
| 4 | BB BIOTECH AG | 1,455,000 | 43,519,000 | 5.14% | ||
| 5 | Blue Ridge Capital, L.L.C. | 1,360,000 | 40,678,000 | 4.80% | ||
| 6 | BlackRock Fund Advisors | 1,344,292 | 40,208,000 | 4.74% | ||
| 7 | VANGUARD GROUP INC | 1,298,159 | 38,828,000 | 4.58% | ||
| 8 | STATE STREET CORP | 830,830 | 24,852,000 | 2.93% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 750,344 | 22,443,000 | 2.65% | ||
| 10 | EVENTIDE ASSET MANAGEMENT, LLC | 725,800 | 21,709,000 | 2.56% | ||
| 11 | Cormorant Asset Management, LP | 707,978 | 21,176,000 | 2.50% | ||
| 12 | PINNACLE ASSOCIATES LTD | 698,140 | 20,881,000 | 2.46% | ||
| 13 | FRANKLIN RESOURCES INC | 598,800 | 17,910,000 | 2.11% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 525,671 | 15,722,000 | 1.86% | ||
| 15 | EMERALD ADVISERS, LLC | 409,942 | 12,261,000 | 1.45% | ||
| 16 | Spark Investment Management LLC | 390,600 | 11,682,000 | 1.38% | ||
| 17 | NORTHERN TRUST CORP | 379,536 | 11,351,000 | 1.34% | ||
| 18 | BAKER BROS. ADVISORS LP | 363,676 | 10,878,000 | 1.28% | ||
| 19 | EMERALD MUTUAL FUND ADVISERS TRUST | 358,161 | 10,713,000 | 1.26% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 341,709 | 10,221,000 | 1.21% | ||
| 21 | EverPoint Asset Management, LLC | 300,000 | 8,973,000 | 1.06% | ||
| 22 | TIGER MANAGEMENT L.L.C. | 266,067 | 7,958,000 | 0.94% | ||
| 23 | FEDERATED HERMES, INC. | 257,976 | 7,716,000 | 0.91% | ||
| 24 | TEACHERS ADVISORS, LLC | 243,632 | 7,287,000 | 0.86% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 225,141 | 6,733,000 | 0.79% | ||
| 26 | Rock Springs Capital Management LP | 225,000 | 6,730,000 | 0.79% | ||
| 27 | First Eagle Investment Management, LLC | 221,800 | 6,634,000 | 0.78% | ||
| 28 | JENNISON ASSOCIATES LLC | 195,111 | 5,836,000 | 0.69% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 190,552 | 5,699,000 | 0.67% | ||
| 30 | Hood River Capital Management LLC | 189,174 | 5,658,000 | 0.67% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 180,000 | 5,384,000 | 0.64% | ||
| 32 | Artal Group S.A. | 150,000 | 4,487,000 | 0.53% | ||
| 33 | Opaleye Management Inc. | 145,000 | 4,337,000 | 0.51% | ||
| 34 | Rhenman & Partners Asset Management AB | 140,000 | 4,187,400 | 0.49% | ||
| 35 | Bank of New York Mellon Corp | 131,543 | 3,934,000 | 0.46% | ||
| 36 | SPHERA FUNDS MANAGEMENT LTD. | 130,000 | 3,888,000 | 0.46% | ||
| 37 | BlackRock Investment Management, LLC | 124,896 | 3,736,000 | 0.44% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,515 | 3,605,000 | 0.43% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 114,385 | 3,421,000 | 0.40% | ||
| 40 | Allianz Asset Management GmbH | 112,678 | 3,370,000 | 0.40% | ||
| 41 | Candriam S.C.A. | 110,000 | 3,290,000 | 0.39% | ||
| 42 | JPMORGAN CHASE & CO | 105,227 | 3,147,000 | 0.37% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,527 | 2,977,000 | 0.35% | ||
| 44 | MARSHALL WACE, LLP | 95,716 | 2,863,000 | 0.34% | ||
| 45 | BELLEVUE GROUP AG | 83,000 | 2,483,000 | 0.29% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 76,288 | 2,282,000 | 0.27% | ||
| 47 | Private Capital Advisors, Inc. | 72,500 | 2,168,000 | 0.26% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,449 | 2,017,000 | 0.24% | ||
| 49 | Numeric Investors LLC | 58,865 | 1,761,000 | 0.21% | ||
| 50 | SUFFOLK CAPITAL MANAGEMENT LLC | 54,717 | 1,637,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
