| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 2,194,841 | 105,199,000 | 18.32% | ||
| 2 | NEA Management Company, LLC | 1,369,899 | 65,659,000 | 11.43% | ||
| 3 | FMR LLC | 886,200 | 42,476,000 | 7.40% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 686,704 | 32,914,000 | 5.73% | ||
| 5 | COLUMBUS CIRCLE INVESTORS | 613,007 | 29,381,000 | 5.12% | ||
| 6 | FRANKLIN RESOURCES INC | 611,199 | 29,295,000 | 5.10% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 557,056 | 26,700,000 | 4.65% | ||
| 8 | SENZAR ASSET MANAGEMENT, LLC | 523,736 | 25,103,000 | 4.37% | ||
| 9 | JPMORGAN CHASE & CO | 437,437 | 20,966,000 | 3.65% | ||
| 10 | VANGUARD GROUP INC | 432,135 | 20,712,000 | 3.61% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 417,806 | 20,025,000 | 3.49% | ||
| 12 | BlackRock Fund Advisors | 223,835 | 10,728,000 | 1.87% | ||
| 13 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 209,201 | 10,027,004 | 1.75% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 202,536 | 9,708,000 | 1.69% | ||
| 15 | Cupps Capital Management, LLC | 189,543 | 9,084,000 | 1.58% | ||
| 16 | Pier Capital, LLC | 165,512 | 7,933,000 | 1.38% | ||
| 17 | LORD, ABBETT & CO. LLC | 161,102 | 7,722,000 | 1.34% | ||
| 18 | FRED ALGER MANAGEMENT, LLC | 156,811 | 7,516,000 | 1.31% | ||
| 19 | JENNISON ASSOCIATES LLC | 144,946 | 6,947,000 | 1.21% | ||
| 20 | KORNITZER CAPITAL MANAGEMENT INC /KS | 132,355 | 6,344,000 | 1.10% | ||
| 21 | LAZARD ASSET MANAGEMENT LLC | 129,425 | 6,203,000 | 1.08% | ||
| 22 | OAK RIDGE INVESTMENTS LLC | 127,038 | 6,089,000 | 1.06% | ||
| 23 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 120,417 | 5,772,000 | 1.00% | ||
| 24 | Informed Momentum Co LLC | 101,739 | 4,876,000 | 0.85% | ||
| 25 | Visium Asset Management, LP | 99,597 | 4,774,000 | 0.83% | ||
| 26 | STATE STREET CORP | 99,358 | 4,765,000 | 0.83% | ||
| 27 | NORTHERN TRUST CORP | 94,345 | 4,522,000 | 0.79% | ||
| 28 | Bank of New York Mellon Corp | 71,816 | 3,442,000 | 0.60% | ||
| 29 | MORGAN STANLEY | 62,279 | 2,985,000 | 0.52% | ||
| 30 | Forward Management, LLC | 62,274 | 2,845,000 | 0.50% | ||
| 31 | Granite Point Capital Management, L.P. | 56,400 | 2,703,000 | 0.47% | ||
| 32 | RUSSELL FRANK CO/ | 53,456 | 2,562,000 | 0.45% | ||
| 33 | FEDERATED HERMES, INC. | 49,800 | 2,387,000 | 0.42% | ||
| 34 | MARSHALL WACE, LLP | 49,194 | 2,358,000 | 0.41% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 45,363 | 2,174,000 | 0.38% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 44,605 | 2,138,000 | 0.37% | ||
| 37 | Dorsey & Whitney Trust CO LLC | 38,486 | 1,845,000 | 0.32% | ||
| 38 | BLACKROCK ADVISORS LLC | 35,900 | 1,721,000 | 0.30% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 29,719 | 1,424,000 | 0.25% | ||
| 40 | ArrowMark Colorado Holdings LLC | 29,333 | 1,406,000 | 0.24% | ||
| 41 | AMERIPRISE FINANCIAL INC | 24,216 | 1,161,000 | 0.20% | ||
| 42 | BlackRock Investment Management, LLC | 24,022 | 1,151,000 | 0.20% | ||
| 43 | GILDER GAGNON HOWE & CO LLC | 23,404 | 1,122,000 | 0.20% | ||
| 44 | Geduld E E | 21,000 | 1,007,000 | 0.18% | ||
| 45 | PDT Partners, LLC | 18,203 | 872,000 | 0.15% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,650 | 846,000 | 0.15% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,700 | 705,000 | 0.12% | ||
| 48 | CITADEL ADVISORS LLC | 14,206 | 681,000 | 0.12% | ||
| 49 | TEACHERS ADVISORS, LLC | 11,663 | 559,000 | 0.10% | ||
| 50 | A.R.T. Advisors, LLC | 11,463 | 548,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
