| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 805,691 | 15,792,000 | 14.24% | ||
| 2 | JENNISON ASSOCIATES LLC | 757,386 | 14,594,000 | 13.16% | ||
| 3 | FMR LLC | 612,396 | 12,003,000 | 10.82% | ||
| 4 | AMERIPRISE FINANCIAL INC | 481,346 | 9,435,000 | 8.51% | ||
| 5 | Capital World Investors | 343,250 | 6,728,000 | 6.07% | ||
| 6 | PRIMECAP MANAGEMENT CO/CA/ | 320,200 | 6,276,000 | 5.66% | ||
| 7 | FRANKLIN RESOURCES INC | 300,000 | 5,880,000 | 5.30% | ||
| 8 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 257,191 | 5,040,943 | 4.55% | ||
| 9 | Tekla Capital Management LLC | 232,600 | 4,559,000 | 4.11% | ||
| 10 | LAZARD ASSET MANAGEMENT LLC | 180,750 | 3,542,000 | 3.19% | ||
| 11 | VANGUARD GROUP INC | 151,363 | 2,966,000 | 2.67% | ||
| 12 | Visium Asset Management, LP | 150,000 | 2,940,000 | 2.65% | ||
| 13 | BlackRock Fund Advisors | 148,153 | 2,904,000 | 2.62% | ||
| 14 | JPMORGAN CHASE & CO | 144,525 | 2,833,000 | 2.55% | ||
| 15 | DEUTSCHE BANK AG\ | 100,008 | 1,960,000 | 1.77% | ||
| 16 | Lombard Odier Asset Management (USA) Corp | 93,900 | 1,840,000 | 1.66% | ||
| 17 | ACUTA CAPITAL PARTNERS, LLC | 90,000 | 1,764,000 | 1.59% | ||
| 18 | PRINCIPAL FINANCIAL GROUP INC | 70,000 | 1,371,000 | 1.24% | ||
| 19 | Nicholas Investment Partners, LP | 61,377 | 1,203,000 | 1.08% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 41,729 | 818,000 | 0.74% | ||
| 21 | WALL STREET ASSOCIATES | 40,000 | 784,000 | 0.71% | ||
| 22 | SOROS FUND MANAGEMENT LLC | 30,000 | 588,000 | 0.53% | ||
| 23 | D. E. Shaw & Co., Inc. | 29,901 | 586,000 | 0.53% | ||
| 24 | Bank of New York Mellon Corp | 28,401 | 557,000 | 0.50% | ||
| 25 | AWM Investment Company, Inc. | 25,000 | 490,000 | 0.44% | ||
| 26 | Spark Investment Management LLC | 22,000 | 439,000 | 0.40% | ||
| 27 | CREDIT SUISSE AG/ | 17,826 | 349,000 | 0.31% | ||
| 28 | PUTNAM INVESTMENTS LLC | 17,241 | 338,000 | 0.30% | ||
| 29 | BlackRock Investment Management, LLC | 15,555 | 305,000 | 0.28% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,617 | 267,000 | 0.24% | ||
| 31 | NORTHERN TRUST CORP | 13,279 | 260,000 | 0.23% | ||
| 32 | STATE STREET CORP | 12,832 | 252,000 | 0.23% | ||
| 33 | PANAGORA ASSET MANAGEMENT INC | 11,858 | 232,000 | 0.21% | ||
| 34 | Abingworth LLP | 10,000 | 200,000 | 0.18% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,900 | 194,000 | 0.17% | ||
| 36 | MORGAN STANLEY | 6,920 | 136,000 | 0.12% | ||
| 37 | TEACHERS ADVISORS, LLC | 5,228 | 102,000 | 0.09% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 3,776 | 74,000 | 0.07% | ||
| 39 | BLACKROCK ADVISORS LLC | 2,362 | 46,000 | 0.04% | ||
| 40 | ROYCE & ASSOCIATES LP | 2,200 | 43,000 | 0.04% | ||
| 41 | STRS OHIO | 1,800 | 35,000 | 0.03% | ||
| 42 | Tower Research Capital LLC (TRC) | 1,556 | 30,000 | 0.03% | ||
| 43 | Nationwide Fund Advisors | 1,347 | 26,000 | 0.02% | ||
| 44 | UBS Group AG | 1,233 | 24,000 | 0.02% | ||
| 45 | CITIGROUP INC | 1,084 | 21,000 | 0.02% | ||
| 46 | PNC FINANCIAL SERVICES GROUP, INC. | 1,000 | 20,000 | 0.02% | ||
| 47 | Cowen Prime Services LLC | 1,000 | 20,000 | 0.02% | ||
| 48 | MANAGED ACCOUNT ADVISORS LLC | 639 | 12,000 | 0.01% | ||
| 49 | THOMPSON DAVIS & CO., INC. | 500 | 10,000 | 0.01% | ||
| 50 | MAGEE THOMSON INVESTMENT PARTNERS LLC | 325 | 6,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
