| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,182,799 | 157,195,000 | 34.47% | ||
| 2 | Foresite Capital Management II, LLC | 2,106,734 | 63,897,000 | 14.01% | ||
| 3 | FRANKLIN RESOURCES INC | 1,150,623 | 34,899,000 | 7.65% | ||
| 4 | ORBIMED ADVISORS LLC | 1,065,522 | 32,317,000 | 7.09% | ||
| 5 | JENNISON ASSOCIATES LLC | 749,899 | 22,254,000 | 4.88% | ||
| 6 | M&T BANK CORP | 567,143 | 17,202,000 | 3.77% | ||
| 7 | CLOUGH CAPITAL PARTNERS L P | 559,397 | 16,967,000 | 3.72% | ||
| 8 | Point72 Asset Management, L.P. | 507,072 | 15,379,000 | 3.37% | ||
| 9 | Rock Springs Capital Management LP | 350,000 | 10,616,000 | 2.33% | ||
| 10 | GILDER GAGNON HOWE & CO LLC | 322,862 | 9,792,000 | 2.15% | ||
| 11 | Clearbridge Investments, LLC | 223,084 | 6,766,000 | 1.48% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 209,300 | 6,348,000 | 1.39% | ||
| 13 | BlackRock Fund Advisors | 197,898 | 6,002,000 | 1.32% | ||
| 14 | LMCG INVESTMENTS, LLC | 166,908 | 5,062,000 | 1.11% | ||
| 15 | LORD, ABBETT & CO. LLC | 164,404 | 4,986,000 | 1.09% | ||
| 16 | BLACKROCK ADVISORS LLC | 152,979 | 4,640,000 | 1.02% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 84,010 | 2,548,000 | 0.56% | ||
| 18 | JPMORGAN CHASE & CO | 83,600 | 2,535,000 | 0.56% | ||
| 19 | BLAIR WILLIAM & CO/IL | 78,790 | 2,389,000 | 0.52% | ||
| 20 | STATE STREET CORP | 72,183 | 2,188,000 | 0.48% | ||
| 21 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 71,317 | 2,163,045 | 0.47% | ||
| 22 | FRED ALGER MANAGEMENT, LLC | 68,508 | 2,078,000 | 0.46% | ||
| 23 | PALISADE CAPITAL MANAGEMENT, LP | 64,191 | 1,947,000 | 0.43% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 64,160 | 1,946,000 | 0.43% | ||
| 25 | Redmile Group, LLC | 61,639 | 1,870,000 | 0.41% | ||
| 26 | Candriam S.C.A. | 60,673 | 1,840,000 | 0.40% | ||
| 27 | ALPS ADVISORS INC | 58,526 | 1,775,000 | 0.39% | ||
| 28 | PICTON MAHONEY ASSET MANAGEMENT | 43,600 | 1,322,000 | 0.29% | SH | |
| 29 | VANGUARD GROUP INC | 42,999 | 1,304,000 | 0.29% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 40,000 | 1,213,000 | 0.27% | ||
| 31 | DEUTSCHE BANK AG\ | 39,506 | 1,197,000 | 0.26% | ||
| 32 | AHL Partners LLP | 37,771 | 1,145,000 | 0.25% | ||
| 33 | BlackRock Investment Management, LLC | 34,936 | 1,060,000 | 0.23% | ||
| 34 | Visium Asset Management, LP | 34,264 | 1,039,000 | 0.23% | ||
| 35 | CITADEL ADVISORS LLC | 32,704 | 992,000 | 0.22% | ||
| 36 | Bank of New York Mellon Corp | 29,128 | 883,000 | 0.19% | ||
| 37 | ArrowMark Colorado Holdings LLC | 20,952 | 635,000 | 0.14% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,676 | 597,000 | 0.13% | ||
| 39 | NORTHERN TRUST CORP | 16,202 | 491,000 | 0.11% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,248 | 462,000 | 0.10% | ||
| 41 | MORGAN STANLEY | 14,582 | 442,000 | 0.10% | ||
| 42 | AMERIPRISE FINANCIAL INC | 14,161 | 430,000 | 0.09% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 13,500 | 409,000 | 0.09% | ||
| 44 | TEACHERS ADVISORS, LLC | 12,104 | 367,000 | 0.08% | ||
| 45 | State of New Jersey Common Pension Fund D | 11,700 | 355,000 | 0.08% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 11,158 | 338,000 | 0.07% | ||
| 47 | MANAGED ACCOUNT ADVISORS LLC | 10,209 | 310,000 | 0.07% | ||
| 48 | WELLS FARGO & COMPANY/MN | 9,702 | 295,000 | 0.06% | ||
| 49 | BlackRock Group LTD | 8,987 | 273,000 | 0.06% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,189 | 248,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
