| 1 |
EcoR1 Capital, LLC |
908,691 |
15,629,000 |
15.86% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
723,209 |
12,388,000 |
12.57% |
|
|
| 3 |
FMR LLC |
612,396 |
10,533,000 |
10.69% |
|
|
| 4 |
AMERIPRISE FINANCIAL INC |
471,559 |
8,110,000 |
8.23% |
|
|
| 5 |
Capital World Investors |
343,250 |
5,904,000 |
5.99% |
|
|
| 6 |
PRIMECAP MANAGEMENT CO/CA/ |
326,200 |
5,611,000 |
5.69% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
300,000 |
5,160,000 |
5.24% |
|
|
| 8 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
253,118 |
4,353,630 |
4.42% |
|
|
| 9 |
Tekla Capital Management LLC |
232,600 |
4,001,000 |
4.06% |
|
|
| 10 |
LAZARD ASSET MANAGEMENT LLC |
180,750 |
3,108,000 |
3.15% |
|
|
| 11 |
VANGUARD GROUP INC |
160,974 |
2,769,000 |
2.81% |
|
|
| 12 |
BlackRock Fund Advisors |
147,106 |
2,530,000 |
2.57% |
|
|
| 13 |
JPMORGAN CHASE & CO |
131,575 |
2,263,000 |
2.30% |
|
|
| 14 |
Visium Asset Management, LP |
119,900 |
2,062,000 |
2.09% |
|
|
| 15 |
Lombard Odier Asset Management (USA) Corp |
103,318 |
1,777,000 |
1.80% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
101,355 |
1,743,000 |
1.77% |
|
|
| 17 |
ACUTA CAPITAL PARTNERS, LLC |
88,716 |
1,526,000 |
1.55% |
|
|
| 18 |
PRINCIPAL FINANCIAL GROUP INC |
73,600 |
1,266,000 |
1.28% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
61,714 |
1,061,000 |
1.08% |
|
|
| 20 |
NORTHERN TRUST CORP |
56,459 |
971,000 |
0.99% |
|
|
| 21 |
Nicholas Investment Partners, LP |
46,474 |
799,000 |
0.81% |
|
|
| 22 |
WALL STREET ASSOCIATES |
40,000 |
688,000 |
0.70% |
|
|
| 23 |
STATE STREET CORP |
38,432 |
661,000 |
0.67% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
35,259 |
606,000 |
0.61% |
|
|
| 25 |
Bank of New York Mellon Corp |
33,484 |
576,000 |
0.58% |
|
|
| 26 |
AWM Investment Company, Inc. |
25,000 |
430,000 |
0.44% |
|
|
| 27 |
BlackRock Investment Management, LLC |
21,107 |
363,000 |
0.37% |
|
|
| 28 |
PUTNAM INVESTMENTS LLC |
17,241 |
297,000 |
0.30% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,803 |
186,000 |
0.19% |
|
|
| 30 |
Abingworth LLP |
10,000 |
172,000 |
0.17% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,900 |
170,000 |
0.17% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
9,524 |
164,000 |
0.17% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
7,654 |
132,000 |
0.13% |
|
|
| 34 |
THOMPSON DAVIS & CO., INC. |
6,625 |
114,000 |
0.12% |
|
|
| 35 |
MORGAN STANLEY |
3,882 |
67,000 |
0.07% |
|
|
| 36 |
Nationwide Fund Advisors |
3,609 |
62,000 |
0.06% |
|
|
| 37 |
PANAGORA ASSET MANAGEMENT INC |
3,214 |
55,000 |
0.06% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,187 |
54,816 |
0.06% |
|
|
| 39 |
BLACKROCK ADVISORS LLC |
2,873 |
49,000 |
0.05% |
|
|
| 40 |
ROYCE & ASSOCIATES LP |
2,200 |
38,000 |
0.04% |
|
|
| 41 |
STRS OHIO |
1,800 |
30,000 |
0.03% |
|
|
| 42 |
PNC FINANCIAL SERVICES GROUP, INC. |
1,000 |
18,000 |
0.02% |
|
|
| 43 |
ROYAL BANK OF CANADA |
880 |
16,000 |
0.02% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
722 |
12,000 |
0.01% |
|
|
| 45 |
MANAGED ACCOUNT ADVISORS LLC |
597 |
10,000 |
0.01% |
|
|
| 46 |
BNP PARIBAS FINANCIAL MARKETS |
453 |
7,792 |
0.01% |
|
|
| 47 |
MAGEE THOMSON INVESTMENT PARTNERS LLC |
375 |
6,000 |
0.01% |
|
|
| 48 |
Invesco Ltd. |
279 |
5,000 |
0.01% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
272 |
5,000 |
0.01% |
|
|
| 50 |
BANK OF AMERICA CORP /DE/ |
202 |
3,000 |
0.00% |
|
|
