| 1 |
FRAZIER MANAGEMENT LLC |
2,668,570 |
21,829,000 |
23.75% |
|
|
| 2 |
Novo Holdings A/S |
2,281,405 |
18,662,000 |
20.30% |
|
|
| 3 |
FMR LLC |
1,428,395 |
11,684,000 |
12.71% |
|
|
| 4 |
BVF INC/IL |
1,253,401 |
10,253,000 |
11.15% |
|
|
| 5 |
STONEPINE CAPITAL MANAGEMENT, LLC |
832,977 |
6,814,000 |
7.41% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
586,400 |
4,797,000 |
5.22% |
|
|
| 7 |
Abingworth LLP |
589,244 |
4,785,000 |
5.21% |
|
|
| 8 |
VANGUARD GROUP INC |
320,050 |
2,618,000 |
2.85% |
|
|
| 9 |
EverPoint Asset Management, LLC |
304,593 |
2,492,000 |
2.71% |
|
|
| 10 |
MARSHALL WACE, LLP |
196,216 |
1,605,000 |
1.75% |
|
|
| 11 |
SABBY MANAGEMENT, LLC |
100,000 |
818,000 |
0.89% |
|
|
| 12 |
DAFNA Capital Management LLC |
81,402 |
666,000 |
0.72% |
|
|
| 13 |
BlackRock Fund Advisors |
63,832 |
522,000 |
0.57% |
|
|
| 14 |
OXFORD ASSET MANAGEMENT LLP |
53,871 |
441,000 |
0.48% |
|
|
| 15 |
Polar Capital LLP |
50,000 |
409,000 |
0.44% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
45,468 |
372,000 |
0.40% |
|
|
| 17 |
NEXTHERA CAPITAL LP |
45,000 |
368,000 |
0.40% |
|
|
| 18 |
STATE STREET CORP |
42,875 |
351,000 |
0.38% |
|
|
| 19 |
NORTHERN TRUST CORP |
40,789 |
333,000 |
0.36% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
39,584 |
324,000 |
0.35% |
|
|
| 21 |
BLAIR WILLIAM & CO/IL |
37,230 |
304,000 |
0.33% |
|
|
| 22 |
SPHERA FUNDS MANAGEMENT LTD. |
32,300 |
264,000 |
0.29% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
32,223 |
263,000 |
0.29% |
|
|
| 24 |
RENAISSANCE TECHNOLOGIES LLC |
29,965 |
245,000 |
0.27% |
|
|
| 25 |
Canaan Partners VII LLC |
23,806 |
195,000 |
0.21% |
|
|
| 26 |
MORGAN STANLEY |
13,729 |
112,000 |
0.12% |
|
|
| 27 |
BlackRock Investment Management, LLC |
8,063 |
66,000 |
0.07% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
6,439 |
53,000 |
0.06% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
5,627 |
46,000 |
0.05% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
4,546 |
37,000 |
0.04% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
3,742 |
31,000 |
0.03% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
3,846 |
30,000 |
0.03% |
|
|
| 33 |
JPMORGAN CHASE & CO |
3,025 |
25,000 |
0.03% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,200 |
18,000 |
0.02% |
|
|
| 35 |
CITIGROUP INC |
1,838 |
15,000 |
0.02% |
|
|
| 36 |
BlackRock Japan Co. Ltd |
1,731 |
14,000 |
0.02% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,577 |
13,000 |
0.01% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,409 |
12,000 |
0.01% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
1,286 |
11,000 |
0.01% |
|
|
| 40 |
Nationwide Fund Advisors |
1,268 |
10,000 |
0.01% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
1,019 |
8,000 |
0.01% |
|
|
| 42 |
STRS OHIO |
577 |
4,000 |
0.00% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
270 |
2,000 |
0.00% |
|
|
| 44 |
Cubist Systematic Strategies, LLC |
216 |
2,000 |
0.00% |
|
|
| 45 |
PNC FINANCIAL SERVICES GROUP, INC. |
70 |
1,000 |
0.00% |
|
|
| 46 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
55 |
0 |
0.00% |
|
|
