| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,650,000 | 115,553,000 | 28.02% | ||
| 2 | Abingworth LLP | 3,600,000 | 39,348,000 | 9.54% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,428,890 | 37,546,000 | 9.10% | ||
| 4 | Murphy Michael R | 2,506,346 | 27,444,000 | 6.65% | ||
| 5 | ARDSLEY ADVISORY PARTNERS LP | 1,765,000 | 19,327,000 | 4.69% | ||
| 6 | AMERIPRISE FINANCIAL INC | 1,732,581 | 18,972,000 | 4.60% | ||
| 7 | Consonance Capital Management LP | 1,440,008 | 15,768,000 | 3.82% | ||
| 8 | Orchard Hill Capital Management LP | 1,269,457 | 13,901,000 | 3.37% | ||
| 9 | BlackRock Fund Advisors | 1,205,400 | 13,199,000 | 3.20% | ||
| 10 | NORTHPOINTE CAPITAL LLC | 1,019,819 | 11,167,000 | 2.71% | ||
| 11 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 807,563 | 8,843,000 | 2.14% | ||
| 12 | KOPP INVESTMENT ADVISORS LLC | 664,470 | 7,276,000 | 1.76% | ||
| 13 | VANGUARD GROUP INC | 657,835 | 7,203,000 | 1.75% | ||
| 14 | ORBIMED ADVISORS LLC | 580,000 | 6,351,000 | 1.54% | ||
| 15 | NEXT CENTURY GROWTH INVESTORS LLC | 461,467 | 5,053,000 | 1.23% | ||
| 16 | Iguana Healthcare Management, LLC | 375,000 | 4,107,000 | 1.00% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 305,740 | 3,348,000 | 0.81% | ||
| 18 | STATE STREET CORP | 267,984 | 2,937,000 | 0.71% | ||
| 19 | WHITEBOX ADVISORS LLC | 254,244 | 2,784,000 | 0.68% | ||
| 20 | Jefferies Group LLC | 250,472 | 2,743,000 | 0.67% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 240,600 | 2,635,000 | 0.64% | ||
| 22 | NORTHERN TRUST CORP | 235,970 | 2,583,000 | 0.63% | ||
| 23 | Rhenman & Partners Asset Management AB | 227,000 | 2,486,000 | 0.60% | ||
| 24 | Allianz Asset Management GmbH | 221,300 | 2,423,000 | 0.59% | ||
| 25 | FRANKLIN STREET ADVISORS INC /NC | 216,350 | 2,369,000 | 0.57% | ||
| 26 | Healthcare Value Capital, LLC | 200,000 | 2,190,000 | 0.53% | Call | |
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 188,000 | 2,059,000 | 0.50% | Call | |
| 28 | BANK OF AMERICA CORP /DE/ | 160,600 | 1,759,000 | 0.43% | Call | |
| 29 | REINHART PARTNERS, LLC. | 153,031 | 1,676,000 | 0.41% | ||
| 30 | Perimeter Capital Partners, LLC | 150,059 | 1,643,000 | 0.40% | ||
| 31 | PANAGORA ASSET MANAGEMENT INC | 146,302 | 1,602,000 | 0.39% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 140,739 | 1,541,000 | 0.37% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 131,461 | 1,439,000 | 0.35% | ||
| 34 | D. E. Shaw & Co., Inc. | 126,285 | 1,383,000 | 0.34% | ||
| 35 | Bank of New York Mellon Corp | 124,746 | 1,366,000 | 0.33% | ||
| 36 | Bruce & Co., Inc. | 100,000 | 1,095,000 | 0.27% | ||
| 37 | MOORE CAPITAL MANAGEMENT, LP | 100,000 | 1,095,000 | 0.27% | ||
| 38 | JANE STREET GROUP, LLC | 99,268 | 1,087,000 | 0.26% | ||
| 39 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 92,000 | 1,007,000 | 0.24% | ||
| 40 | AQR CAPITAL MANAGEMENT LLC | 91,200 | 999,000 | 0.24% | ||
| 41 | GROUP ONE TRADING LLC | 89,882 | 984,000 | 0.24% | ||
| 42 | BlackRock Investment Management, LLC | 84,276 | 923,000 | 0.22% | ||
| 43 | TD ASSET MANAGEMENT INC | 79,700 | 873,000 | 0.21% | ||
| 44 | MORGAN STANLEY | 73,974 | 810,000 | 0.20% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,445 | 585,000 | 0.14% | ||
| 46 | TEACHERS ADVISORS, LLC | 50,065 | 548,000 | 0.13% | ||
| 47 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 548,000 | 0.13% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,500 | 542,000 | 0.13% | Put | |
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 49,300 | 540,000 | 0.13% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,000 | 471,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
