| 1 |
Novo Holdings A/S |
2,696,405 |
26,047,000 |
36.67% |
|
|
| 2 |
FMR LLC |
1,279,588 |
12,361,000 |
17.40% |
|
|
| 3 |
BVF INC/IL |
1,175,233 |
11,353,000 |
15.98% |
|
|
| 4 |
Abingworth LLP |
589,244 |
5,657,000 |
7.96% |
|
|
| 5 |
EverPoint Asset Management, LLC |
340,000 |
3,284,000 |
4.62% |
|
|
| 6 |
VANGUARD GROUP INC |
307,435 |
2,970,000 |
4.18% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
174,943 |
1,690,000 |
2.38% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
137,622 |
1,329,000 |
1.87% |
|
|
| 9 |
MORGAN STANLEY |
106,601 |
1,030,000 |
1.45% |
|
|
| 10 |
Polar Capital LLP |
67,570 |
653,000 |
0.92% |
|
|
| 11 |
BlackRock Fund Advisors |
65,650 |
634,000 |
0.89% |
|
|
| 12 |
DAFNA Capital Management LLC |
45,092 |
436,000 |
0.61% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
39,977 |
386,000 |
0.54% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
39,831 |
385,000 |
0.54% |
|
|
| 15 |
RENAISSANCE TECHNOLOGIES LLC |
37,065 |
358,000 |
0.50% |
|
|
| 16 |
GOLDMAN SACHS GROUP INC |
28,766 |
278,000 |
0.39% |
|
|
| 17 |
TFS CAPITAL LLC |
26,455 |
256,000 |
0.36% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
25,836 |
249,000 |
0.35% |
|
|
| 19 |
Canaan Partners VII LLC |
23,806 |
230,000 |
0.32% |
|
|
| 20 |
NORTHERN TRUST CORP |
20,947 |
202,000 |
0.28% |
|
|
| 21 |
BLAIR WILLIAM & CO/IL |
18,100 |
174,000 |
0.24% |
|
|
| 22 |
STATE STREET CORP |
15,606 |
150,000 |
0.21% |
|
|
| 23 |
Eidelman Virant Capital |
15,000 |
145,000 |
0.20% |
|
|
| 24 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
15,000 |
145,000 |
0.20% |
Call |
|
| 25 |
A.R.T. Advisors, LLC |
12,860 |
124,000 |
0.17% |
|
|
| 26 |
BLACKROCK ADVISORS LLC |
9,756 |
94,000 |
0.13% |
|
|
| 27 |
BlackRock Investment Management, LLC |
7,703 |
74,000 |
0.10% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
6,783 |
64,000 |
0.09% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
6,439 |
62,000 |
0.09% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
4,396 |
42,000 |
0.06% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
3,742 |
36,000 |
0.05% |
|
|
| 32 |
Blume Capital Management, Inc. |
3,400 |
33,000 |
0.05% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,200 |
21,000 |
0.03% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,412 |
14,000 |
0.02% |
|
|
| 35 |
BlackRock Japan Co. Ltd |
1,501 |
14,000 |
0.02% |
|
|
| 36 |
UBS Group AG |
1,379 |
13,000 |
0.02% |
|
|
| 37 |
Nationwide Fund Advisors |
1,268 |
12,000 |
0.02% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
922 |
9,000 |
0.01% |
|
|
| 39 |
STRS OHIO |
577 |
5,000 |
0.01% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
498 |
4,811 |
0.01% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
365 |
4,000 |
0.01% |
|
|
| 42 |
Walleye Trading LLC |
200 |
2,000 |
0.00% |
|
|
| 43 |
Cubist Systematic Strategies, LLC |
178 |
2,000 |
0.00% |
|
|
| 44 |
ROYAL BANK OF CANADA |
229 |
2,000 |
0.00% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
55 |
1,000 |
0.00% |
|
|
| 46 |
PNC FINANCIAL SERVICES GROUP, INC. |
68 |
1,000 |
0.00% |
|
|
| 47 |
CITIGROUP INC |
108 |
1,000 |
0.00% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
116 |
1,000 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
12 |
0 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
11 |
0 |
0.00% |
|
|
