| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,420,000 | 120,118,000 | 15.21% | ||
| 2 | OAK RIDGE INVESTMENTS LLC | 2,963,400 | 55,446,000 | 7.02% | ||
| 3 | WELLS FARGO & COMPANY/MN | 2,803,913 | 52,462,000 | 6.64% | ||
| 4 | FRANKLIN RESOURCES INC | 2,465,718 | 46,134,000 | 5.84% | ||
| 5 | ArrowMark Colorado Holdings LLC | 2,197,840 | 41,122,000 | 5.21% | ||
| 6 | BAMCO INC /NY/ | 1,772,488 | 33,163,000 | 4.20% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,756,629 | 32,867,000 | 4.16% | ||
| 8 | VANGUARD GROUP INC | 1,706,703 | 31,933,000 | 4.04% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,250,000 | 23,388,000 | 2.96% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,154,870 | 21,608,000 | 2.74% | ||
| 11 | Novo Holdings A/S | 1,117,002 | 20,899,000 | 2.65% | ||
| 12 | Polar Capital LLP | 1,110,000 | 20,768,000 | 2.63% | ||
| 13 | BlackRock Fund Advisors | 1,013,863 | 18,969,000 | 2.40% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 987,973 | 18,484,000 | 2.34% | ||
| 15 | OppenheimerFunds, Inc. | 885,011 | 16,559,000 | 2.10% | ||
| 16 | Wellington Shields & Co., LLC | 747,984 | 13,995,000 | 1.77% | ||
| 17 | STATE STREET CORP | 720,258 | 13,475,000 | 1.71% | ||
| 18 | TAMARACK ADVISERS, LP | 714,200 | 13,363,000 | 1.69% | ||
| 19 | NORTHERN TRUST CORP | 678,225 | 12,689,000 | 1.61% | ||
| 20 | Elk Creek Partners, LLC | 503,698 | 9,424,000 | 1.19% | ||
| 21 | CHARTWELL INVESTMENT PARTNERS, LLC | 430,719 | 8,059,000 | 1.02% | ||
| 22 | Redmile Group, LLC | 401,836 | 7,518,000 | 0.95% | ||
| 23 | BALYASNY ASSET MANAGEMENT L.P. | 400,000 | 7,484,000 | 0.95% | ||
| 24 | Ghost Tree Capital, LLC | 375,000 | 7,016,000 | 0.89% | ||
| 25 | Cortina Asset Management, LLC | 365,967 | 6,847,000 | 0.87% | ||
| 26 | Artal Group S.A. | 350,000 | 6,549,000 | 0.83% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 323,070 | 6,044,000 | 0.77% | ||
| 28 | Pier Capital, LLC | 293,200 | 5,486,000 | 0.69% | ||
| 29 | Point72 Asset Management, L.P. | 276,800 | 5,179,000 | 0.66% | ||
| 30 | PFM Health Sciences, LP | 258,019 | 4,828,000 | 0.61% | ||
| 31 | BRIDGER MANAGEMENT, LLC | 256,473 | 4,799,000 | 0.61% | ||
| 32 | CASTLEARK MANAGEMENT LLC | 251,445 | 4,705,000 | 0.60% | ||
| 33 | Bank of New York Mellon Corp | 249,641 | 4,670,000 | 0.59% | ||
| 34 | Endurant Capital Management LP | 243,626 | 4,558,000 | 0.58% | ||
| 35 | DISCIPLINED GROWTH INVESTORS INC /MN | 236,211 | 4,420,000 | 0.56% | ||
| 36 | AMERIPRISE FINANCIAL INC | 216,235 | 4,045,000 | 0.51% | ||
| 37 | First Light Asset Management, LLC | 198,219 | 3,709,000 | 0.47% | ||
| 38 | PURA VIDA INVESTMENTS, LLC | 175,000 | 3,274,000 | 0.41% | ||
| 39 | Nicholas Investment Partners, LP | 163,463 | 3,058,000 | 0.39% | ||
| 40 | BlackRock Investment Management, LLC | 160,274 | 2,999,000 | 0.38% | ||
| 41 | C WorldWide Group Holding A/S | 159,956 | 2,993,000 | 0.38% | ||
| 42 | PNC FINANCIAL SERVICES GROUP, INC. | 155,442 | 2,908,000 | 0.37% | ||
| 43 | Granahan Investment Management, LLC | 154,118 | 2,884,000 | 0.37% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 148,056 | 2,771,000 | 0.35% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 134,642 | 2,519,000 | 0.32% | ||
| 46 | PUTNAM INVESTMENTS LLC | 129,953 | 2,431,000 | 0.31% | ||
| 47 | CITADEL ADVISORS LLC | 123,499 | 2,311,000 | 0.29% | ||
| 48 | WOLVERINE ASSET MANAGEMENT LLC | 116,400 | 2,177,000 | 0.28% | Put | |
| 49 | Iguana Healthcare Management, LLC | 110,000 | 2,058,000 | 0.26% | ||
| 50 | D. E. Shaw & Co., Inc. | 108,735 | 2,034,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
