| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 2,194,841 | 84,875,000 | 18.73% | ||
| 2 | NEA Management Company, LLC | 1,369,899 | 52,974,000 | 11.69% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,047,093 | 40,491,000 | 8.93% | ||
| 4 | FMR LLC | 893,500 | 34,552,000 | 7.62% | ||
| 5 | MPM ASSET MANAGEMENT LLC | 686,704 | 26,555,000 | 5.86% | ||
| 6 | FRANKLIN RESOURCES INC | 580,623 | 22,453,000 | 4.95% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 385,168 | 14,894,000 | 3.29% | ||
| 8 | JPMORGAN CHASE & CO | 363,234 | 14,045,000 | 3.10% | ||
| 9 | VANGUARD GROUP INC | 351,452 | 13,590,000 | 3.00% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 349,200 | 13,504,000 | 2.98% | ||
| 11 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 296,454 | 11,463,876 | 2.53% | ||
| 12 | Redmile Group, LLC | 234,254 | 9,059,000 | 2.00% | ||
| 13 | BlackRock Fund Advisors | 220,921 | 8,543,000 | 1.88% | ||
| 14 | SENZAR ASSET MANAGEMENT, LLC | 212,503 | 8,217,000 | 1.81% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 180,417 | 6,977,000 | 1.54% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 179,077 | 6,925,000 | 1.53% | ||
| 17 | Pier Capital, LLC | 178,864 | 6,917,000 | 1.53% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 176,563 | 6,828,000 | 1.51% | ||
| 19 | FRED ALGER MANAGEMENT, LLC | 176,239 | 6,815,000 | 1.50% | ||
| 20 | JENNISON ASSOCIATES LLC | 146,875 | 5,680,000 | 1.25% | ||
| 21 | KORNITZER CAPITAL MANAGEMENT INC /KS | 132,355 | 5,118,000 | 1.13% | ||
| 22 | BLACKROCK ADVISORS LLC | 116,457 | 4,503,000 | 0.99% | ||
| 23 | Ghost Tree Capital, LLC | 115,000 | 4,447,000 | 0.98% | ||
| 24 | Visium Asset Management, LP | 100,000 | 3,867,000 | 0.85% | ||
| 25 | MORGAN STANLEY | 96,128 | 3,717,000 | 0.82% | ||
| 26 | NORTHERN TRUST CORP | 78,893 | 3,051,000 | 0.67% | ||
| 27 | LORD, ABBETT & CO. LLC | 75,251 | 2,910,000 | 0.64% | ||
| 28 | BlackRock Group LTD | 70,742 | 2,735,000 | 0.60% | ||
| 29 | FEDERATED HERMES, INC. | 68,500 | 2,649,000 | 0.58% | ||
| 30 | STATE STREET CORP | 66,088 | 2,557,000 | 0.56% | ||
| 31 | PURA VIDA INVESTMENTS, LLC | 56,900 | 2,200,000 | 0.49% | ||
| 32 | Dorsey & Whitney Trust CO LLC | 38,489 | 1,488,000 | 0.33% | ||
| 33 | BlackRock Investment Management, LLC | 38,201 | 1,477,000 | 0.33% | ||
| 34 | RUSSELL FRANK CO/ | 30,743 | 1,184,000 | 0.26% | ||
| 35 | Bank of New York Mellon Corp | 29,193 | 1,129,000 | 0.25% | ||
| 36 | Informed Momentum Co LLC | 29,164 | 1,128,000 | 0.25% | ||
| 37 | MARSHALL WACE, LLP | 26,502 | 1,025,000 | 0.23% | ||
| 38 | ArrowMark Colorado Holdings LLC | 25,528 | 987,000 | 0.22% | ||
| 39 | GILDER GAGNON HOWE & CO LLC | 25,508 | 986,000 | 0.22% | ||
| 40 | Geduld E E | 21,000 | 812,000 | 0.18% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 17,552 | 678,000 | 0.15% | ||
| 42 | OPPENHEIMER & CO INC | 16,948 | 656,000 | 0.14% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,838 | 652,000 | 0.14% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 16,661 | 644,000 | 0.14% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,946 | 617,000 | 0.14% | ||
| 46 | RTW INVESTMENTS, LP | 15,356 | 594,000 | 0.13% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,000 | 580,000 | 0.13% | ||
| 48 | Calamos Advisors LLC | 13,026 | 504,000 | 0.11% | ||
| 49 | TCW GROUP INC | 11,121 | 430,000 | 0.09% | ||
| 50 | Cormorant Asset Management, LP | 10,000 | 387,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
