| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,001,127 | 125,478,000 | 12.49% | ||
| 2 | OAK RIDGE INVESTMENTS LLC | 2,736,522 | 68,660,000 | 6.83% | ||
| 3 | FRANKLIN RESOURCES INC | 2,233,573 | 56,041,000 | 5.58% | ||
| 4 | ArrowMark Colorado Holdings LLC | 1,995,534 | 50,068,000 | 4.98% | ||
| 5 | VANGUARD GROUP INC | 1,727,371 | 43,340,000 | 4.31% | ||
| 6 | WELLS FARGO & COMPANY/MN | 1,575,975 | 39,541,000 | 3.94% | ||
| 7 | BAMCO INC /NY/ | 1,528,500 | 38,350,000 | 3.82% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,235,550 | 31,000,000 | 3.09% | ||
| 9 | Novo Holdings A/S | 1,155,722 | 28,997,000 | 2.89% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,146,059 | 28,755,000 | 2.86% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 1,134,860 | 28,475,000 | 2.83% | ||
| 12 | Polar Capital LLP | 1,110,000 | 27,849,000 | 2.77% | ||
| 13 | BlackRock Fund Advisors | 1,085,109 | 27,225,000 | 2.71% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 23,836,000 | 2.37% | ||
| 15 | Wellington Shields & Co., LLC | 878,451 | 22,040,000 | 2.19% | ||
| 16 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 851,958 | 21,376,000 | 2.13% | ||
| 17 | STATE STREET CORP | 781,937 | 19,622,000 | 1.95% | ||
| 18 | NORTHERN TRUST CORP | 681,138 | 17,089,000 | 1.70% | ||
| 19 | Granahan Investment Management, LLC | 632,668 | 15,874,000 | 1.58% | ||
| 20 | OppenheimerFunds, Inc. | 601,406 | 15,089,000 | 1.50% | ||
| 21 | CHARTWELL INVESTMENT PARTNERS, LLC | 535,009 | 13,423,000 | 1.34% | ||
| 22 | TAMARACK ADVISERS, LP | 500,000 | 12,315,000 | 1.23% | ||
| 23 | Ghost Tree Capital, LLC | 435,000 | 10,914,000 | 1.09% | ||
| 24 | Elk Creek Partners, LLC | 426,486 | 10,701,000 | 1.07% | ||
| 25 | LORD, ABBETT & CO. LLC | 393,290 | 9,868,000 | 0.98% | ||
| 26 | COLUMBUS CIRCLE INVESTORS | 362,846 | 9,104,000 | 0.91% | ||
| 27 | Cortina Asset Management, LLC | 355,976 | 8,931,000 | 0.89% | ||
| 28 | Redmile Group, LLC | 334,741 | 8,399,000 | 0.84% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 317,858 | 7,975,000 | 0.79% | ||
| 30 | BNP Paribas Asset Management Holding S.A. | 304,355 | 7,636,000 | 0.76% | ||
| 31 | CASTLEARK MANAGEMENT LLC | 277,050 | 6,951,000 | 0.69% | ||
| 32 | Bank of New York Mellon Corp | 268,272 | 6,732,000 | 0.67% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 265,129 | 6,652,000 | 0.66% | ||
| 34 | AMERIPRISE FINANCIAL INC | 243,447 | 6,107,000 | 0.61% | ||
| 35 | DISCIPLINED GROWTH INVESTORS INC /MN | 231,336 | 5,804,000 | 0.58% | ||
| 36 | Pier Capital, LLC | 229,806 | 5,766,000 | 0.57% | ||
| 37 | D. E. Shaw & Co., Inc. | 218,059 | 5,471,000 | 0.54% | ||
| 38 | DEUTSCHE BANK AG\ | 203,885 | 5,113,000 | 0.51% | ||
| 39 | Artal Group S.A. | 200,000 | 5,018,000 | 0.50% | ||
| 40 | First Light Asset Management, LLC | 194,011 | 4,868,000 | 0.48% | ||
| 41 | PFM Health Sciences, LP | 168,045 | 4,216,000 | 0.42% | ||
| 42 | Nicholas Investment Partners, LP | 163,463 | 4,101,000 | 0.41% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 161,093 | 4,042,000 | 0.40% | ||
| 44 | BlackRock Investment Management, LLC | 160,059 | 4,016,000 | 0.40% | ||
| 45 | C WorldWide Group Holding A/S | 159,956 | 4,013,000 | 0.40% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 155,852 | 3,911,000 | 0.39% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,100 | 3,841,000 | 0.38% | Call | |
| 48 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 134,922 | 3,385,000 | 0.34% | ||
| 49 | Point72 Asset Management, L.P. | 129,900 | 3,259,000 | 0.32% | ||
| 50 | MACQUARIE GROUP LTD | 116,857 | 2,932,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
