| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,650,000 | 128,759,000 | 26.10% | ||
| 2 | Consonance Capital Management LP | 3,566,923 | 43,124,000 | 8.74% | ||
| 3 | Murphy Michael R | 2,644,571 | 31,973,000 | 6.48% | ||
| 4 | Abingworth LLP | 2,303,462 | 27,826,000 | 5.64% | ||
| 5 | AMERIPRISE FINANCIAL INC | 1,427,997 | 17,264,000 | 3.50% | ||
| 6 | BlackRock Fund Advisors | 1,356,816 | 16,404,000 | 3.33% | ||
| 7 | NORTHPOINTE CAPITAL LLC | 1,208,258 | 14,608,000 | 2.96% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,061,450 | 12,833,000 | 2.60% | ||
| 9 | ARDSLEY ADVISORY PARTNERS LP | 981,300 | 11,864,000 | 2.41% | ||
| 10 | VANGUARD GROUP INC | 885,629 | 10,708,000 | 2.17% | ||
| 11 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 722,991 | 8,741,000 | 1.77% | ||
| 12 | Bruce & Co., Inc. | 694,581 | 8,334,000 | 1.69% | ||
| 13 | ASHFORD CAPITAL MANAGEMENT INC | 679,987 | 8,221,000 | 1.67% | ||
| 14 | KENNEDY CAPITAL MANAGEMENT LLC | 669,954 | 8,100,000 | 1.64% | ||
| 15 | KOPP INVESTMENT ADVISORS LLC | 613,590 | 7,418,000 | 1.50% | ||
| 16 | ORBIMED ADVISORS LLC | 580,000 | 7,012,000 | 1.42% | ||
| 17 | AlphaOne Investment Services, LLC | 558,961 | 6,758,000 | 1.37% | ||
| 18 | Opaleye Management Inc. | 535,000 | 6,468,000 | 1.31% | ||
| 19 | Iguana Healthcare Management, LLC | 500,000 | 6,045,000 | 1.23% | ||
| 20 | WHITEBOX ADVISORS LLC | 454,796 | 5,498,000 | 1.11% | ||
| 21 | Rhenman & Partners Asset Management AB | 450,800 | 5,450,000 | 1.10% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 423,938 | 5,125,000 | 1.04% | ||
| 23 | C WorldWide Group Holding A/S | 380,000 | 4,594,000 | 0.93% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 375,432 | 4,539,000 | 0.92% | ||
| 25 | STATE STREET CORP | 362,515 | 4,383,000 | 0.89% | ||
| 26 | WELLS FARGO & COMPANY/MN | 361,314 | 4,370,000 | 0.89% | ||
| 27 | NORTHERN TRUST CORP | 313,023 | 3,784,000 | 0.77% | ||
| 28 | EVENTIDE ASSET MANAGEMENT, LLC | 286,600 | 3,465,000 | 0.70% | ||
| 29 | PANAGORA ASSET MANAGEMENT INC | 233,484 | 2,823,000 | 0.57% | ||
| 30 | Allianz Asset Management GmbH | 225,862 | 2,731,000 | 0.55% | ||
| 31 | TWO SIGMA INVESTMENTS, LP | 216,110 | 2,613,000 | 0.53% | ||
| 32 | CITADEL ADVISORS LLC | 190,404 | 2,302,000 | 0.47% | ||
| 33 | MENTA CAPITAL LLC | 168,597 | 2,038,000 | 0.41% | ||
| 34 | Spark Investment Management LLC | 166,300 | 2,008,000 | 0.41% | ||
| 35 | DRIEHAUS CAPITAL MANAGEMENT LLC | 160,511 | 1,941,000 | 0.39% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 154,205 | 1,864,000 | 0.38% | ||
| 37 | Ranger Investment Management, L.P. | 151,500 | 1,832,000 | 0.37% | ||
| 38 | FRANKLIN STREET ADVISORS INC /NC | 146,325 | 1,769,000 | 0.36% | ||
| 39 | TFS CAPITAL LLC | 143,529 | 1,735,000 | 0.35% | ||
| 40 | ZAZOVE ASSOCIATES LLC | 138,429 | 1,674,000 | 0.34% | ||
| 41 | Granite Investment Partners, LLC | 134,396 | 1,625,000 | 0.33% | ||
| 42 | AQR CAPITAL MANAGEMENT LLC | 133,471 | 1,614,000 | 0.33% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 133,270 | 1,611,000 | 0.33% | ||
| 44 | Bank of New York Mellon Corp | 129,501 | 1,565,000 | 0.32% | ||
| 45 | REINHART PARTNERS, LLC. | 120,981 | 1,463,000 | 0.30% | ||
| 46 | Polar Capital LLP | 111,673 | 1,350,000 | 0.27% | ||
| 47 | CADENCE CAPITAL MANAGEMENT LLC | 111,020 | 1,342,000 | 0.27% | ||
| 48 | STIFEL FINANCIAL CORP | 109,332 | 1,322,000 | 0.27% | ||
| 49 | SOROS FUND MANAGEMENT LLC | 107,308 | 1,297,000 | 0.26% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,208 | 1,260,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
