| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PNC FINANCIAL SERVICES GROUP, INC. | 68 | 1,000 | 0.00% | ||
| 2 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 55 | 1,000 | 0.00% | ||
| 3 | BlackRock Finance, Inc. | 277 | 3,000 | 0.00% | ||
| 4 | BNP PARIBAS FINANCIAL MARKETS | 342 | 4,296 | 0.00% | ||
| 5 | BANK OF AMERICA CORP /DE/ | 517 | 6,000 | 0.00% | ||
| 6 | STRS OHIO | 577 | 7,000 | 0.00% | ||
| 7 | UBS Group AG | 533 | 7,000 | 0.00% | ||
| 8 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 609 | 8,000 | 0.01% | ||
| 9 | MORGAN STANLEY | 1,000 | 13,000 | 0.01% | ||
| 10 | NEW YORK STATE COMMON RETIREMENT FUND | 2,200 | 28,000 | 0.02% | ||
| 11 | SIMPLEX TRADING, LLC | 2,302 | 28,000 | 0.02% | ||
| 12 | BLACKROCK ADVISORS LLC | 2,392 | 30,000 | 0.02% | ||
| 13 | AMERICAN INTERNATIONAL GROUP, INC. | 5,100 | 64,056 | 0.04% | ||
| 14 | Nationwide Fund Advisors | 5,411 | 68,000 | 0.05% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 11,135 | 140,000 | 0.10% | ||
| 16 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,029 | 177,000 | 0.12% | ||
| 17 | TEACHERS ADVISORS, LLC | 14,484 | 182,000 | 0.12% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 15,028 | 189,000 | 0.13% | ||
| 19 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,578 | 233,000 | 0.16% | ||
| 20 | BLAIR WILLIAM & CO/IL | 20,115 | 253,000 | 0.17% | ||
| 21 | DEUTSCHE BANK AG\ | 20,422 | 255,000 | 0.17% | ||
| 22 | Bank of New York Mellon Corp | 20,894 | 263,000 | 0.18% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 29,091 | 365,000 | 0.25% | ||
| 24 | BlackRock Investment Management, LLC | 32,210 | 405,000 | 0.28% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 32,633 | 409,000 | 0.28% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 37,265 | 468,000 | 0.32% | ||
| 27 | TFS CAPITAL LLC | 42,404 | 533,000 | 0.36% | ||
| 28 | NEXTHERA CAPITAL LP | 75,000 | 942,000 | 0.64% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 76,401 | 960,000 | 0.65% | ||
| 30 | STATE STREET CORP | 109,527 | 1,377,000 | 0.94% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 113,329 | 1,423,000 | 0.97% | ||
| 32 | NORTHERN TRUST CORP | 117,071 | 1,470,000 | 1.00% | ||
| 33 | EverPoint Asset Management, LLC | 150,000 | 1,884,000 | 1.29% | ||
| 34 | MARSHALL WACE, LLP | 168,769 | 2,120,000 | 1.45% | ||
| 35 | BlackRock Fund Advisors | 227,775 | 2,861,000 | 1.95% | ||
| 36 | AXA S.A. | 276,440 | 3,472,000 | 2.37% | ||
| 37 | VANGUARD GROUP INC | 339,175 | 4,260,000 | 2.91% | ||
| 38 | BB BIOTECH AG | 468,000 | 5,878,000 | 4.01% | ||
| 39 | Abingworth LLP | 589,244 | 7,377,000 | 5.03% | ||
| 40 | STONEPINE CAPITAL MANAGEMENT, LLC | 637,567 | 8,008,000 | 5.46% | ||
| 41 | FRANKLIN RESOURCES INC | 750,000 | 9,420,000 | 6.43% | ||
| 42 | BVF INC/IL | 1,253,401 | 15,743,000 | 10.74% | ||
| 43 | FMR LLC | 1,294,448 | 16,258,000 | 11.09% | ||
| 44 | Novo Holdings A/S | 2,027,091 | 25,460,000 | 17.37% | ||
| 45 | FRAZIER MANAGEMENT LLC | 2,668,570 | 33,517,000 | 22.87% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
