| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,650,000 | 92,549,000 | 29.71% | ||
| 2 | Murphy Michael R | 2,896,222 | 25,168,000 | 8.08% | ||
| 3 | Abingworth LLP | 2,879,328 | 25,021,000 | 8.03% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,357,650 | 20,488,000 | 6.58% | ||
| 5 | ARDSLEY ADVISORY PARTNERS LP | 1,815,000 | 15,772,000 | 5.06% | ||
| 6 | AMERIPRISE FINANCIAL INC | 1,470,097 | 12,775,000 | 4.10% | ||
| 7 | BlackRock Fund Advisors | 1,213,913 | 10,549,000 | 3.39% | ||
| 8 | Orchard Hill Capital Management LP | 1,144,514 | 9,946,000 | 3.19% | ||
| 9 | NORTHPOINTE CAPITAL LLC | 1,134,447 | 9,858,000 | 3.16% | ||
| 10 | VANGUARD GROUP INC | 772,920 | 6,717,000 | 2.16% | ||
| 11 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 740,753 | 6,437,000 | 2.07% | ||
| 12 | KOPP INVESTMENT ADVISORS LLC | 721,065 | 6,266,000 | 2.01% | ||
| 13 | Iguana Healthcare Management, LLC | 600,000 | 5,215,000 | 1.67% | ||
| 14 | ORBIMED ADVISORS LLC | 580,000 | 5,040,000 | 1.62% | ||
| 15 | Jefferies Group LLC | 508,536 | 4,419,000 | 1.42% | ||
| 16 | WHITEBOX ADVISORS LLC | 424,291 | 3,687,000 | 1.18% | ||
| 17 | Bruce & Co., Inc. | 400,000 | 3,476,000 | 1.12% | ||
| 18 | NORTHERN TRUST CORP | 307,468 | 2,672,000 | 0.86% | ||
| 19 | STATE STREET CORP | 286,662 | 2,490,000 | 0.80% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 280,327 | 2,436,000 | 0.78% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 272,545 | 2,368,000 | 0.76% | ||
| 22 | EVENTIDE ASSET MANAGEMENT, LLC | 257,000 | 2,233,000 | 0.72% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 227,400 | 1,976,000 | 0.63% | ||
| 24 | FRANKLIN STREET ADVISORS INC /NC | 223,075 | 1,939,000 | 0.62% | ||
| 25 | Rhenman & Partners Asset Management AB | 212,000 | 1,842,000 | 0.59% | ||
| 26 | Allianz Asset Management GmbH | 205,277 | 1,784,000 | 0.57% | ||
| 27 | CITADEL ADVISORS LLC | 194,946 | 1,694,000 | 0.54% | ||
| 28 | A.R.T. Advisors, LLC | 170,355 | 1,480,000 | 0.48% | ||
| 29 | Timpani Capital Management LLC | 156,236 | 1,358,000 | 0.44% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 146,498 | 1,273,000 | 0.41% | ||
| 31 | Bank of New York Mellon Corp | 143,608 | 1,248,000 | 0.40% | ||
| 32 | PANAGORA ASSET MANAGEMENT INC | 139,011 | 1,208,000 | 0.39% | ||
| 33 | REINHART PARTNERS, LLC. | 129,411 | 1,125,000 | 0.36% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 119,500 | 1,038,000 | 0.33% | Call | |
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 116,661 | 1,014,000 | 0.33% | ||
| 36 | ESSEX INVESTMENT MANAGEMENT CO LLC | 109,130 | 948,000 | 0.30% | ||
| 37 | TFS CAPITAL LLC | 102,515 | 891,000 | 0.29% | ||
| 38 | Alyeska Investment Group, L.P. | 99,547 | 865,000 | 0.28% | ||
| 39 | BlackRock Investment Management, LLC | 85,644 | 744,000 | 0.24% | ||
| 40 | CREDIT SUISSE AG/ | 83,627 | 726,000 | 0.23% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,800 | 720,000 | 0.23% | Put | |
| 42 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 80,000 | 695,000 | 0.22% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 76,600 | 666,000 | 0.21% | ||
| 44 | D. E. Shaw & Co., Inc. | 68,543 | 596,000 | 0.19% | ||
| 45 | MORGAN STANLEY | 54,573 | 475,000 | 0.15% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,052 | 470,000 | 0.15% | ||
| 47 | TD ASSET MANAGEMENT INC | 53,600 | 466,000 | 0.15% | ||
| 48 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,550 | 439,000 | 0.14% | ||
| 49 | TEACHERS ADVISORS, LLC | 50,065 | 435,000 | 0.14% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 49,300 | 428,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
