| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,376,762 | 131,731,000 | 13.38% | ||
| 2 | ArrowMark Colorado Holdings LLC | 2,602,148 | 63,753,000 | 6.47% | ||
| 3 | OAK RIDGE INVESTMENTS LLC | 2,241,535 | 54,918,000 | 5.58% | ||
| 4 | FRANKLIN RESOURCES INC | 2,099,971 | 51,449,000 | 5.22% | ||
| 5 | VANGUARD GROUP INC | 1,753,578 | 42,962,000 | 4.36% | ||
| 6 | BAMCO INC /NY/ | 1,540,500 | 37,742,000 | 3.83% | ||
| 7 | WELLS FARGO & COMPANY/MN | 1,415,120 | 34,670,000 | 3.52% | ||
| 8 | PFM Health Sciences, LP | 1,365,945 | 33,466,000 | 3.40% | ||
| 9 | BlackRock Fund Advisors | 1,267,501 | 31,054,000 | 3.15% | ||
| 10 | Polar Capital LLP | 1,185,000 | 29,027,000 | 2.95% | ||
| 11 | Novo Holdings A/S | 1,179,122 | 28,889,000 | 2.93% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,160,768 | 28,439,000 | 2.89% | ||
| 13 | WELLINGTON MANAGEMENT GROUP LLP | 1,157,607 | 28,361,000 | 2.88% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 1,121,614 | 27,480,000 | 2.79% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,050,000 | 25,725,000 | 2.61% | ||
| 16 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 942,149 | 23,083,000 | 2.34% | ||
| 17 | Wellington Shields & Co., LLC | 878,451 | 21,522,000 | 2.19% | ||
| 18 | STATE STREET CORP | 804,682 | 19,715,000 | 2.00% | ||
| 19 | LOOMIS SAYLES & CO L P | 722,592 | 17,704,000 | 1.80% | ||
| 20 | OppenheimerFunds, Inc. | 625,142 | 15,316,000 | 1.56% | ||
| 21 | NORTHERN TRUST CORP | 623,033 | 15,264,000 | 1.55% | ||
| 22 | Granahan Investment Management, LLC | 577,150 | 14,140,000 | 1.44% | ||
| 23 | Cortina Asset Management, LLC | 485,563 | 11,896,000 | 1.21% | ||
| 24 | BNP Paribas Asset Management Holding S.A. | 400,245 | 9,806,000 | 1.00% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 364,170 | 8,922,000 | 0.91% | ||
| 26 | Ghost Tree Capital, LLC | 335,000 | 8,208,000 | 0.83% | ||
| 27 | TAMARACK ADVISERS, LP | 329,600 | 8,075,000 | 0.82% | ||
| 28 | LORD, ABBETT & CO. LLC | 277,083 | 6,788,000 | 0.69% | ||
| 29 | CASTLEARK MANAGEMENT LLC | 267,840 | 6,562,000 | 0.67% | ||
| 30 | DISCIPLINED GROWTH INVESTORS INC /MN | 240,911 | 5,902,000 | 0.60% | ||
| 31 | Bank of New York Mellon Corp | 225,365 | 5,522,000 | 0.56% | ||
| 32 | DEUTSCHE BANK AG\ | 215,594 | 5,280,000 | 0.54% | ||
| 33 | AMERIPRISE FINANCIAL INC | 199,075 | 4,877,000 | 0.50% | ||
| 34 | CHARTWELL INVESTMENT PARTNERS, LLC | 196,180 | 4,806,000 | 0.49% | ||
| 35 | Redmile Group, LLC | 187,627 | 4,597,000 | 0.47% | ||
| 36 | First Light Asset Management, LLC | 183,727 | 4,501,000 | 0.46% | ||
| 37 | D. E. Shaw & Co., Inc. | 176,613 | 4,327,000 | 0.44% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 170,554 | 4,179,000 | 0.42% | ||
| 39 | TWO SIGMA INVESTMENTS, LP | 166,997 | 4,091,000 | 0.42% | ||
| 40 | BlackRock Investment Management, LLC | 159,857 | 3,916,000 | 0.40% | ||
| 41 | TWO SIGMA ADVISERS, LP | 158,399 | 3,881,000 | 0.39% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 154,615 | 3,788,000 | 0.38% | ||
| 43 | BALYASNY ASSET MANAGEMENT L.P. | 150,220 | 3,680,000 | 0.37% | ||
| 44 | MORGAN STANLEY | 145,881 | 3,574,000 | 0.36% | ||
| 45 | HUSSMAN STRATEGIC ADVISORS, INC. | 140,000 | 3,430,000 | 0.35% | ||
| 46 | EverPoint Asset Management, LLC | 125,000 | 3,063,000 | 0.31% | ||
| 47 | Pier Capital, LLC | 117,146 | 2,870,000 | 0.29% | ||
| 48 | C WorldWide Group Holding A/S | 110,000 | 2,695,000 | 0.27% | ||
| 49 | Iguana Healthcare Management, LLC | 110,000 | 2,695,000 | 0.27% | ||
| 50 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 106,211 | 2,602,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
