| 1 |
EcoR1 Capital, LLC |
933,691 |
11,214,000 |
15.28% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
656,651 |
7,886,000 |
10.74% |
|
|
| 3 |
FMR LLC |
612,396 |
7,355,000 |
10.02% |
|
|
| 4 |
AMERIPRISE FINANCIAL INC |
602,997 |
7,242,000 |
9.87% |
|
|
| 5 |
Capital World Investors |
517,750 |
6,218,000 |
8.47% |
|
|
| 6 |
PRIMECAP MANAGEMENT CO/CA/ |
369,400 |
4,436,000 |
6.04% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
356,100 |
4,277,000 |
5.83% |
|
|
| 8 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
252,986 |
3,038,000 |
4.14% |
|
|
| 9 |
Tekla Capital Management LLC |
232,600 |
2,794,000 |
3.81% |
|
|
| 10 |
LAZARD ASSET MANAGEMENT LLC |
180,750 |
2,170,000 |
2.96% |
|
|
| 11 |
VANGUARD GROUP INC |
177,001 |
2,126,000 |
2.90% |
|
|
| 12 |
BlackRock Fund Advisors |
145,363 |
1,746,000 |
2.38% |
|
|
| 13 |
JPMORGAN CHASE & CO |
136,675 |
1,641,000 |
2.24% |
|
|
| 14 |
Lombard Odier Asset Management (USA) Corp |
109,084 |
1,310,000 |
1.78% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
101,550 |
1,219,000 |
1.66% |
|
|
| 16 |
ACUTA CAPITAL PARTNERS, LLC |
88,716 |
1,065,000 |
1.45% |
|
|
| 17 |
PRINCIPAL FINANCIAL GROUP INC |
73,600 |
884,000 |
1.20% |
|
|
| 18 |
PURA VIDA INVESTMENTS, LLC |
72,000 |
865,000 |
1.18% |
|
|
| 19 |
NORTHERN TRUST CORP |
67,361 |
809,000 |
1.10% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
64,228 |
771,000 |
1.05% |
|
|
| 21 |
C WorldWide Group Holding A/S |
71,700 |
756,000 |
1.03% |
|
|
| 22 |
Nicholas Investment Partners, LP |
56,601 |
680,000 |
0.93% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
40,720 |
489,000 |
0.67% |
|
|
| 24 |
STATE STREET CORP |
38,200 |
459,000 |
0.63% |
|
|
| 25 |
Bank of New York Mellon Corp |
35,030 |
421,000 |
0.57% |
|
|
| 26 |
BlackRock Investment Management, LLC |
20,400 |
245,000 |
0.33% |
|
|
| 27 |
PUTNAM INVESTMENTS LLC |
17,241 |
207,000 |
0.28% |
|
|
| 28 |
CREDIT SUISSE AG/ |
12,979 |
156,000 |
0.21% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,803 |
130,000 |
0.18% |
|
|
| 30 |
Abingworth LLP |
10,000 |
120,000 |
0.16% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,900 |
119,000 |
0.16% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,776 |
105,000 |
0.14% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
7,654 |
92,000 |
0.13% |
|
|
| 34 |
MORGAN STANLEY |
4,952 |
59,000 |
0.08% |
|
|
| 35 |
Nationwide Fund Advisors |
3,609 |
43,000 |
0.06% |
|
|
| 36 |
GILDER GAGNON HOWE & CO LLC |
3,301 |
40,000 |
0.05% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,190 |
38,000 |
0.05% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
2,873 |
35,000 |
0.05% |
|
|
| 39 |
UBS Group AG |
2,509 |
30,000 |
0.04% |
|
|
| 40 |
Tower Research Capital LLC (TRC) |
2,417 |
29,000 |
0.04% |
|
|
| 41 |
ROYCE & ASSOCIATES LP |
2,200 |
26,000 |
0.04% |
|
|
| 42 |
STRS OHIO |
1,800 |
21,000 |
0.03% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
1,386 |
16,646 |
0.02% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
722 |
9,000 |
0.01% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
533 |
6,000 |
0.01% |
|
|
| 46 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
375 |
4,000 |
0.01% |
|
|
| 47 |
ROYAL BANK OF CANADA |
251 |
3,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
28 |
0 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
22 |
0 |
0.00% |
|
|
