| 1 |
FRAZIER MANAGEMENT LLC |
2,668,570 |
26,819,000 |
22.42% |
|
|
| 2 |
Novo Holdings A/S |
2,471,405 |
24,838,000 |
20.76% |
|
|
| 3 |
FMR LLC |
1,540,248 |
15,479,000 |
12.94% |
|
|
| 4 |
BVF INC/IL |
1,253,401 |
12,597,000 |
10.53% |
|
|
| 5 |
STONEPINE CAPITAL MANAGEMENT, LLC |
833,377 |
8,375,000 |
7.00% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
877,342 |
7,792,000 |
6.51% |
|
|
| 7 |
Abingworth LLP |
589,244 |
5,898,000 |
4.93% |
|
|
| 8 |
EverPoint Asset Management, LLC |
362,254 |
3,641,000 |
3.04% |
|
|
| 9 |
VANGUARD GROUP INC |
315,144 |
3,167,000 |
2.65% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
187,622 |
1,886,000 |
1.58% |
|
|
| 11 |
DAFNA Capital Management LLC |
160,353 |
1,612,000 |
1.35% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
109,955 |
1,105,000 |
0.92% |
|
|
| 13 |
MARSHALL WACE, LLP |
107,493 |
1,080,000 |
0.90% |
|
|
| 14 |
OXFORD ASSET MANAGEMENT LLP |
74,787 |
750,000 |
0.63% |
|
|
| 15 |
BlackRock Fund Advisors |
67,417 |
678,000 |
0.57% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
40,532 |
407,000 |
0.34% |
|
|
| 17 |
TFS CAPITAL LLC |
40,384 |
406,000 |
0.34% |
|
|
| 18 |
NORTHERN TRUST CORP |
39,319 |
395,000 |
0.33% |
|
|
| 19 |
NEXTHERA CAPITAL LP |
35,000 |
352,000 |
0.29% |
|
|
| 20 |
RENAISSANCE TECHNOLOGIES LLC |
34,365 |
345,000 |
0.29% |
|
|
| 21 |
Polar Capital LLP |
34,061 |
342,000 |
0.29% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
31,424 |
315,000 |
0.26% |
|
|
| 23 |
Canaan Partners VII LLC |
23,806 |
239,000 |
0.20% |
|
|
| 24 |
Spark Investment Management LLC |
20,670 |
207,000 |
0.17% |
|
|
| 25 |
STATE STREET CORP |
15,081 |
151,000 |
0.13% |
|
|
| 26 |
BLACKROCK ADVISORS LLC |
11,449 |
115,000 |
0.10% |
|
|
| 27 |
BLAIR WILLIAM & CO/IL |
11,230 |
112,000 |
0.09% |
|
|
| 28 |
MORGAN STANLEY |
8,619 |
87,000 |
0.07% |
|
|
| 29 |
BlackRock Investment Management, LLC |
7,816 |
79,000 |
0.07% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
6,708 |
66,000 |
0.06% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
6,439 |
65,000 |
0.05% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
4,796 |
48,000 |
0.04% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
3,742 |
38,000 |
0.03% |
|
|
| 34 |
UBS Group AG |
2,504 |
25,000 |
0.02% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,200 |
22,000 |
0.02% |
|
|
| 36 |
Cubist Systematic Strategies, LLC |
1,494 |
15,000 |
0.01% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
1,348 |
14,000 |
0.01% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,409 |
14,000 |
0.01% |
|
|
| 39 |
Nationwide Fund Advisors |
1,268 |
13,000 |
0.01% |
|
|
| 40 |
BlackRock Japan Co. Ltd |
1,337 |
13,000 |
0.01% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
1,175 |
12,000 |
0.01% |
|
|
| 42 |
STRS OHIO |
577 |
5,000 |
0.00% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
246 |
2,472 |
0.00% |
|
|
| 44 |
PNC FINANCIAL SERVICES GROUP, INC. |
68 |
1,000 |
0.00% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
55 |
1,000 |
0.00% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
116 |
1,000 |
0.00% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
23 |
0 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
19 |
0 |
0.00% |
|
|
