| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 2,696,405 | 46,513,000 | 45.22% | ||
| 2 | BVF INC/IL | 1,175,233 | 20,273,000 | 19.71% | ||
| 3 | Canaan Partners VII LLC | 610,434 | 10,530,000 | 10.24% | ||
| 4 | Abingworth LLP | 589,244 | 10,159,000 | 9.88% | ||
| 5 | VANGUARD GROUP INC | 261,493 | 4,511,000 | 4.39% | ||
| 6 | SPHERA FUNDS MANAGEMENT LTD. | 137,622 | 2,374,000 | 2.31% | ||
| 7 | GOLDMAN SACHS GROUP INC | 58,876 | 1,016,000 | 0.99% | ||
| 8 | BlackRock Fund Advisors | 55,956 | 965,000 | 0.94% | ||
| 9 | MORGAN STANLEY | 46,317 | 799,000 | 0.78% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 35,091 | 605,000 | 0.59% | ||
| 11 | Polar Capital LLP | 34,060 | 588,000 | 0.57% | ||
| 12 | DEUTSCHE BANK AG\ | 29,144 | 501,000 | 0.49% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 25,365 | 438,000 | 0.43% | ||
| 14 | Paloma Partners Management Co | 25,224 | 435,000 | 0.42% | ||
| 15 | STATE STREET CORP | 25,142 | 435,000 | 0.42% | ||
| 16 | TFS CAPITAL LLC | 23,685 | 409,000 | 0.40% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,000 | 345,000 | 0.34% | Call | |
| 18 | BLAIR WILLIAM & CO/IL | 18,100 | 312,000 | 0.30% | ||
| 19 | NORTHERN TRUST CORP | 17,987 | 310,000 | 0.30% | ||
| 20 | A.R.T. Advisors, LLC | 13,816 | 238,000 | 0.23% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 13,727 | 237,000 | 0.23% | ||
| 22 | Eidelman Virant Capital | 10,000 | 173,000 | 0.17% | ||
| 23 | BlackRock Investment Management, LLC | 7,812 | 135,000 | 0.13% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 6,439 | 111,000 | 0.11% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,396 | 76,000 | 0.07% | ||
| 26 | US BANCORP \DE\ | 4,400 | 76,000 | 0.07% | ||
| 27 | TEACHERS ADVISORS, LLC | 3,742 | 65,000 | 0.06% | ||
| 28 | Blume Capital Management, Inc. | 3,400 | 59,000 | 0.06% | ||
| 29 | NEW YORK STATE COMMON RETIREMENT FUND | 2,200 | 38,000 | 0.04% | ||
| 30 | AMERICAN INTERNATIONAL GROUP, INC. | 1,411 | 24,340 | 0.02% | ||
| 31 | Nationwide Fund Advisors | 1,268 | 22,000 | 0.02% | ||
| 32 | BLACKROCK ADVISORS LLC | 1,239 | 21,000 | 0.02% | ||
| 33 | CITIGROUP INC | 998 | 18,000 | 0.02% | ||
| 34 | Tower Research Capital LLC (TRC) | 774 | 13,000 | 0.01% | ||
| 35 | STRS OHIO | 577 | 9,000 | 0.01% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 436 | 8,000 | 0.01% | ||
| 37 | Invesco Ltd. | 291 | 5,000 | 0.00% | ||
| 38 | UBS Group AG | 167 | 3,000 | 0.00% | ||
| 39 | ROYAL BANK OF CANADA | 187 | 3,000 | 0.00% | ||
| 40 | WELLS FARGO & COMPANY/MN | 121 | 2,000 | 0.00% | ||
| 41 | BARCLAYS PLC | 47 | 1,000 | 0.00% | ||
| 42 | PNC FINANCIAL SERVICES GROUP, INC. | 66 | 1,000 | 0.00% | ||
| 43 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 55 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
