| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,650,000 | 95,211,000 | 30.47% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,186,551 | 37,428,000 | 11.98% | ||
| 3 | Abingworth LLP | 3,600,000 | 32,148,000 | 10.29% | ||
| 4 | AMERIPRISE FINANCIAL INC | 1,857,351 | 16,604,000 | 5.31% | ||
| 5 | ARDSLEY ADVISORY PARTNERS LP | 1,590,000 | 14,215,000 | 4.55% | ||
| 6 | Murphy Michael R | 1,345,031 | 12,025,000 | 3.85% | ||
| 7 | NORTHPOINTE CAPITAL LLC | 1,069,898 | 9,564,000 | 3.06% | ||
| 8 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,052,150 | 9,406,000 | 3.01% | ||
| 9 | BlackRock Fund Advisors | 975,519 | 8,721,000 | 2.79% | ||
| 10 | Orchard Hill Capital Management LP | 828,000 | 7,402,000 | 2.37% | Call | |
| 11 | ORBIMED ADVISORS LLC | 580,000 | 5,185,000 | 1.66% | ||
| 12 | VANGUARD GROUP INC | 528,561 | 4,725,000 | 1.51% | ||
| 13 | Orchard Hill Capital Management LP | 500,754 | 4,477,000 | 1.43% | ||
| 14 | GROUP ONE TRADING LLC | 329,801 | 2,948,000 | 0.94% | ||
| 15 | J. Goldman & Co LP | 306,150 | 2,737,000 | 0.88% | ||
| 16 | MORGAN STANLEY | 305,877 | 2,735,000 | 0.88% | ||
| 17 | BANK OF AMERICA CORP /DE/ | 255,028 | 2,280,000 | 0.73% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 250,000 | 2,235,000 | 0.72% | Put | |
| 19 | FRANKLIN STREET ADVISORS INC /NC | 239,900 | 2,145,000 | 0.69% | ||
| 20 | STATE STREET CORP | 238,836 | 2,134,000 | 0.68% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 215,500 | 1,927,000 | 0.62% | ||
| 22 | WHITEBOX ADVISORS LLC | 206,917 | 1,850,000 | 0.59% | ||
| 23 | NORTHERN TRUST CORP | 202,868 | 1,814,000 | 0.58% | ||
| 24 | Healthcare Value Capital, LLC | 200,000 | 1,788,000 | 0.57% | Call | |
| 25 | Rhenman & Partners Asset Management AB | 196,537 | 1,757,000 | 0.56% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 194,071 | 1,735,000 | 0.56% | ||
| 27 | KOPP INVESTMENT ADVISORS LLC | 165,830 | 1,483,000 | 0.47% | ||
| 28 | Perimeter Capital Partners, LLC | 156,455 | 1,399,000 | 0.45% | ||
| 29 | D. E. Shaw & Co., Inc. | 152,442 | 1,363,000 | 0.44% | ||
| 30 | REINHART PARTNERS, LLC. | 152,031 | 1,359,000 | 0.43% | ||
| 31 | Tekla Capital Management LLC | 140,800 | 1,259,000 | 0.40% | ||
| 32 | PANAGORA ASSET MANAGEMENT INC | 138,911 | 1,242,000 | 0.40% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,600 | 1,114,000 | 0.36% | Put | |
| 34 | TD ASSET MANAGEMENT INC | 115,100 | 1,029,000 | 0.33% | ||
| 35 | Healthcare Value Capital, LLC | 106,735 | 954,000 | 0.31% | ||
| 36 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 104,500 | 934,000 | 0.30% | ||
| 37 | Iguana Healthcare Management, LLC | 100,000 | 894,000 | 0.29% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,600 | 792,000 | 0.25% | Call | |
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 85,534 | 764,000 | 0.24% | ||
| 40 | CREDIT SUISSE AG/ | 84,727 | 757,000 | 0.24% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,214 | 744,000 | 0.24% | ||
| 42 | CITADEL ADVISORS LLC | 79,926 | 715,000 | 0.23% | ||
| 43 | Bank of New York Mellon Corp | 77,873 | 696,000 | 0.22% | ||
| 44 | DRIEHAUS CAPITAL MANAGEMENT LLC | 68,149 | 609,000 | 0.19% | ||
| 45 | BlackRock Investment Management, LLC | 54,445 | 487,000 | 0.16% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,205 | 476,000 | 0.15% | ||
| 47 | Airain ltd | 51,395 | 459,000 | 0.15% | ||
| 48 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 447,000 | 0.14% | ||
| 49 | BOLTON LP | 50,000 | 447,000 | 0.14% | ||
| 50 | BOLTON LP | 50,000 | 447,000 | 0.14% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
