| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 795,088 | 9,899,000 | 12.08% | ||
| 2 | JENNISON ASSOCIATES LLC | 657,144 | 8,181,000 | 9.98% | ||
| 3 | AMERIPRISE FINANCIAL INC | 615,359 | 7,660,000 | 9.35% | ||
| 4 | FMR LLC | 600,796 | 7,480,000 | 9.13% | ||
| 5 | PRIMECAP MANAGEMENT CO/CA/ | 439,375 | 5,470,000 | 6.68% | ||
| 6 | BlackRock Fund Advisors | 360,577 | 4,489,000 | 5.48% | ||
| 7 | Capital World Investors | 357,562 | 4,452,000 | 5.43% | ||
| 8 | FRANKLIN RESOURCES INC | 356,100 | 4,433,000 | 5.41% | ||
| 9 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 251,081 | 3,126,000 | 3.82% | ||
| 10 | Tekla Capital Management LLC | 232,600 | 2,896,000 | 3.53% | ||
| 11 | JPMORGAN CHASE & CO | 225,953 | 2,813,000 | 3.43% | ||
| 12 | VANGUARD GROUP INC | 224,752 | 2,798,000 | 3.41% | ||
| 13 | LAZARD ASSET MANAGEMENT LLC | 165,950 | 2,066,000 | 2.52% | ||
| 14 | C WorldWide Group Holding A/S | 150,000 | 1,868,000 | 2.28% | ||
| 15 | PURA VIDA INVESTMENTS, LLC | 142,000 | 1,768,000 | 2.16% | ||
| 16 | PRINCIPAL FINANCIAL GROUP INC | 125,000 | 1,556,000 | 1.90% | ||
| 17 | Lombard Odier Asset Management (USA) Corp | 113,630 | 1,415,000 | 1.73% | ||
| 18 | ACUTA CAPITAL PARTNERS, LLC | 88,716 | 1,105,000 | 1.35% | ||
| 19 | NORTHERN TRUST CORP | 69,165 | 861,000 | 1.05% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 64,842 | 807,000 | 0.98% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 62,709 | 781,000 | 0.95% | ||
| 22 | Nicholas Investment Partners, LP | 57,035 | 710,000 | 0.87% | ||
| 23 | DEUTSCHE BANK AG\ | 51,392 | 638,000 | 0.78% | ||
| 24 | Spark Investment Management LLC | 47,600 | 592,000 | 0.72% | ||
| 25 | D. E. Shaw & Co., Inc. | 45,143 | 562,000 | 0.69% | ||
| 26 | STATE STREET CORP | 41,500 | 517,000 | 0.63% | ||
| 27 | Bank of New York Mellon Corp | 39,954 | 498,000 | 0.61% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 24,984 | 311,000 | 0.38% | ||
| 29 | BlackRock Investment Management, LLC | 20,591 | 256,000 | 0.31% | ||
| 30 | BLACKROCK ADVISORS LLC | 19,449 | 242,000 | 0.30% | ||
| 31 | PUTNAM INVESTMENTS LLC | 17,241 | 215,000 | 0.26% | ||
| 32 | GOLDMAN SACHS GROUP INC | 15,474 | 193,000 | 0.24% | ||
| 33 | ProShare Advisors LLC | 15,223 | 190,000 | 0.23% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 14,067 | 175,000 | 0.21% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 10,986 | 137,000 | 0.17% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,100 | 126,000 | 0.15% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 8,776 | 109,000 | 0.13% | ||
| 38 | TEACHERS ADVISORS, LLC | 7,654 | 95,000 | 0.12% | ||
| 39 | MORGAN STANLEY | 6,604 | 82,000 | 0.10% | ||
| 40 | CITADEL ADVISORS LLC | 4,778 | 59,000 | 0.07% | ||
| 41 | CITIGROUP INC | 4,113 | 51,000 | 0.06% | ||
| 42 | Nationwide Fund Advisors | 3,609 | 45,000 | 0.05% | ||
| 43 | GILDER GAGNON HOWE & CO LLC | 3,301 | 41,000 | 0.05% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 3,184 | 40,000 | 0.05% | ||
| 45 | ROYCE & ASSOCIATES LP | 2,200 | 27,000 | 0.03% | ||
| 46 | STRS OHIO | 1,800 | 22,000 | 0.03% | ||
| 47 | UBS Group AG | 1,371 | 17,000 | 0.02% | ||
| 48 | BlackRock Japan Co. Ltd | 1,322 | 16,000 | 0.02% | ||
| 49 | Joel Isaacson & Co., LLC | 850 | 11,000 | 0.01% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 722 | 9,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
